1
Modlin Douglas N, Chazan David: Microfluidic system with integrated permeable membrane. Cytodiscovery, Modlin Douglas N, Chazan David, ABNEY James R, July 15, 2004: WO/2004/059299 (26 worldwide citation)

A microfluidic system for performing chemical reactions or biochemical, biological, or chemical assays utilizing a microfabricated device or 'chip' is provided. The device comprises an integrated membrane fabricated from a chemically inert material whose permeability for gases, liquids, cells, and s ...


2
Stumbo David P, Modlin Douglas N: Light detection device. Ljl Biosystems, Stumbo David P, Modlin Douglas N, ABNEY James R, January 18, 2001: WO/2001/004608

Apparatus and methods for optical detection with improved read speed and/or signal-to-noise ratio. These apparatus and methods may involve among others moving a sample substrate (108) while simultaneously detecting light transmitted from one or more sample sites (110) on the substrate (108) by seque ...


3
Winkler James L, Fodor Stephan P A, Buchko Christopher J, Ross Debra A, Aldwin Lois, Modlin Douglas N: Combinatorial strategies for polymer synthesis. Affymax Technology, Winkler James L, Fodor Stephan P A, Buchko Christopher J, Ross Debra A, Aldwin Lois, Modlin Douglas N, WEAVER Jeffrey K, May 27, 1993: WO/1993/009668

A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rota ...


4
Modlin Douglas N, French Todd E, Petersen Jon F, Owicki John C: Methods and apparatus for detecting polynucleotide hybridization. Ljl Biosystems, Modlin Douglas N, French Todd E, Petersen Jon F, Owicki John C, ABNEY James R, July 20, 2000: WO/2000/042209

Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) contacting a sample polynucleotide with a reference polynucleotide at an assay site, where at least one of the polynucleotides is capable of emitting luminescence, (2) illuminat ...


5
French Todd E, Stumbo David P, Modlin Douglas N: Frequency-domain light detection device. Ljl Biosystems, French Todd E, Stumbo David P, Modlin Douglas N, ABNEY James R, August 31, 2000: WO/2000/050877

Apparatus and methods for determining temporal properties of photoluminescent samples using frequency-domain photoluminescence measurements, where the measurements may include photon counting and/or the separation of measured luminescence into potentially overlapping time bins. The apparatus may inc ...


6
Marquiss Samuel A, Cesar Christopher G, Petersen Jon F, Stumbo David P, El Hage Amer, Edwards Glenn R, Modlin Douglas N, Leytes Lev J, Burd Samuel: Integrated sample-processing system. Ljl Biosystems, Marquiss Samuel A, Cesar Christopher G, Petersen Jon F, Stumbo David P, El Hage Amer, Edwards Glenn R, Modlin Douglas N, Leytes Lev J, Burd Samuel, ABNEY James R, November 9, 2000: WO/2000/066269

The invention provides an integrated sample-processing system (500) and components thereof for preparing and/or analyzing samples. The components may include a transport module (504), a fluidics module (506), and an analysis module (508), among others.


7
French Todd E, Modlin Douglas N, Owicki John C, Richey James S, Leytes Lev J, Razvi Enal S, Zhang Klompus Yan, Panfili Peter R: Methods and apparatus for detecting nucleic acid polymorphisms. Ljl Biosystems, French Todd E, Modlin Douglas N, Owicki John C, Richey James S, Leytes Lev J, Razvi Enal S, Zhang Klompus Yan, Panfili Peter R, ABNEY James R, September 21, 2000: WO/2000/055372

Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) allele-specific hybridization, using luminescence detection, (2) allele-specific oligonucleotide ligation, using dye-labeled oligonucleotide ligation with luminescence resonance ...


8
Modlin Douglas N, Stumbo David P, Stellmacher Rick V: Broad range light detection system. Ljl Biosystems, Modlin Douglas N, Stumbo David P, Stellmacher Rick V, ABNEY James R, August 26, 1999: WO/1999/042817

A broad-range light-detection system. In some embodiments, the system includes apparatus and methods for detecting light with high accuracy over a broad range of intensities. In other embodiments, the system includes apparatus and methods for automatically scaling the detection range to improve dete ...


9
Owicki John C, Modlin Douglas N, French Todd E: Apparatus and methods for identifying quenching effects in luminescence assays. Ljl Biosystems, Owicki John C, Modlin Douglas N, French Todd E, ABNEY James R, February 10, 2000: WO/2000/006989

Apparatus and methods for identifying and correcting for quenching in luminescence assays using luminescence lifetimes and/or luminescence intensities. One aspect of the invention involves identifying quenching using combinations of luminescence lifetimes and/or intensities. Another aspect of the in ...


10
Modlin Douglas N, French Todd E, Owicki John C: Apparatus and methods for time-resolved spectroscopic measurements. Ljl Biosystems, Modlin Douglas N, French Todd E, Owicki John C, ABNEY James R, February 10, 2000: WO/2000/006990

Apparatus and method for measuring light transmitted from a sample. The apparatus may include a stage (123), a light source (103), and a detector (145). The stage (123) may be configured to hold a microplate (124) having a plurality of sample wells (126). The apparatus may be configured to take freq ...