1
Kimihiro Shimizu, Tsuguji Nakahara, Taketoshi Kinoshita, Jun Takatsuka, Michiko Igarashi: Plasminogen activator derivatives. Nippon Chemiphar Company, Oblon Fisher Spivak McClelland & Maier, February 3, 1987: US04640835 (346 worldwide citation)

Derivatives of a nonimmunogenic plasminogen activator which comprises at least one polyalkylene glycol group chemically bonded with at least one coupling agent to amino acid side chains of said plasminogen activator, wherein said polyalkylene glycol has a molecular weight of about 200-20,000 and is ...


2
Yasuo Fujimoto, Shigeru Yamabe: Propionic acid derivatives. Nippon Chemiphar Company, Oblon Fisher Spivak McClelland & Maier, May 27, 1980: US04205170 (7 worldwide citation)

Propionic acid derivatives having the formula ##STR1## wherein X represents an oxygen or two hydrogen atoms, Y represents CH or N, A represents an oxygen or sulfur atom, and R represents hydroxy, amino, or a lower alkoxy group having 1 to 5 carbon atoms are antiinflammatory agents.


3
Yasuo Fujimoto, Terumi Tamada: 5-Phenethyl-2-oxazolidone derivatives and a process for producing the same. Nippon Chemiphar Company, Oblon Fisher Spivak McClelland & Maier, November 25, 1980: US04236012 (5 worldwide citation)

5-Phenethyl oxazolidone compounds having the formula: ##STR1## wherein R represents a hydrogen or halogen atom or a lower alkoxy group have muscular relaxing, analgetic and antiinflammatory activities.


4
Yasuo Fujimoto, Yasuo Kishi: Penicillin derivatives. Nippon Chemiphar Company, Oblon Fisher Spivak McClelland & Maier, August 26, 1980: US04219477 (3 worldwide citation)

Penicillin and cephalosporin derivatives and non-toxic salts thereof represented by the formula (1), ##STR1## wherein Ar represents a phenyl or heterocyclic group which may be substituted by a halogen atom, or a hydroxy or lower alkoxy group, R represents a hydrogen atom or a hydroxy group, X repres ...


5
Shigeru Yamabe, Yasuo Fujimoto, Shoji Ryu, Yoshio Suzuki, Yoshihiro Tanaka, Toru Yamanaka, Kiyosato Nyu: Benzo[b,f]thiepan derivitives. Nippon Chemiphar Company, Oblon Fisher Spivak McClelland & Maier, October 14, 1980: US04228284 (1 worldwide citation)

9-(.beta.-hydroxyethyl) piperazinyl-carbonyl-2-trifluoromethyl-10, 11-dihydrodibenzo[b,f]thiepin is prepared and disclosed as having antiinflamatory action.