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Lai Albert, Fanidi Abdallah, Booher Robert, Tse Christin, Xu Xie, Yu Guoying, Moler Edward, Rowe Michael: Cancer-related genes. Novartis Vaccines And Diagnostics, Sagres Discovery, Lai Albert, Fanidi Abdallah, Booher Robert, Tse Christin, Xu Xie, Yu Guoying, Moler Edward, Rowe Michael, October 19, 2006: WO/2006/110581 (83 worldwide citation)

This invention is in the field of cancer-associated genes. Specifically it relates to methods for detecting cancer or the likelihood of developing cancer based on the presence or absence of expression of certain genes or proteins encoded by those genes. The invention also provides methods and molecu ...


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Siew C Schleyer, Anne B Jefferson, Judith A Abraham, W Michael Kavanaugh: Use of NRG4, or inhibitors thereof, in the treatment of colon and pancreatic cancers. Novartis Vaccines and Diagnostics, Lisa E Alexander, Patricia Tsao, January 13, 2009: US07476506 (64 worldwide citation)

This invention relates to compositions and uses of NRG4, and to variants thereof and to polynucleotides encoding NRG4, for therapeutic and diagnostic purposes, particularly related to colon and pancreatic cancer. This invention also relates to therapeutic agents based on or derived from the polynucl ...


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Mario Contorni, Massimo Maffei: Vaccines comprising aluminium adjuvants and histidine. Novartis Vaccines and Diagnostics s r l, Banner & Witcoff, March 25, 2008: US07348006 (54 worldwide citation)

To improve the stability of vaccines comprising aluminum salt(s), the invention uses the amino acid histidine. This can improve pH stability and adjuvant adsorption and can be reduce antigen hydrolysis. Histidine is preferably presen during adsorption to the aluminium salt(s). The antigen in the vac ...


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Claire Fraser, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Marirosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulio Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, J Craig Venter: antigens and compositions. Novartis Vaccines and Diagnostics, Amy Hessler, Helen Lee, Robert Gorman, August 18, 2009: US07576176 (47 worldwide citation)

The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.


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Fanidi Abdallah, Booher Robert, Tse Christin: Cancer-related genes (prlr). Novartis Vaccines And Diagnostics, Sagres Discovery, Fanidi Abdallah, Booher Robert, Tse Christin, ROSENTHAL Julia, October 19, 2006: WO/2006/110585 (39 worldwide citation)

This invention is in the field of cancer-associated genes. Specifically it relates to methods for detecting cancer or the likelihood of developing cancer based on the presence or absence of expression of a PRLR gene or protein. The invention also provides methods and molecules for upregulating or do ...


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Valiante Nicholas, Xu Feng, Lin Xiaodong, Chu Daniel, Wang Xiaojing Michael: Imidazoquinoline compounds. Novartis Vaccines And Diagnostics, Valiante Nicholas, Xu Feng, Lin Xiaodong, Chu Daniel, Wang Xiaojing Michael, SILVER Joel, March 23, 2006: WO/2006/031878 (38 worldwide citation)

The invention provides novel compositions comprising imidazoquinoline compounds. Also provided are methods of administering the compositions in an effective amount to enhance the immune response of a subject. Further provided are novel compositions and methods of administering the compositions in co ...


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Pablo D Garcia, Stephen F Hardy, Jaime Escobedo, Lewis T Williams: Endogenous retroviruses up-regulated in prostate cancer. Novartis Vaccines and Diagnostics, Mei Hong, Benjamin Spehlmann, August 17, 2010: US07776523 (37 worldwide citation)

Human endogenous retroviruses of the HML-2 family show up-regulated expression in prostate tumors. This finding can be used in prostate cancer screening, diagnosis and therapy.


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Yu Guoying, Moler Edward, Rowe Michael, Tse Christin, Xu Xie: Cacna1e in cancer diagnosis, detection and treatment. Novartis Vaccines And Diagnostics, Sagres Discovery, Yu Guoying, Moler Edward, Rowe Michael, Tse Christin, Xu Xie, October 19, 2006: WO/2006/110599 (37 worldwide citation)

This invention is in the field of cancer-related genes. Specifically it relates to methods for detecting cancer or the likelihood of developing cancer based on the presence or absence of the CACNA1E gene or proteins encoded by this gene. The invention also provides methods and molecules for upregula ...


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Derek O Hagan, Manmohan Singh: Compositions for inducing immune responses. Novartis Vaccines and Diagnostics, Helen Lee, David Bonham, Robert Gorman, June 8, 2010: US07731967 (34 worldwide citation)

The invention provides, inter alia, immunogenic compositions comprising a first antigen, at least two adjuvants, wherein a first adjuvant comprises a polymer derived from poly(lactides) and/or poly(lactide-co-glycolides), and wherein a second adjuvant comprises an imidazoquinoline, wherein said firs ...