1
Simon F Williams, David P Martin, Frank A Skraly: Medical devices and applications of polyhydroxyalkanoate polymers. Metabolix, Pabst Patent Group, January 4, 2005: US06838493 (295 worldwide citation)

Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including int ...


2
David P Martin, Frank Skraly, Simon F Williams: Polyhydroxyalkanoate compositions having controlled degradation rates. Metabolix, Pabst Patent Group, March 15, 2005: US06867248 (219 worldwide citation)

Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant ...


3
Simon F Williams, David P Martin, Frank A Skraly: Medical devices and applications of polyhydroxyalkanoate polymers. Metabolix, Holland & Knight, April 15, 2003: US06548569 (182 worldwide citation)

Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including int ...


4
Simon F Williams, David P Martin, Tillman Gerngross, Daniel M Horowitz: Removing endotoxin with an oxdizing agent from polyhydroxyalkanoates produced by fermentation. Metabolix, Arnall Golden & Gregory, June 12, 2001: US06245537 (127 worldwide citation)

Polyhydroxyalkanoate (PHA) that contains a pyrogen such as endotoxin due to a process of producing the PHA is treated to remove the pyrogen by a process that does not affect the inherent chemical and physical properties of the PHA to obtain a biocompatible PHA. PHA produced by fermentation with a Gr ...


5
Simon F Williams, David P Martin, Frank A Skraly: Medical devices and applications of polyhydroxyalkanoate polymers. Metabolix, Pabst Patent Group, March 15, 2005: US06867247 (103 worldwide citation)

Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including int ...


6
Gjalt W Huisman, Frank Skraly, David P Martin, Oliver P Peoples: Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids. Metabolix, Holland & Knight, November 13, 2001: US06316262 (102 worldwide citation)

The gene encoding a 4-hydroxybutyryl-Co A transferase has been isolated from bacteria and integrated into the genome of bacteria also expressing a polyhydroxyalkanoate synthase, to yield an improved production process for 4HB-containing polyhydroxyalkanoates using transgenic organisms, including bot ...


7
David P Martin, Frank Skraly, Simon F Williams: Polyhydroxyalkanoate compositions having controlled degradation rates. Metabolix, Holland & Knight, August 26, 2003: US06610764 (85 worldwide citation)

Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant ...


8
David P Martin, Frank Skraly, Simon F Williams: Polyhydroxyalkanoate compositions having controlled degradation rates. Metabolix, Pabst Patent Group, December 7, 2004: US06828357 (81 worldwide citation)

Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant ...


9
Gjalt W Huisman, Frank Skraly, David P Martin, Oliver P Peoples: Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids. Metabolix, Holland & Knight, February 10, 2004: US06689589 (64 worldwide citation)

The gene encoding a 4-hydroxybutyryl-Co A transferase has been isolated from bacteria and integrated into the genome of bacteria also expressing a polyhydroxyalkanoate synthase, to yield an improved production process for 4HB-containing polyhydroxyalkanoates using transgenic organisms, including bot ...


10
Oliver P Peoples, Tillman U Gerngross, Anthony J Sinskey: Overproduction and purification of soluble PHA synthase. Massachusetts Institute of Technology and Metabolix, Arnall Golden & Gregory, January 2, 1996: US05480794 (64 worldwide citation)

Purified, soluble recombinant bacterial long chain and short chain PHA synthases are described, with methods and materials for overexpression and purification.