1
Cochran Mark A, Smith Gale E, Volvovitz Franklin: Polypeptides derived from the envelope gene of human immunodeficiency virus in recombinant baculovirus infected insect cells.. Microgenesys, May 4, 1988: EP0265785-A2 (23 worldwide citation)

The baculovirus-insect cell vector system is used as a high efficiency eukaryotic cloning and expression method for the production of recombinant proteins. A major application of this system is also in the development of rDNA vaccines for a variety of important human and animal diseases. This system ...


2
Cochran Mark A: Method for producing selected polypeptides in virally infected insect cells and polypeptides isolated therefrom.. Microgenesys, July 8, 1987: EP0228036-A2 (13 worldwide citation)

A method for producing in a suitable insect host cell a selected polypeptide which comprises isolating a first DNA segment including a viral promoter from a virus capable of infecting said insect host cell, isolating from a suitable source a second DNA segment containing the sequence encoding said p ...


3
Volvovitz Franklin: A kit or composition for the prevention or treatment of hiv-1 infections.. Microgenesys, September 5, 1990: EP0385909-A2 (11 worldwide citation)

The administration of CD4, particularly soluble CD4 and its derivatives, and the associated administration of immunogenic HIV-1 protein or vaccine material provides a useful procedure for the prevention and/or treatment of HIV-1 infections.


4
Smith Gale E, Cochran Mark A, Volvovitz Franklin: Vaccine containing polypeptides derived from the envelope gene of human immunodeficiency virus type 1.. Microgenesys, August 9, 1989: EP0327180-A2 (10 worldwide citation)

An Acquired Immunodeficiency Syndrome (AIDS) vaccine containing the Human Immunodeficiency Virus, Type-1 (HIV-1) envelope proteins is produced from cloned HIV-1 envelope genes in a baculovirus-inset cell vector system. The recombinant HIV-1 proteins are purified, assembled into particles and then ad ...


5
Cochran Mark A, Smith Gale E, Volvovitz Franklin: Method for producing recombinant protein derived from the circumsporozoite gene of plasmodium falciparum.. Microgenesys, August 23, 1989: EP0329257-A2 (8 worldwide citation)

The baculovirus-insect cell vector system is useful as a high efficiency eukaryotic cloning and expression method for the production of the recombinant proteins. A major application of this system is in the development of rDNA vaccines for important human and animal diseases. This system is also use ...


6
Volvovitz Franklin: Skin test and test kit for aids.. Microgenesys, May 30, 1990: EP0370573-A2 (5 worldwide citation)

A method for the detection of AIDS virus infection in humans involves the introduction of an effective amount of an immunogenic AIDS virus envelope protein intradermally into a human and the subsequent observation of the injection site for an immune response, such as a characteristic redness or swel ...


7
Cochran Mark A, Smith Gale E, Volvovitz Franklin: Strips containing the gp160 envelope protein of the aids virus/hiv, and its use in the detection of the aids antibody.. Microgenesys, October 26, 1988: EP0288093-A2

Nitrocellulose strips having recombinant HIV envelope glycoprotein, HIV gp160, spotted and fixed thereon are useful for the detection of antibody to AIDS virus (HIV). A dye, such as coomassie blue, non-covalently attached to the glycoprotein and to the strip is usefully associated with the glycoprot ...


8
Cochran Mark A, Smith Gale E, Volvovitz Franklin: Bandes contenant la proteine gp160 de lenveloppe du virus du sida et utilisation de celle-ci pour la detection de lanticorps du sida, Hiv gp160 aids virus envelope protein-containing strips and use thereof for detection of aids antibody. Microgenesys, CASSAN MACLEAN, CA1306191

ABSTRACT OF THE DISCLOSURE Nitrocellulose strips having recombinant HIV envelope glycoprotein, HIV gp160, spotted and fixed thereon are useful for the detection of antibody to AIDS virus (HIV). A dye, such as coomassie bluer non-covalently attached to the glycoprotein and to the strip is usefully as ...


9
Franklin Volvovitz, Gale E Smith, Mark A Cochran: Polypeptides derived from envelope gene of human immunodeficiency virus in recombinant baculovirus infected insect cells. Microgenesys, West Haven, Connecticut 06516, Usa, YANG JIUCHANG, December 21, 1988: CN87107837

The baculovirus-insect cell vector system is used as a high efficiency eukaryotic cloning and expression method for the production of recombinant proteins. A major application of this system is also in the development of rDNA vaccines for a variety of important human and animal diseases. This system ...


10
Franklin Volvovitz: Skin test and test kit for aids. Microgenesys, YANG JIUCHANG, June 20, 1990: CN89109558

A method for the detection of AIDS virus infection in humans involves the introduction of an effective amount of an immunogenic AIDS virus envelope protein intradermally into a human and the subsequent observation of the injection site for an immune response, such as a characteristic redness or swel ...



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