1
John T Santini Jr, Charles E Hutchinson, Scott A Uhland, Michael J Cima, Robert S Langer, Dennis Ausiello: Microfabricated devices for the delivery of molecules into a carrier fluid. MicroChips, Sutherland Asbill & Brennan, December 10, 2002: US06491666 (255 worldwide citation)

Apparati and methods are provided for the delivery of molecules to a site via a carrier fluid. The apparati include microchip devices which have reservoirs containing the molecules for release. The apparati and methods provide for active or passive controlled release of the molecules. Preferred embo ...


2
John T Santini Jr, Charles E Hutchinson: Implantable drug delivery stents. MicroCHIPS, Sutherland Asbill & Brennan, December 2, 2003: US06656162 (245 worldwide citation)

Devices for the controlled release of one or more drugs are provided. The devices include an implantable stent, at least two reservoirs in the stent, and a release system contained in each of the at least two reservoirs, wherein the release system comprises one or more drugs for release.


3
Scott A Uhland, Benjamin F Polito, Stephen J Herman, John T Santini Jr, John M Maloney: Methods for hermetically sealing microchip reservoir devices. MicroCHIPS, Sutherland Asbill & Brennan, December 7, 2004: US06827250 (186 worldwide citation)

Methods are provided for hermetically sealing the reservoirs of microchip devices and for hermetically sealing the substrate assemblies in a hermetic packaging structure. In one embodiment, the method comprises (1) providing a primary substrate having a front side and a back side, the substrate comp ...


4
Norman F Sheppard Jr, John T Santini Jr, Stephen J Herman, Michael J Cima, Robert S Langer, Dennis Ausiello: Microchip reservoir devices using wireless transmission of power and data. MicroCHIPS, Sutherland Asbill & Brennan, June 5, 2007: US07226442 (169 worldwide citation)

Devices, systems, and methods are provided for wirelessly powering and/or communicating with microchip devices used for the controlled exposure and release of reservoir contents, such as drugs, reagents, and sensors. In one embodiment, the system includes (1) a microchip device comprising a substrat ...


5
John T Santini Jr, Norman F Sheppard Jr, Chung Chang Young, Robert S Langer: Microfabricated devices for the storage and selective exposure of chemicals and devices. MicroCHIPS, Sutherland Asbill & Brennan, April 22, 2003: US06551838 (163 worldwide citation)

Microchip devices are provided which include a substrate having a plurality of reservoirs containing a secondary device, a reacting component, or a combination thereof. At least one barrier layer covers each reservoir to isolate the reservoir contents from one or more environmental components outsid ...


6
John T Santini Jr, Michael J Cima, Scott Albert Uhland: Thermally-activated microchip chemical delivery devices. MicroCHIPS, Sutherland Asbill & Brennan, December 30, 2003: US06669683 (147 worldwide citation)

Microchip delivery devices are provided that control both the rate and time of release of molecules. In one embodiment, an implantable microchip device is provided for the controlled delivery of drug molecules into a patient comprising at least one substrate; a plurality of reservoirs in the substra ...


7
Norman F Sheppard Jr, Christina M Feakes, John T Santini Jr: Microchip reservoir devices and facilitated corrosion of electrodes. MicroCHIPS, Sutherland Asbill & Brennan, August 10, 2004: US06773429 (144 worldwide citation)

Methods and devices are provided for enhancing corrosion of an electrode in a biocompatible fluid. The method comprises (1) placing a primary electrode and a counter electrode in an electroconductive biocompatible fluid to form an electrochemical cell; and (2) applying a time-varying potential, thro ...


8
John T Santini Jr, Charles E Hutchinson, Scott A Uhland, Michael J Cima, Robert S Langer, Dennis Ausiello: Microfabricated devices for the delivery of molecules into a carrier fluid. MicroCHIPS, Sutherland Asbill & Brennan, March 25, 2003: US06537256 (126 worldwide citation)

Apparatus and methods are provided for the delivery of molecules to a site via a carrier fluid. The apparatus include microchip devices which have reservoirs containing the molecules for release. The apparatus and methods provide for active or passive controlled release of the molecules. Embodiments ...


9
Norman F Sheppard Jr, Christina M Feakes: Methods for conformal coating and sealing microchip reservoir devices. MicroCHIPS, Sutherland Asbill & Brennan, December 13, 2005: US06973718 (122 worldwide citation)

Methods are provided for conformally coating microchip devices and for sealing reservoirs containing molecules or devices in a microchip device. One method comprises (i) providing a substrate having a plurality of reservoirs having reservoir openings in need of sealing; (ii) loading reservoir conten ...


10
John T Santini Jr, Michael J Cima, Scott Albert Uhland: Thermally-activated microchip chemical delivery devices. MicroCHIPS, Sutherland Asbill & Brennan, March 4, 2003: US06527762 (104 worldwide citation)

Microchip delivery devices are provided that control both the rate and time of release of molecules, wherein the device includes a substrate, at least one reservoir in the substrate containing the molecules, and a reservoir cap positioned on the reservoir over the molecules, wherein the molecules ar ...



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