1
Kolb Michael, Burkhart Joseph P, Jung Michel J, Gerhart Fritz E, Giroux Eugene L, Schirlin Daniel G, Neises Bernhard: Novel peptidase inhibitors.. Merrell Dow Pharma, September 24, 1986: EP0195212-A2 (127 worldwide citation)

This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of ...


2
Bey Philippe, Angelastro Michael, Mehdi Shujaath: Novel peptidase inhibitors.. Merrell Dow Pharma, April 11, 1990: EP0363284-A2 (98 worldwide citation)

This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide gorup of the substrate peptide has been replaced by H or a substituted carbonyl moiety. The contemplated peptidase inhibitors of the foregoing enzymes are selected from the generic formula R1NH ...


3
Bey Philippe, Angelastro Michael, Mehdi Shujaath: Novel peptidase inhibitors.. Merrell Dow Pharma, April 18, 1990: EP0364344-A2 (90 worldwide citation)

This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide group of the substrate peptide has been replaced by a substituted malonyl moiety. The contemplated peptidase inhibitors of the foregoing enzymes are selected from the generic formula the hydrat ...


4
Bey Philippe, Peet Norton P, Angelastro Michael R, Mehdi Shujaath: Novel peptidase inhibitors.. Merrell Dow Pharma, January 30, 1991: EP0410411-A2 (81 worldwide citation)

This invention relates to activated electrophilic ketone analogs of certain peptidase substrates which are useful in inhibiting serine-, carboxylic acid- and metallo- proteolytic enzymes, the inhibition of which will have useful physiological consequences in a variety of disease states.


5

6
Whitten Jeffrey P, Lambert Laurie E, Mcdonald Ian A, Doherty Niall S: Inhibitors of nitric oxide biosynthesis.. Merrell Dow Pharma, September 18, 1991: EP0446699-A1 (64 worldwide citation)

The present invention is directed to a new class of compound which are useful as inhibitors of the biosynthesis of nitric oxide.


7
Warshawsky Alan M, Flynn Gary A: Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace.. Merrell Dow Pharma, March 31, 1993: EP0534363-A2 (50 worldwide citation)

The present invention relates to novel 2-substituted indane-2-mercaptoacetylaminde derivatives which are useful as inhibitors of enkephalinase and ACE.


8
Halazy Serge, Danzin Charles: 9-purinyl phosphonic acid derivatives.. Merrell Dow Pharma, January 8, 1992: EP0465297-A1 (50 worldwide citation)

This invention relates to novel purine nucleoside phosphorylase inhibitors, to the methods and intermediates for their preparation and to their use as immunosuppressants, antilymphoma, antileukemic, antiviral and antiprotozoal agents.


9
Flynn Gary A, Beight Douglas W: Novel antihypertensive agent.. Merrell Dow Pharma, December 16, 1987: EP0249223-A2 (49 worldwide citation)

This invention relates to derivatives of fused tricyclic lactams, of the formula: to the intermediates and processes useful for their preparation and to their pharmacological effect in inhibiting the angiotensin converting enzyme and to their end-use application in the treatment of hypertension.


10
Peet Norton P, Angelastro Michael R, Burkhart Joseph P: Novel orally-active elastase inhibitors.. Merrell Dow Pharma, March 3, 1993: EP0529568-A1 (48 worldwide citation)

This invention relates to novel morpholinourea and related derivatives of pentafluoroethyl peptides which are orally active elastase inhibitors. Pharmaceutical compositions containing these compounds are useful in the treatment of various inflammatory diseases and emphysema.