1
Anton Hubert Clemens, Robert Weston Myers: Blood glucose control apparatus. Miles Laboratories, Louis E Davidson, October 25, 1977: US04055175 (561 worldwide citation)

Apparatus is described for controlling blood glucose concentration in a subject by selected infusion of insulin and/or glucose, depending upon the general blood glucose concentration. This apparatus comprises in combination sensor means for measuring the blood glucose concentration and for providing ...


2
Gautam Mitra: Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer. Miles Laboratories, Lester E Johnson, January 29, 1985: US04496689 (448 worldwide citation)

There is disclosed a process for producing a covalently attached alpha-1-proteinase inhibitor - water soluble polymer complex useful for pulmonary emphysema therapy, a covalently attached alpha-1-proteinase inhibitor - water soluble polymer complex produced by the process, a composition thereof in a ...


3
Anton H Clemens: Blood glucose control apparatus. Miles Laboratories, Roger N Coe, May 1, 1979: US04151845 (425 worldwide citation)

Apparatus is described for controlling blood glucose concentration in a subject by selected infusion of insulin into the blood stream of such subject, depending upon the general blood glucose concentration. This apparatus comprises in combination sensor means for determining the blood glucose concen ...


4
Bruce J Oberhardt: Multilayer enzyme electrode membrane. Miles Laboratories, Roger N Coe, November 29, 1983: US04418148 (373 worldwide citation)

A contiguous multilayer membrane for use with an electrochemical sensor is prepared comprising a first relatively nonporous dense polymer layer, a second polymer layer less dense and more porous than the first layer, a third layer containing an enzyme and a fourth polymer layer less dense and more p ...


5
Paul A D Orazio, Arthur R Eddy Jr, Eric J Fogt, James E Jones, Bruce J Oberhardt: Enzyme electrode membrane. Miles Laboratories, Roger N Coe, November 15, 1983: US04415666 (297 worldwide citation)

A membrane for electrochemical analysis is described comprising a first, relatively dense and thin layer and a second, relatively porous thick layer, which thick layer has dispersed therethrough the enzyme, glucose oxidase. The process of making the membrane by casting two to three layers of cellulo ...


6
Wei jen Kung, Paul O Vogelhut: Polymer catalyst transducers. Miles Laboratories, Roger N Coe, December 24, 1985: US04560534 (266 worldwide citation)

Polymer-catalyst transducers are used for detecting one or more constituents in a sample. Changes in conductivity of the polymer-catalyst transducers as a result of electron density changes are measured to provide an indication of a particular constituent present in the sample. Such conductivity cha ...


7
Giovanni Berti, William I White, Rodric H White Stevens: Test means and method for interference resistant determination of oxidizing substances. Miles Laboratories, Charles J Herron, January 27, 1981: US04247297 (258 worldwide citation)

Test means, such as a composition or device, method of making a test device and process for determination of at least one oxidizing substance, such as a peroxide, are disclosed. More particularly, the contemplated test means comprises a hydrazone and 8-amino-1-napthol-5,7-disulfonic acid (Chicago ac ...


8
Shuenn tzong Chen, Mark J Sherwood, Mary E Warchal: High glucose-determining analytical element. Miles Laboratories, Roger N Coe, January 24, 1984: US04427770 (256 worldwide citation)

An analytical element for quantitatively determining high levels of glucose in blood is made by (a) impregnating a carrier with a first solution, having dissolved therein 4-aminoantipyrine and 3-hydroxy-2,4,6-triiodobenzoic acid or 3,5-dichloro-2-hydroxy-benzene sulfonic acid or salts thereof, a glu ...


9
Robert Bauer: Method and device for detecting glucose concentration. Miles Laboratories, James D McNeil, June 28, 1983: US04390621 (247 worldwide citation)

A method and test device for determining the glucose concentration in a test sample containing from 1/2 to 10 percent glucose are disclosed. The method and test device involve impregnating the carrier with an enzymatic testing composition which includes glucose oxidase, peroxidase and a chromogen. T ...


10
A H Clemens, David L Hough: Blood glucose control apparatus and method. Miles Laboratories, Roger N Coe, August 7, 1984: US04464170 (163 worldwide citation)

In a method and apparatus for controlling the concentration of glucose in the blood stream of a subject at a desired level (BI) including controlling the supply of insulin (IR) by periodically measuring the blood glucose concentration (G) and selecting a predetermined basal infusion rate (RI) for th ...