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Cheruvallath Zaccharia S, Semple Joseph E, Wang Jing, Nutt Ruth F, Mylvaganam Shankari: Oxygen/nitrogen heterocycle inhibitors of tyrosine phosphatases. Cengent Therapeutics, Cheruvallath Zaccharia S, Semple Joseph E, Wang Jing, Nutt Ruth F, Mylvaganam Shankari, ROTHERY Brian M, February 16, 2006: WO/2006/017124 (2 worldwide citation)

Compounds, pharmaceutical compositions, and methods for treating, preventing, or ameliorating symptoms associated with diseases such as diabetes, cancer, neurodegenerative diseases, and obesity are provided. The compounds and compositions inhibit protein tyrosine phosphatase enzymes, e.g., PTP-1B.


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Cheruvallath Zacharia S, Loweth Colin J, Nutt Ruth F, Rideout Darryl, Semple J Edward, Wang Jing, Wu Feiyue, Mylvaganam Shankari, Zhu Hengyi, Sun Jianzhong: Derivatives of thiazole and thiadiazole inhibitors of tyrosine phosphatases. Cengent Therapeutics, Cheruvallath Zacharia S, Loweth Colin J, Nutt Ruth F, Rideout Darryl, Semple J Edward, Wang Jing, Wu Feiyue, Mylvaganam Shankari, Zhu Hengyi, Sun Jianzhong, RIEGER Dale L, March 16, 2006: WO/2006/028970 (1 worldwide citation)

Provided herein are compounds and compositions for modulation of tyrosine phosphatase activity. In one embodiment, compounds and compositions for inhibiting protein tyrosine phosphatase activity are provided. In another embodiment, provided herein are compounds and compositions that are useful in th ...


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Nutt Ruth F: Hexapeptides cycliques analogues de la somatostatine, Cyclic hexapeptide somatostatin analogs. Nutt Ruth F, Merck &Amp Co, GOUDREAU GAGE DUBUC, May 8, 1990: CA1268899

1741S/0700A17032 TITLE OF THE INVENTION CYCLIC HEXAPEPTIDE SOMATOSTATIN ANALOGS ABSTRACT OF THE DISCLOSURE Somatostatin analogs are prepared wherein acyclic hexapeptide contains a secondary amino acidwhich replaces seven of the ring amino acids ofsomatostatin. The cyclic hexapeptides are easier tosy ...


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Nicolaou Christodoulos A, Kelley Brian P, Nutt Ruth F, Bassett Susan I: Method and system for artificial intelligence directed lead discovery through multi-domain clustering. Bioreason, Nicolaou Christodoulos A, Kelley Brian P, Nutt Ruth F, Bassett Susan I, AARONSON Lawrence H, August 24, 2000: WO/2000/049539

A system for analyzing a vast amount of data representative of chemical structure and activity information and concisely providing conclusions about structure-to-activity relationships. A computer may adaptively learn new substructure descriptors based on its analysis of the input data. The computer ...


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Veber Daniel F, Lewis S Dale, Shafer Jules A, Feng Dong Mei, Nutt Ruth F, Brady Stephen F: Thrombin inhibitors. Merck & Co, Veber Daniel F, Lewis S Dale, Shafer Jules A, Feng Dong Mei, Nutt Ruth F, Brady Stephen F, MERCK Patent Dept 126 East Lincoln Avenue Rahway NJ 07065, November 10, 1994: WO/1994/025051

4-substituted cyclohexylamine derivatives which are thrombin catalytic site inhibitors and which are useful as anticoagulants. These compounds show selectivity for thrombin over other trypsin-like enzymes and have oral bioavailability. They have formula (a) or (b), for example (c).


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Webb Thomas R, Reiner John E, Tamura Susan Y, Ripka William C, Dagnino Raymond Jr, Nutt Ruth F: Methods of synthesis of peptidyl argininals. Corvas International, Webb Thomas R, Reiner John E, Tamura Susan Y, Ripka William C, Dagnino Raymond Jr, Nutt Ruth F, sBIGGS Suzanne L, December 28, 1995: WO/1995/035280

This invention provides solution-phase and solid-phase methods for the synthesis of peptidyl argininals and to novel reagents useful therein, which have formula (I), wherein R¿1? is selected from the group consisting of hydrogen, benzyloxycarbonyl, isonicotinyloxycarbonyl, 2-chlorobenzyloxycarbonyl, ...


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Semple Joseph Edward, Ardecky Robert J, Nutt Ruth F, Ripka William Charles, Rowley David C, Lim Wilby Marguerita S L, Brunck Terrence K: 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors. Corvas International, Semple Joseph Edward, Ardecky Robert J, Nutt Ruth F, Ripka William Charles, Rowley David C, Lim Wilby Marguerita S L, Brunck Terrence K, sBIGGS Suzanne L, December 28, 1995: WO/1995/035311

The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal t ...


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Levy Odile Esther, Tamura Susan Y, Nutt Ruth F, Ripka William C: Arginine mimic derivatives as enzyme inhibitors. Corvas International, Levy Odile Esther, Tamura Susan Y, Nutt Ruth F, Ripka William C, sBIGGS Suzanne L, December 28, 1995: WO/1995/035312

The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal t ...