1
Brent R Constantz: In situ calcium phosphate minerals--method and composition. Norian Corporation, Bertram I Rowland, November 14, 1989: US04880610 (185 worldwide citation)

Calcium phosphate minerals are formed by using highly concentrated phosphoric acid in conjunction with a calcium source, normaly as carbonate or a combination of carbonate and hydroxide, optimally in conjunction with calcium phosphate crystals and additional base to neutralize the phosphoric acid. P ...


2
Brent R Constantz, Bryan Barr, Kevin McVicker: Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite. Norian Corporation, Bertram I Rowland, October 1, 1991: US05053212 (168 worldwide citation)

Novel compositions are provided for the production of hydroxyapatite, where a dry mixture is provided which combines a calcium source and an acidic phosphate source, particularly monocalcium phosphate monohydrate or orthophosphoric acid crystals. These two are combined, optionally with other ingredi ...


3
Brent R Constantz: In situ calcium phosphate minerals method. Norian Corporation, Bertram I Rowland, September 10, 1991: US05047031 (130 worldwide citation)

Calcium phosphate minerals are formed by using phosphoric acid substantially free of uncombined water in conjunction with a calcium source, normally as any combination of carbonate, phosphate and hydroxide, and, as required, any additional base to neutralize the phosphoric acid. Protein may be optio ...


4
Brent R Constanz, Mark T Fulmer, Bryan M Barr: Situ prepared calcium phosphate composition and method. Norian Corporation, Bertram I Rowland, Bret E Field, August 9, 1994: US05336264 (130 worldwide citation)

Setting times of calcium phosphate cement compositions are enhanced by the addition of phosphate or carbonate lubricant compositions. Methods for preparing the cement compositions are provided.


5
Brent R Constantz: Methods for in situ prepared calcium phosphate minerals. Norian Corporation, Bertram I Rowland, July 14, 1992: US05129905 (120 worldwide citation)

Calcium phosphate minerals are formed by using phosphoric acid source substantially free of uncombined water in conjunction with a calcium source, normally as any combination of carbonate, phosphate and hydroxide, and, as required, any additional base to neutralize the phosphoric acid. Protein may b ...


6
Ira C Ison, Mark T Fulmer, Bryan M Barr, Brent R Constantz: Storage stable calcium phosphate cements. Norian Corporation, Bertram I Rowland, Bret E Field, March 5, 1996: US05496399 (106 worldwide citation)

Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component ...


7
Brent R Constantz: Methods of repairing bone. Norian Corporation, Bret Field, Bozicevic Field & Francis, December 21, 1999: US06005162 (99 worldwide citation)

Methods are provided for repairing bone. In the subject methods, a flowable composition capable of setting under physiological conditions into an physiologically acceptable calcium phosphate mineral is administered to a bone repair site. Following administration, the composition is allowed to harden ...


8
Brent R Constantz, Ben Clawson: Methods and devices for the preparation, storage and administration of calcium phosphate cements. Norian Corporation, Bret Field, Bozicevic Field & Francis, November 21, 2000: US06149655 (99 worldwide citation)

A system is provided for the storage, preparation and administration of calcium phosphate cements. The subject invention provides a storage means for storing a two component calcium phosphate cement having a liquid component and a dry component. Also provided is a preparation means for combining the ...


9
Ira C Ison, Mark T Fulmer, Bryan M Barr, Brent R Constantz: Method for repairing bone. Norian Corporation, Bret E Field, Townsend and Townsend and Crew, December 16, 1997: US05697981 (98 worldwide citation)

Methods and compositions for use in bone repair are provided. The subject methods employ a two component calcium phosphate cement having a dry component and a lubricant, wherein the dry component of the cement comprises basic calcium phosphate particles at least partially coated with a partially neu ...


10
Brent R Constantz, Bryan M Barr: Calcium phosphate cements comprising amorophous calcium phosphate. Norian Corporation, Bret E Field, Bozicevic & Reed, July 21, 1998: US05782971 (98 worldwide citation)

Calcium phosphate cements are provided. The subject cements comprise amorphous calcium phosphate, at least one additional calcium source, usually an additional calcium phosphate, and a liquid component, such as a physiologically acceptable lubricant. Upon combination of the cement components, a flow ...