1
Nicolau Yves Claude, Greferath Ruth, Hickman David: Methods and compositions comprising supramolecular constructs. Ac Immune, Nicolau Yves Claude, Greferath Ruth, Hickman David, PRATT John S, September 9, 2005: WO/2005/081872 (23 worldwide citation)

The present invention comprises novel compositions and methods for eliciting high immune responses, of great specificity yielding conformationally sensitive antibodies. These antibodies recognize specific epitopes on a wide variety of antigens including but not limited to, amyloid protein, prion pro ...


2
Basil T Hone Receiver Of Hapgo, Atkin Andrew, Lazarte Jaime E, Nicolau Yves Claude, Tosi Pierre Francois, Black Christopher Douglas Vali: Diagnostic device and method. Basil T Hone Receiver Of Hapgo, Atkin Andrew, Lazarte Jaime E, Nicolau Yves Claude, Tosi Pierre Francois, Black Christopher Douglas Vali, January 10, 1996: EP0690989-A1

The present invention encompasses membranous baculovirus-derived vesicle compositions having exposed on their external surfaces a ligator capable of selectively binding a ligand to be detected. The compositions also have exposed on their outer surfaces a signal reagent capable of reacting with anoth ...


3
Nicolau Yves Claude, Lehn Jean Marie: Agents for the enhanced oxygen delivery in mammals. Gmp Companies, Nicolau Yves Claude, Lehn Jean Marie, GORDON Dana, March 1, 2001: WO/2001/013933

The present invention comprises compounds, compositions thereof, and methods capable of delivering a broad range of anionic molecules to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of ...


4
Nicolau Yves Claude, Eliseev Alexey, Lehn Jean Marie: Methods and compositions comprising non-peptide small molecules that solubilize beta amyloid peptide fiber. Ac Immune, Nicolau Yves Claude, Eliseev Alexey, Lehn Jean Marie, PRATT John S, September 9, 2005: WO/2005/081897

The present invention comprises novel compositions and methods for the treatment of neurological diseases associated with beta amyloid peptide. In particular, the present invention is directed to Aß fiber solubilization, for the treatment of amyloid-associated diseases such as Alzheimer's disease, a ...


5
Nicolau Yves Claude: Methods and compositions for diseases associated with amyloidosis. Aventis Pharma, Universite Louis Pasteur, Nicolau Yves Claude, sMERCHANT Mary Anthony, March 14, 2002: WO/2002/021141

The present invention generally relates to the detection, treatment or prevention of disease states. Specifically, the present invention relates to the detection, treatment or prevention of amyloidosis or amyloid-associated diseases. The present invention further comprises methods and compositions c ...


6
Nicolau Yves Claude, Greferath Ruth: Monoclonal antibodies specific for beta-amyloid.. Diagenics International Corporation, Nicolau Yves Claude, Greferath Ruth, MALONE Janina A, May 15, 2003: WO/2003/039467

This invention provides methods and compositions for the detection, diagnosis and treatment of amyloid-associated diseases, in particular, diseases comprising deposition of amyloid assemblies, fibrils, filaments, tangles, or plaques. A preferred composition comprises monoclonal antibodies that speci ...


7
Nicolau Yves Claude, Tosi Pierre François: Method of reducing multidrug resistance in cells and tissues. Nicolau Yves Claude, Tosi Pierre François, STERNAGEL Hans Günther, May 11, 1994: WO/1994/010198

Methods and vaccine compositions for reducing or inhibiting multidrug resistance in cancer cells and tissues, and more particularly antigenic P-glycoprotein-containing compositions that, when administered to a human or animal with a multidrug resistance cancer or tumor, elicit the production of anti ...


8
Basil T Hone Receiver Of Hapgood Cv, Atkin Andrew, Lazarte Jaime E, Nicolau Yves Claude, Tosi Pierre François, Black Christopher: Diagnostic device and method. Basil T Hone Receiver Of Hapgood Cv, Atkin Andrew, Lazarte Jaime E, Nicolau Yves Claude, Tosi Pierre François, Black Christopher, JOHNSON James Dean, September 29, 1994: WO/1994/022015

The present invention encompasses membranous baculovirus-derived vesicle compositions having exposed on their external surfaces a ligator capable of selectively binding a ligand to be detected. The compositions also have exposed on their outer surfaces a signal reagent capable of reacting with anoth ...


9
Nicolau Yves Claude, Bruggemann Ulrich, Mouneimne Yousef, Roux Eric Conrad: Method and apparatus for encapsulation of biologically-active substances in cells. Cbr Laboratories, Nicolau Yves Claude, Bruggemann Ulrich, Mouneimne Yousef, Roux Eric Conrad, TAUTVYDAS Daiva K, September 29, 1994: WO/1994/021117

The present invention relates to a method and apparatus for the encapsulation of biologically-active substances in red blood cells, characterized by an optionally automated, continuous-flow self-contained electroporation system (10), as shown in the figure which allows withdrawal of blood from a pat ...


10
LEHN Jean Marie, NICOLAU Yves Claude, JOGIREDDY Rajamalleswaramma, BROCKMAN Adam H, HEY John, YU Yongxin: DÉRIVÉS DE SACCHARIDES POLYPHOSPHATÉS ET PYROPHOSPHATÉS, POLYPHOSPHATE AND PYROPHOSPHATE DERIVATIVE OF SACCHARIDES. NORMOXYS, UNIVERSlTE DE STRASBOURG, LEHN Jean Marie, NICOLAU Yves Claude, JOGIREDDY Rajamalleswaramma, BROCKMAN Adam H, HEY John, YU Yongxin, ALTIERI Stephen L, April 5, 2012: WO/2012/045009

The present invention provides, among other things, phosphorylated and pyrophosphate derivatives of mono-, di- and oligosaccharides, as well as structural derivatives of these compounds. These compounds have a variety of uses including for pharmaceutical applications. Also provided are methods of us ...