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Beigelman Leonid, Matulic Adamic Jasenka, Vargeese Chandra, Karpeisky Alexander, Blatt Lawrence, Shaffer Christopher: Conjugates and compositions for cellular delivery. Sirna Therapeutics, Beigelman Leonid, Matulic Adamic Jasenka, Vargeese Chandra, Karpeisky Alexander, Blatt Lawrence, Shaffer Christopher, DOCTER Stephen H, November 28, 2002: WO/2002/094185 (1 worldwide citation)

This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including folate, galactose, galactosamine, N-acetyl galactosamine, PEG, phospholipid, peptide and human serum albumin (HAS) derived conjugates of biologically active compounds, incl ...


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Mcswiggen James, Usman Nassim, Blatt Lawrence, Beigelman Leonid, Burgin Alex, Karpeisky Alexander, Matulic Adamic Jasenka, Sweedler David, Draper Kenneth, Chowrira Bharat, Stinchcomb Dan, Beaudry Amber, Zinnen Shawn, Lugwig Janos, Sproat Brian S: Nucleic acid based modulators of gene expression. Ribozyme Pharmaceuticals, Mcswiggen James, Usman Nassim, Blatt Lawrence, Beigelman Leonid, Burgin Alex, Karpeisky Alexander, Matulic Adamic Jasenka, Sweedler David, Draper Kenneth, Chowrira Bharat, Stinchcomb Dan, Beaudry Amber, Zinnen Shawn, Lugwig Janos, Sproat Brian S, BOEHNEN Daniel, March 8, 2001: WO/2001/016312

Nucleic acid molecules (antisenses or ribozymes) useful as inhibitors of gene expression, especially of HER2, BACE, TERT, PTP-1B, MetAP-2, HBV, phospholamban, presenilin-2 and PKC-alpha. The nucleic acid molecules can be modified in various ways on the sugar and/or base moieties and/or on the phosph ...


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Beigelman Leonid, Burgin Alex, Beaudry Amber, Karpeisky Alexander, Matulic Adamic Jasenka, Sweedler David, Zinnen Shawn: Nucleoside triphosphates and their incorporation into ribozymes. Ribozyme Pharmaceuticals, Beigelman Leonid, Burgin Alex, Beaudry Amber, Karpeisky Alexander, Matulic Adamic Jasenka, Sweedler David, Zinnen Shawn, WARBURG Richard J, November 4, 1999: WO/1999/055857

Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed.