1
Gregory P Winter: Recombinant altered antibodies and methods of making altered antibodies. Medical Research Council, Spencer Frank & Schneider, July 6, 1993: US05225539 (1061 worldwide citation)

An altered antibody is produced by replacing the complementarity determining regions (CDRs) of a variable region of an immunoglobulin (Ig) with the CDRs from an Ig of different specificity, using recombinant DNA techniques. The gene coding sequences for producing the altered antibody may be produced ...


2
Azim M Surani, Michael S Neuberger, Marianne Bruggemann: Production of antibodies from transgenic animals. The Babraham Institute, Medical Research Council, Cushman Darby and Cushman, August 13, 1996: US05545807 (870 worldwide citation)

Chimaeric or wholly foreign immunoglobulin is obtained from cells or body fluid of a transgenic animal which has had inserted into its germline genetic material that encodes for at least part of an immunoglobulin, of foreign origin or that can rearrange to encode a repertoire of immunoglobulins, i.e ...


3
Hendricus R J M Hoogenboom, Michael Baier, Laurent S A T Jespers, Gregory P Winter: Production of chimeric antibodies - a combinatorial approach. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, October 15, 1996: US05565332 (754 worldwide citation)

Methods are disclosed which may be used for the production of antibodies, or antibody fragments, which have the same binding specificity as a parent antibody but which have increased human characteristics. Humanized antibodies may be obtained by chain shuffling, perhaps using phage display technolog ...


4
John McCafferty, Anthony Richard Pope, Kevin Stuart Johnson, Henricus Renerus Jacobus Mattheus Hoogenboom, Andrew David Griffiths, Ronald Henry Jackson, Kaspar Philipp Holliger, James David Marks, Timothy Piers Clackson, David John Chiswell, Gregory Paul Winter, Timothy Peter Bonnert: Methods for producing members of specific binding pairs. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, October 19, 1999: US05969108 (512 worldwide citation)

A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containi ...


5
Kevin Stuart Johnson, Gregory Paul Winter, Andrew David Griffiths, Andrew John Hammond Smith, Peter Michael Waterhouse: Methods for producing members of specific binding pairs. Cambridge Antibody Technology, Medical Research Council, Marshall O Toole Gerstein Murray & Borun, March 31, 1998: US05733743 (501 worldwide citation)

Methods, recombinant host cells and kits are disclosed for the production of members of specific binding pairs (sbp), e.g. antibodies, using display on the surface of secreted replicable genetic display packages (rgdps), e.g. filamentous phage. To produce a library of great diversity, recombination ...


6
Andrew David Griffiths, Hendricus Renerus Jacobus Mattheus Hoogenboom, James David Marks, John McCafferty, Gregory Paul Winter, Geoffrey Walter Grigg: Production of anti-self antibodies from antibody segment repertoires and displayed on phage. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, March 23, 1999: US05885793 (294 worldwide citation)

Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self-antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such as filamentous ...


7
William L Bro: Method and apparatus for an automated and interactive behavioral guidance system. National Medical Research Council, Cislo & Thomas, December 27, 1994: US05377258 (264 worldwide citation)

An automated and interactive positive motivation system (10) that allows a doctor or trainer to produce and send a series of motivational messages and/or questions to a client (50) to motivate or reinforce a specific behavioral problem. The system (2) consists of a client database (12) that includes ...


8
Yen Choo, Aaron Klug, Isidro Sanchez Garcia: Binding proteins for recognition of DNA. Medical Research Council, Pillsbury Madison & Sutro Cushman Darby & Cushman IP Group, December 28, 1999: US06007988 (216 worldwide citation)

Disclosed are libraries of DNA sequences encoding zinc finger binding motifs for display on a particle, together with methods of designing zinc finger binding polypeptides for binding to a particular target sequence and, inter alia, use of designed zinc finger polypeptides for various in vitro or in ...


9
Yen Choo, Aaron Klug, Isidro Sanchez Garcia: Binding proteins for recognition of DNA. Medical Research Council, Pillsbury Madison & Sutro, January 11, 2000: US06013453 (210 worldwide citation)

Disclosed are libraries of DNA sequences encoding zinc finger binding motifs for display on a particle, together with methods of designing zinc finger binding polypeptides for binding to a particular target sequence and, inter alia, use of designed zinc finger polypeptides for various in vitro or in ...


10
Kaspar Philipp Holliger, Andrew David Griffiths, Hendricus Renerus Jacobus Matheus Hoogenboom, Magnus Malmqvist, James David Marks, Brian Timothy McGuinness, Anthony Richard Pope, Terence Derek Prospero, Gregory Paul Winter: Multivalent and multispecific binding proteins, their manufacture and use. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, November 17, 1998: US05837242 (201 worldwide citation)

Polypeptides comprising a first domain, which comprises a binding region of an immunoglobulin heavy chain variable region, and a second domain, which comprises a binding region of an immunoglobulin light chain variable region, the domains being linked but incapable of associating with each other to ...