1
Gregory DeBaryshe, Mark Modell, A Ze ev Hed: Spectral volume microprobe analysis of materials. MediSpectra, Wolf Greenfield & Sacks P C, February 3, 1998: US05713364 (119 worldwide citation)

An optical probe collects light responses from a specimen that selectively and preferentially emanates from a localized volume element within the sample, with illumination irradiance and collection efficiency both dropping off away from the localized volume element, and a processor applies a vector ...


2
Christopher E Griffin, Chunsheng Jiang, Jean Pierre Schott, Kevin T Schomacker, Ross F Flewelling, Charles C Abele: Methods and apparatus for displaying diagnostic data. MediSpectra, Goodwin Procter, November 14, 2006: US07136518 (106 worldwide citation)

The invention provides methods for displaying diagnostic results obtained from a tissue sample. In general, the invention assigns tissue-class probability values to discrete regions of a patient sample, and creates an overlay for displaying the results. The overlay facilitates display of the tissue ...


3
Mark Modell, A Ze&apos ev Hed: Spectral volume microprobe arrays. Medispectra, Testa Hurwitz & Thibeault, June 25, 2002: US06411835 (93 worldwide citation)

Methods and apparatus are provided for determining a characteristic of a sample of a material by the interaction of electromagnetic radiation with the sample. The apparatus includes a source of electromagnetic radiation, an optical assembly and a detector. The optical assembly sequentially illuminat ...


4
Robert Nordstrom, Mark Modell, Alexander Zelenchuk: Systems and methods for optical examination of samples. Medispectra, Testa Hurwitz & Thibeault, June 25, 2002: US06411838 (76 worldwide citation)

The present invention relates to systems and methods for examining a sample using a substantially monostatic, substantially confocal optical system comprising transmitting optics that focus an illuminating light upon the sample and receiving optics that collect light emitted from the sample followin ...


5
Mark Modell, Gregory DeBaryshe, A Ze ev Hed: Spectral volume microprobe for analysis of materials. MediSpectra, Wolf Greenfield & Sacks P C, September 29, 1998: US05813987 (71 worldwide citation)

An optical probe collects light emanating from a specimen that selectively andpreferentially represents a localized volume element within the sample, with illuminationintensity and collection efficacy both dropping off away from the localized volume element to limit the integrated contribution from ...


6
Robert Nordstrom, David Bee, Mark Modell, Ze ev Hed, Jennie Kwo, Matthew Emans: Optical probe accessory device for use in vivo diagnostic procedures. MediSpectra, Testa Hurwitz & Thibeault, January 25, 2005: US06847490 (62 worldwide citation)

The present invention recognizes that optical probes function both as medical access devices and as instruments which collect complex optical data. The invention provides an optical probe accessory device which can access luminal spaces within the body of a patient without sacrificing the quality of ...


7
Mark Modell, Ze&apos ev Hed, David Bee, David Lipson, Jennie Kwo, Matthew Emans, Robert Nordstrom: Spectral volume microprobe arrays. MediSpectra, Testa Hurwitz & Thibeault, November 30, 2004: US06826422 (59 worldwide citation)

Methods and apparatus are provided for determining a characteristic of a sample of a material by the interaction of electromagnetic radiation with the sample. The apparatus includes an optical assembly and a protective barrier. The optical assembly sequentially illuminates a plurality of volume elem ...


8
Mark Modell, A Ze ev Hed: Spectral volume microprobe arrays. MediSpectra, Foley Hoag & Eliot, August 15, 2000: US06104945 (44 worldwide citation)

Methods and apparatus are provided for determining a characteristic of a sample of a material by the interaction of electromagnetic radiation with the sample. The apparatus includes a source of electromagnetic radiation, an optical assembly and a detector. The optical assembly sequentially illuminat ...


9
Thomas Clune, Philippe Schmid, Chunsheng Jiang: Methods and systems for correcting image misalignment. MediSpectra, Goodwin Procter, March 6, 2007: US07187810 (37 worldwide citation)

The invention provides methods of determining a correction for a misalignment between at least two images in a sequence of images due at least in part to sample movement. The methods are applied, for example, in the processing and analysis of a sequence of images of biological tissue in a diagnostic ...


10
Howard Kaufman, Alex Zelenchuk, Ross Flewelling, Philippe Schmid, Ze ev Hed: Methods of monitoring effects of chemical agents on a sample. MediSpectra, Testa Hurwitz & Thibeault, June 7, 2005: US06902935 (29 worldwide citation)

The invention provides methods and systems for monitoring effects of chemical agents on optical signals produced by samples in response to the chemical agents. Preferred methods comprise application of multiple chemical agents that interact to alter an optical signal from the sample. Methods and sys ...