1
Yashwant M Deo, Joel Goldstein, Robert Graziano, Chezian Somasundaram: Therapeutic compounds comprised of anti-Fc receptor antibodies. Medarex, Lahive & Cockfield, November 17, 1998: US05837243 (137 worldwide citation)

Multispecific multivalent molecules which are specific to an Fc receptor (FcR), and therapeutic uses and therapeutic uses and methods for making the molecules are described.


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Peter J Kelleher: Modulation of cell proliferation and wound healing. Medarex, Jane E Remillard Esq, Megan E Williams, Lahive & Cockfield, May 16, 2000: US06063116 (108 worldwide citation)

Intraocular devices which are capable of sustained release of a cell proliferation modulating agent, together with methods for their preparation and use, are provided. The proliferation modulating agent is associated either covalently or non-covalently with the material from which the intraocular de ...


4
Alan J Korman, Mohan Srinivasan, Changyu Wang, Mark J Selby, Bingliana Chen, Josephine M Cardarelli: Human monoclonal antibodies to programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics. Medarex, Ono Pharmaceutical, Baker Botts L, August 30, 2011: US08008449 (87 worldwide citation)

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the ...


5
J G J van de Winkel: Transgenic mice expressing human Fc.alpha. and .beta. receptors. Medarex Incorporated, Jane E Remillard Esq, Giulio A DeConti Jr Esq, Lahive & Cockfield, August 29, 2000: US06111166 (74 worldwide citation)

Transgenic animals expressing Fc receptors and uses for the animals in testing the efficacy of human antibodies and in generating novel antibodies are described.


6
Alan J Korman, Edward L Halk, Nils Lonberg, Yashwant M Deo, Tibor P Keler: Human CTLA-4 antibodies. Medarex, Darby & Darby, January 10, 2006: US06984720 (70 worldwide citation)

The present invention provides human sequence antibodies against CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.


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Yashwant M Deo, Joel Goldstein, Robert Graziano, Chezian Somasundaram: Therapeutic compounds comprised of anti-Fc receptor antibodies. Medarex, Jane E Remillard, Peter W Dini, Lahive & Cockfield, August 7, 2001: US06270765 (70 worldwide citation)

Multispecific multivalent molecules which are specific to an Fc receptor (FcR), and therapeutic uses and therapeutic uses and methods for making the molecules are described.


8
Korman Alan J, Srinivasan Mohan, Wang Changyu, Selby Mark J, Chen Bing, Cardarelli Josephine M: Human monoclonal antibodies to programmed death 1(pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics. Ono Pharmaceutical, Medarex, Korman Alan J, Srinivasan Mohan, Wang Changyu, Selby Mark J, Chen Bing, Cardarelli Josephine M, NAITO Teruo, November 16, 2006: WO/2006/121168 (68 worldwide citation)

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the ...


9
Boyd Sharon, Chen Liang, Gangwar Sanjeev, Guerlavais Vincent, Horgan Kilian, Li Zhi Hong, Sufi Bilal: Self-immolative linkers and drug conjugates. Medarex, Boyd Sharon, Chen Liang, Gangwar Sanjeev, Guerlavais Vincent, Horgan Kilian, Li Zhi Hong, Sufi Bilal, FEHLNER Paul F, December 1, 2005: WO/2005/112919 (64 worldwide citation)

The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine or disulfide self-immolative linker. In a particular embodiment the cytotoxin is represented by duocarmycins and derivatives thereof. The d ...


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Nils Lonberg, Robert M Kay: Transgenic non-human animals for producing chimeric antibodies. Medarex, Baker Botts L, March 10, 2009: US07501552 (60 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.