1
Dasari Venkata Krishna Rao, Adibhatla Kali, Satya Bhujanga Rao, Venkaiah, Chowdary Nannapaneni: An efficient and novel purification method of recombinant hg-csf. Natco Pharma, Dasari Venkata Krishna Rao, Adibhatla Kali, Satya Bhujanga Rao, Venkaiah, Chowdary Nannapaneni, August 14, 2008: WO/2008/096370 (35 worldwide citation)

The present invention relates to Recombinant human Granulocyte Colony Stimulating Factor (G-CSF) and describes a novel purification process for a simple, economically feasible, largely scalable production of pharmaceutically acceptable grade product with high recovery of rhG-CSF expressed from bacte ...


2
Amala Kompella, Srinivasa, Rao Thungathurthi, Adibhatla Kali, Satya Bhujanga Rao, Rachakonda Sreenivas, Venkaiah, Chowdary Nannapaneni, Podili Khadgapathi: Novel polymorphic form of imatinib mesylate and a process for its preparation. Natco Pharma, Amala Kompella, Srinivasa, Rao Thungathurthi, Adibhatla Kali, Satya Bhujanga Rao, Rachakonda Sreenivas, Venkaiah, Chowdary Nannapaneni, Podili Khadgapathi, August 25, 2005: WO/2005/077933 (14 worldwide citation)

This invention discloses a novel stable crystal form of imatinib mesylate, designated by us as &agr;2 Form, which is stable at room temperature and even at higher temperatures upto 120 °C and accelerated stress conditions and, freely soluble in water. This invention also discloses a pharmaceutical c ...


3
Kompella Amala Kishan, Adibhatla Kali, Satya Bhujanga Rao, Podili Khadgapathi, Venkaiah, Chowdary Nannapaneni: Polymorphic forms of imatinib mesylate. Natco Pharma, Kompella Amala Kishan, Adibhatla Kali, Satya Bhujanga Rao, Podili Khadgapathi, Venkaiah, Chowdary Nannapaneni, May 26, 2006: WO/2006/054314 (14 worldwide citation)

The present invention relates to novel crystalline polymorphic Form I & Form II of imatinib mesylate and methods for their preparation. The Form I is prepared by slurrying imatinib mesylate &agr;2 or &bgr; polymorphic Form in chloroform and water with heating and distilling off water followed by fil ...


4
Durga, Maheswari Parvataneni, Appalaswamy, Naidu Rongala, Podile Khadgapathi, Venkaiah, Chowdary Nannapaneni: Controlled release mucoadhesive matrix formulation containing tolterodine and a process for its preparation. Natco Pharma, Durga, Maheswari Parvataneni, Appalaswamy, Naidu Rongala, Podile Khadgapathi, Venkaiah, Chowdary Nannapaneni, November 10, 2005: WO/2005/105036 (14 worldwide citation)

Controlled release oral pharmaceutical mucoadhesive matrix formulation containing a therapeutically effective amount of tolterodine or its pharmaceutically acceptable salts, prodrugs and metabolites thereof dispersed in a rate controlling polymeric matrix comprising (1) a pH independent gelling poly ...


5
Kompella Amala, Bhujanga, Rao Adibhatla Kali Sathya, Venkaiah, Chowdary Nannapaneni, Srinivas Rachakonda: Process for the preparation of the anti-cancer drug imatinib and its analogues. Natco Pharma, Kompella Amala, Bhujanga, Rao Adibhatla Kali Sathya, Venkaiah, Chowdary Nannapaneni, Srinivas Rachakonda, December 16, 2004: WO/2004/108699 (11 worldwide citation)

The present invention discloses a process of the manufacture of imatinib of formula (Ia) and its new analogues I (b-d) through the intermediate of formula (II). The mesylate (methane sulfonate ) salt of imatinib base (Ia[(4-(4-methylpiperazin-1-ylmethyl)-N4 [methyl-3-(4-pyridin-3-yl)pyrimidn-2-yl am ...


6
Pulla Reddy Muddasani, Venkaiah Chowdary Nannapaneni: Process for the preparation of sorafenib. Natco Pharma, Pulla Reddy Muddasani, Venkaiah Chowdary Nannapaneni, April 30, 2009: WO/2009/054004 (10 worldwide citation)

A novel and improved process for the preparation of sorafenib (4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide) of formula I involving a novel intermediate of formula II as key intermediate is disclosed. Sorafenib tosylate, available in the market as Nexavar is a mul ...


7
KONAKANCHI DURGA PRASAD: Anhydrous lenalidomide form-i. NATCO PHARMA, September 15, 2011: WO/2011/111053 (9 worldwide citation)

Anhydrous polymorphic form-I of anti cancer drug, Lenalidomide whose chemical name is 3-(4-amino-1-oxo-1, 3-dihydro-isoindole-2-yl)-piperidine-2, 6-dione, is disclosed. Alternate methods for making anhydrous polymorphic form-I of Lenalidomide are also disclosed.


8
Pulla, Reddy Muddasani, Usha, Rani Vattikuti, Venkaiah, Chowdary Nannapaneni: An improved process for the preparation of zoledronic acid. Natco Pharma, Pulla, Reddy Muddasani, Usha, Rani Vattikuti, Venkaiah, Chowdary Nannapaneni, July 14, 2005: WO/2005/063717 (8 worldwide citation)

The invention disclosed in this application relates to an improved process for the preparation of zoledronic acid of formula (I) given below which comprises heating at a temperature in the range of 50-80 °C a solution of imidazol-1-ylacetic acid hydrochloride with ortho-phosphoric acid in a solvent ...


9
Venkateswara Rao Pavuluri, Khadgapathi Podili: An rapid acting freeze dired oral pharmaceutical composition for treating migraine. Natco Pharma, October 9, 2002: EP1246668-A1 (7 worldwide citation)

The present invention relates to a novel freeze - dried pharmaceutical composition useful for the treatment of migraine and associated symptoms at a reduced total dose of active substance than required for oral administration in the form of a tablet comtaining a porous matrix net work of a water sol ...


10
Kompella Amala Kishan, Adibhatla Kali, Satya Bhujanga Rao, Rachakonda Sreenivas, Podili Khadgapathi, Venkaiah, Chowdary Nannapaneni: Novel phenylaminopyrimidine derivatives as inhibitors of bcr-abl kinase. Natco Pharma, Kompella Amala Kishan, Adibhatla Kali, Satya Bhujanga Rao, Rachakonda Sreenivas, Podili Khadgapathi, Venkaiah, Chowdary Nannapaneni, March 16, 2006: WO/2006/027795 (7 worldwide citation)

The present invention relates to novel intermediates useful for the preparation of novel phenylaminopyrimidine derivatives, novel phenylaminopyrimidine derivatives. Pharmaceutical composition containing the novel phenylaminopyrimidine derivatives and processes for their preparation. The invention pa ...



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