1
Dasari Venkata Krishna Rao, Adibhatla Kali, Satya Bhujanga Rao, Venkaiah, Chowdary Nannapaneni: An efficient and novel purification method of recombinant hg-csf. Natco Pharma, Dasari Venkata Krishna Rao, Adibhatla Kali, Satya Bhujanga Rao, Venkaiah, Chowdary Nannapaneni, August 14, 2008: WO/2008/096370 (35 worldwide citation)

The present invention relates to Recombinant human Granulocyte Colony Stimulating Factor (G-CSF) and describes a novel purification process for a simple, economically feasible, largely scalable production of pharmaceutically acceptable grade product with high recovery of rhG-CSF expressed from bacte ...


2
Durga, Maheswari Parvataneni, Appalaswamy, Naidu Rongala, Podile Khadgapathi, Venkaiah, Chowdary Nannapaneni: Controlled release mucoadhesive matrix formulation containing tolterodine and a process for its preparation. Natco Pharma, Durga, Maheswari Parvataneni, Appalaswamy, Naidu Rongala, Podile Khadgapathi, Venkaiah, Chowdary Nannapaneni, November 10, 2005: WO/2005/105036 (17 worldwide citation)

Controlled release oral pharmaceutical mucoadhesive matrix formulation containing a therapeutically effective amount of tolterodine or its pharmaceutically acceptable salts, prodrugs and metabolites thereof dispersed in a rate controlling polymeric matrix comprising (1) a pH independent gelling poly ...


3
Amala Kompella, Srinivasa, Rao Thungathurthi, Adibhatla Kali, Satya Bhujanga Rao, Rachakonda Sreenivas, Venkaiah, Chowdary Nannapaneni, Podili Khadgapathi: Novel polymorphic form of imatinib mesylate and a process for its preparation. Natco Pharma, Amala Kompella, Srinivasa, Rao Thungathurthi, Adibhatla Kali, Satya Bhujanga Rao, Rachakonda Sreenivas, Venkaiah, Chowdary Nannapaneni, Podili Khadgapathi, August 25, 2005: WO/2005/077933 (14 worldwide citation)

This invention discloses a novel stable crystal form of imatinib mesylate, designated by us as &agr;2 Form, which is stable at room temperature and even at higher temperatures upto 120 °C and accelerated stress conditions and, freely soluble in water. This invention also discloses a pharmaceutical c ...


4
Kompella Amala Kishan, Adibhatla Kali, Satya Bhujanga Rao, Podili Khadgapathi, Venkaiah, Chowdary Nannapaneni: Polymorphic forms of imatinib mesylate. Natco Pharma, Kompella Amala Kishan, Adibhatla Kali, Satya Bhujanga Rao, Podili Khadgapathi, Venkaiah, Chowdary Nannapaneni, May 26, 2006: WO/2006/054314 (14 worldwide citation)

The present invention relates to novel crystalline polymorphic Form I & Form II of imatinib mesylate and methods for their preparation. The Form I is prepared by slurrying imatinib mesylate &agr;2 or &bgr; polymorphic Form in chloroform and water with heating and distilling off water followed by fil ...


5
Kompella Amala, Bhujanga, Rao Adibhatla Kali Sathya, Venkaiah, Chowdary Nannapaneni, Srinivas Rachakonda: Process for the preparation of the anti-cancer drug imatinib and its analogues. Natco Pharma, Kompella Amala, Bhujanga, Rao Adibhatla Kali Sathya, Venkaiah, Chowdary Nannapaneni, Srinivas Rachakonda, December 16, 2004: WO/2004/108699 (11 worldwide citation)

The present invention discloses a process of the manufacture of imatinib of formula (Ia) and its new analogues I (b-d) through the intermediate of formula (II). The mesylate (methane sulfonate ) salt of imatinib base (Ia[(4-(4-methylpiperazin-1-ylmethyl)-N4 [methyl-3-(4-pyridin-3-yl)pyrimidn-2-yl am ...


6
Pulla Reddy Muddasani, Venkaiah Chowdary Nannapaneni: Process for the preparation of sorafenib. Natco Pharma, Pulla Reddy Muddasani, Venkaiah Chowdary Nannapaneni, April 30, 2009: WO/2009/054004 (10 worldwide citation)

A novel and improved process for the preparation of sorafenib (4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide) of formula I involving a novel intermediate of formula II as key intermediate is disclosed. Sorafenib tosylate, available in the market as Nexavar is a mul ...


7
KONAKANCHI DURGA PRASAD: Anhydrous lenalidomide form-i. NATCO PHARMA, September 15, 2011: WO/2011/111053 (9 worldwide citation)

Anhydrous polymorphic form-I of anti cancer drug, Lenalidomide whose chemical name is 3-(4-amino-1-oxo-1, 3-dihydro-isoindole-2-yl)-piperidine-2, 6-dione, is disclosed. Alternate methods for making anhydrous polymorphic form-I of Lenalidomide are also disclosed.


8
Pulla, Reddy Muddasani, Usha, Rani Vattikuti, Venkaiah, Chowdary Nannapaneni: An improved process for the preparation of zoledronic acid. Natco Pharma, Pulla, Reddy Muddasani, Usha, Rani Vattikuti, Venkaiah, Chowdary Nannapaneni, July 14, 2005: WO/2005/063717 (9 worldwide citation)

The invention disclosed in this application relates to an improved process for the preparation of zoledronic acid of formula (I) given below which comprises heating at a temperature in the range of 50-80 °C a solution of imidazol-1-ylacetic acid hydrochloride with ortho-phosphoric acid in a solvent ...


9
Ramanadham Jyothi Prasad, Bollepalli Nageshwar Rao, Nannapaneni Venkaiah Chowdary: Process for the prepartion of erlotinib. Natco Pharma, Merchant & Gould P C, June 14, 2011: US07960545 (7 worldwide citation)

The present invention discloses an improved and novel process for the preparation of erlotinib (N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine) of formula (1), which comprises: (i) demethylation of commercially available 6,7-dimethoxy-4(3H)-quinazolinone of formula (8); acetylation u ...


10
Venkateswara Rao Pavuluri, Khadgapathi Podili: An rapid acting freeze dired oral pharmaceutical composition for treating migraine. Natco Pharma, October 9, 2002: EP1246668-A1 (7 worldwide citation)

The present invention relates to a novel freeze - dried pharmaceutical composition useful for the treatment of migraine and associated symptoms at a reduced total dose of active substance than required for oral administration in the form of a tablet comtaining a porous matrix net work of a water sol ...