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Ronaldus Adrianus Maria Fouchier, Bernadetta Gerarda Van Den Hoogen, Albertus Dominicus Marcellinus Erasmus Osterhaus, Aurelia Haller, Roderick Tang: Metapneumovirus strains and their use in vaccine formulations and sequences. ViroNovative, MedImmune Vaccines, TraskBritt P C, May 13, 2014: US08722341 (28 worldwide citation)

Provided is an isolated mammalian negative strand RNA virus, metapneumovirus (MPV). Described are isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. Also described is mammalian MPV, subgroups ...


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Peter Palese, Adolfo Garcia Sastre: Recombinant negative strand RNA virus expression systems and vaccines. MedImmune Vaccines, Paul Littlepage, Jonathan Klein Evans, Quine Intellectual Property Law Group P C, May 3, 2005: US06887699 (26 worldwide citation)

Recombinant negative-strand viral RNA templates are described which may be used with purified RNA-directed RNA polymerase complex to express heterologous gene products in appropriate host cells and/or to rescue the heterologous gene in virus particles. The RNA templates are prepared by transcription ...


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Vu Truong Le, Binh Pham: Preservation of bioactive materials by spray drying. MedImmune Vaccines, Gary Baker, Quine Intellectual Property Law Group P C, August 21, 2007: US07258873 (17 worldwide citation)

This invention provides methods and compositions to preserve bioactive materials in a matrix of powder particles. Methods provide high-pressure gas spraying and/or near supercritical spraying of formulations followed by drying in a stream of conditioned gas to form stable powder particles containing ...


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Richard Schwartz, John Michael Berry, Weidong Cui: Methods of producing influenza vaccine compositions. MedImmune Vaccines, August 28, 2007: US07262045 (17 worldwide citation)

Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.


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Hoffmann Erich, Jin Hong, Lu bin, Duke Gregory, Kemble George, Chen Zhongying: Multi plasmid system for the production of influenza virus. Medimmune Vaccines, Hoffmann Erich, Jin Hong, Lu bin, Duke Gregory, Kemble George, Chen Zhongying, ALBAN Patrick Scott, December 8, 2005: WO/2005/115448 (14 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing ...


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Vu Truong Le: Preservation of bioactive materials by freeze dried foam. MedImmune Vaccines, Quine Intellectual Property Law Group P C, Gary Baker, November 14, 2006: US07135180 (13 worldwide citation)

This invention provides methods and compositions to preserve bioactive materials in a dried foam matrix. Methods provide non-boiling foam generation and penetration of preservative agents at temperatures near the phase transition temperature of the membranes.


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Kemble George, Trager George, Schwartz Richard: Refrigerator-temperature stable influenza vaccine compositions. Medimmune Vaccines, Kemble George, Trager George, Schwartz Richard, PATRICK Scott Alban, April 20, 2006: WO/2006/041819 (13 worldwide citation)

Methods and compositions for the optimization and production of refrigerator-temperature stable virus, e.g., influenza, compositions are provided. Formulations and immunogenic compositions comprising refrigerator-temperature stable virus compositions are provided.


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Truong Le Vu, Scherer Tom: High pressure spray-dry of bioactive materials. Medimmune Vaccines, Truong Le Vu, Scherer Tom, QUINE Jonathan Alan, July 15, 2004: WO/2004/058156 (13 worldwide citation)

This invention provides compositions and methods providing, e.g., stable powder particles containing bioactive materials. The methods include, e.g., high pressure spraying of the bioactive materials in solution or suspension, with viscosity enhancing agents and/or surfactants. Compositions of the in ...


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