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SCHRUM Jason P, AFEYAN Noubar B, SIECZKIEWICZ Gregory J, BANCEL Stephane, DE FOUGEROLLES Antonin, ELBASHIR Sayda M: ADMINISTRATION ET FORMULATION DACIDES NUCLÉIQUES GÉNÉTIQUEMENT MODIFIÉS, DELIVERY AND FORMULATION OF ENGINEERED NUCLEIC ACIDS. MODERNA THERAPEUTICS, SCHRUM Jason P, AFEYAN Noubar B, SIECZKIEWICZ Gregory J, BANCEL Stephane, DE FOUGEROLLES Antonin, ELBASHIR Sayda M, WARD Donna T, October 4, 2012: WO/2012/135805 (55 worldwide citation)

Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.


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BANCEL Stephane: [fr] PROCÉDÉS DE RÉPONSE À UNE MENACE BIOLOGIQUE, [en] METHODS OF RESPONDING TO A BIOTHREAT. MODERNA THERAPEUTICS, WARD Donna T, September 6, 2013: WO/2013/130161 (45 worldwide citation)

[en] The present disclosure provides for devices, in particular mobile devices, which may be used in the synthesis of modified nucleic acid molecules, in particular modified mRNA molecules. The devices for making the modified nucleosides, modified nucleotides and modified nucleic acids (e.g., mRNA) ...


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Jason P Schrum, Noubar B Afeyan, Gregory J Sieczkiewicz, Stephane Bancel, Antonin de Fougerolles, Sayda M Elbashir: Engineered nucleic acids encoding a modified erythropoietin and their expression. Moderna Therapeutics, DT Ward P C, Donna T Ward, Jennifer F Bryan, April 29, 2014: US08710200 (40 worldwide citation)

Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.


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BANCEL Stephane, CHAKRABORTY Tirtha, DE FOUGEROLLES Antonin, ELBASHIR Sayda M, JOHN Matthias, ROY Atanu, WHORISKEY Susan, WOOD Kristy M, HATALA Paul, SCHRUM Jason P, EJEBE Kenechi, ELLSWORTH Jeff Lynn, GUILD Justin: [fr] POLYNUCLÉOTIDES MODIFIÉS POUR LA PRODUCTION DE PROTÉINES MEMBRANAIRES, [en] MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF MEMBRANE PROTEINS. MODERNA THERAPEUTICS, WARD Donna T, October 10, 2013: WO/2013/151663 (40 worldwide citation)

[en] The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides. More specifically, the disclosure provides compositions, methods, processes, kits and devices for the design, preparation, manufacture and/or formulation of modified mRNA ...


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Antonin de Fougerolles, Kristy M Wood, Sayda M Elbashir, Jason P Schrum: Modified polynucleotides for the production of G-CSF. Moderna Therapeutics, DT Ward P C, Donna T Ward, Jennifer F Bryan, March 25, 2014: US08680069 (38 worldwide citation)

The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified n ...


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Antonin de Fougerolles, Kristy M Wood, Sayda M Elbashir, Jason P Schrum: Method for producing a protein of interest in a primate. Moderna Therapeutics, DT Ward P C, Jennifer F Bryan, March 4, 2014: US08664194 (26 worldwide citation)

The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified n ...


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Antonin de Fougerolles, Kristy M Wood, Sayda M Elbashir, Jason P Schrum: DLIN-KC2-DMA lipid nanoparticle delivery of modified polynucleotides. Moderna Therapeutics, DT Ward P C, Jennifer F Bryan, June 17, 2014: US08754062 (24 worldwide citation)

The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified n ...


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