1
Kirk Patrick Seward, Isidro M Gandionco, David Gandionco: Dual modulus balloon for interventional procedures. Mercator Medsystems, Townsend and Townsend and Crew, April 6, 2010: US07691080 (119 worldwide citation)

A device for interventional surgical or medical procedures is presented. The device is generally in the form of a balloon and is used to position itself or other working elements up against or through lumen walls in the body. The balloon is comprised of at least two materials of different elastic mo ...


2
Kirk Patrick Seward: Catheters having laterally deployable needles. Mercator Medsystems, Townsend and Townsend abd Crew, November 28, 2006: US07141041 (41 worldwide citation)

A needle injection catheter comprises a catheter body having an axially disposed needle near its distal end. The needle passes through a deflection path formed in a distal nose of the catheter. A deflection path typically comprises a 90° turn so that the axially disposed needle can be deflected late ...


3
Kirk Patrick Seward: Treatment of renal hypertension or carotid sinus syndrome with adventitial pharmaceutical sympathetic denervation or neuromodulation. Mercator Medsystems, Wilson Sonsini Goodrich & Rosati, June 18, 2013: US08465752 (39 worldwide citation)

Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population. Hypertension can be treated with neuromodulating ag ...


4
Kirk Patrick Seward, Lynn Mateel Barr, Judith Carol Wilber, Robert Cafferata: Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation. Mercator MedSystems, Townsend and Townsend and Crew, June 29, 2010: US07744584 (39 worldwide citation)

Methods and kits for delivering pharmaceutical agents to the adventitia and other regions outside the external elastic lamina (EEL) surrounding a blood vessel utilize a catheter having a needle. The needle is positioned in up to 5 mm beyond the EEL and delivers an amount of pharmaceutical agent suff ...


5
Kirk Patrick Seward: Treatment of hypertension by renal vascular delivery of guanethidine. Mercator Medsystems, Wilson Sonsini Goodrich & Rosati, March 19, 2013: US08399443 (28 worldwide citation)

Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population. Hypertension can be treated with neuromodulating ag ...


6
Kirk Patrick Seward, Lynn Mateel Barr, Judith Carol Wilber, Robert Cafferata: Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation. Mercator MedSystems, Wilson Sonsini Goodrich & Rosati, April 29, 2014: US08708995 (27 worldwide citation)

Methods and kits for delivering pharmaceutical agents to the adventitia and other regions outside the external elastic lamina (EEL) surrounding a blood vessel utilize a catheter having a needle. The needle is positioned in up to 5 mm beyond the EEL and delivers an amount of pharmaceutical agent suff ...


7
Kirk Patrick Seward: Treatment of renal hypertension or carotid sinus syndrome with heated fluid sympathetic denervation or neuromodulation. Mercator MedSystems, Wilson Sonsini Goodrich & Rosati, April 21, 2015: US09011879 (22 worldwide citation)

Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population. Hypertension can be treated with neuromodulating ag ...


8
Seward Kirk Patrick: Use of guanethidine for treating hypertension by local vascular delivery. MERCATOR MEDSYSTEMS, Heslin James M, October 28, 2010: WO/2010/124120 (20 worldwide citation)

Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population. Hypertension can be treated with neuromodulating ag ...


9
Kirk Patrick Seward, Isidro M Gandionco, David Gandionco: Dual modulus balloon for interventional procedures. Mercator MedSystems, Wilson Sonsini Goodrich & Rosati, September 13, 2011: US08016786 (19 worldwide citation)

A device for interventional surgical or medical procedures is presented. The device is generally in the form of a balloon and is used to position itself or other working elements up against or through lumen walls in the body. The balloon is comprised of at least two materials of different elastic mo ...


10
Kirk Patrick Seward: Electroporation microneedle and methods for its use. Mercator MedSystems, Townsend&Townsend&CrewLLC, October 24, 2006: US07127284 (19 worldwide citation)

Electroporation of cells in target tissues is performed using microneedles having integral electrode structures. In a first embodiment, a pair of electrode structures are disposed on opposite sides of a substance delivery opening on a needle or other tissue-penetrating shaft. In a second embodiment, ...