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Gale Eugene Smith, Franklin Volvovitz, Bethanie Eident Wilkinson, Craig Stanway Hackett: Method for producing influenza hemagglutinin multivalent vaccines using baculovirus. MG PMC, Thomas J Kowalski, Curtis Morris & Safford PC, June 9, 1998: US05762939 (80 worldwide citation)

A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a trivalent influenza vaccine based on a mixture of recombinant hemagglutinin antigens cloned from influenza viruses having epidemic potential. The recombinant hemagglutinin antigens are ...


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Smith Gale Eugene, Volvovitz Franklin, Wilkinson Bethanie E, Voznesensky Andrei I, Hackett Craig Stanway: A vector and method for producing influenza hemagglutinin. Mg Pmc, April 8, 1998: EP0833933-A1 (7 worldwide citation)

A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a multivalent, preferably trivalent, influenza vaccine based on a mixture of recombinant hemagglutinin antigens cloned from influenza viruses having epidemic potential. The recombinant he ...


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Smith Gale Eugene, Volvovitz Franklin, Wilkinson Bethanie E, Voznesensky Andrei I, Hackett Craig Stanway: A method for producing influenza hemagglutinin multivalent vaccines. Mg Pmc, December 14, 2005: EP1605052-A2 (2 worldwide citation)

A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a multivalent, preferably trivalent, influenza vaccine based on a mixture of recombinant hemagglutinin antigens cloned from influenza viruses having epidemic potential. The recombinant he ...


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Smith Gale Eugene, Volvovitz Franklin, Wilkinson Bethanie E, Voznesensky Andrei I, Hackett Craig Stanway: A method for producing influenza hemagglutinin multivalent vaccines. Mg Pmc, January 15, 2003: EP1275726-A2

A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a multivalent, preferably trivalent, influenza vaccine based on a mixture of recombinant hemagglutinin antigens cloned from influenza viruses having epidemic potential. The recombinant he ...


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G・e・史密斯, F・沃尔沃维茨, B・e・维尔金森, A・i・沃兹内森斯基, C・s・哈克特: 生产流感血凝素多价疫苗的方法. Mg-pmc有限公司, 罗宏, 姜建成, 中国专利代理, September 23, 1998: CN95197928.0

本发明提供了使用DNA技术制备重组流感疫苗的方法。所产生的疫苗是多价的,优选三价的,基于从具有流行潜能的流感病毒克隆的重组血凝素抗原混合物的流感疫苗。重组的血凝素抗原为全长的,未被切割的(HAO),从培养昆虫细胞内的杆状病毒表达载体产生,并在非变性的条件下纯化的糖蛋白。在优选的实施方案中,通过切除天然的疏水信号肽序列并代之以一个新的杆状病毒几丁质酶信号肽来对克隆的HA基因进行修饰。还公开了用于从A亚型和B型流感病毒中纯化rHA蛋白的有效提取和纯化从昆虫细胞中产生的重组HA蛋白的一般方法。


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G E Smith, F Volvovitz, B E Wilkinson: Method for producing influenza hemagglutinin multivalent vaccines. Mg Pmc, L L C, luo hong, September 23, 1998: CN95197928

A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a multivalent, preferably trivalent, influenza vaccine based on a mixture of recombinant hemagglutinin antigens cloned from influenza viruses having epidemic potential. The recombinant he ...


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Smith Gale Eugene, Volvovitz Franklin, Wilkinson Bethanie E, Voznesensky Andrei I, Hackett Craig Stanway: A method for producing influenza hemagglutinin multivalent vaccines. Mg Pmc, KOWALSKI Thomas J, November 28, 1996: WO/1996/037624

A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a multivalent, preferably trivalent, influenza vaccine based on a mixture of recombinant hemagglutinin antigens cloned from influenza viruses having epidemic potential. The recombinant he ...


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Gesmith, Fvolvovitz, Bewilkinson, Aivoznesensky, Cshackett: Method for producing influenza hemagglutinin multivalent vaccine. Mg Pmc, liu yue, January 28, 2009: CN200810090164

The invention relates to a method for producing a polyvalent vaccine of an influenza hemagglutinin. The invention provides a method for preparing a recombined influenza vaccine by using the technology of DNA. The produced vaccine is polyvalent, preferably to be trivalent and is based on the influenz ...


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