1
Scot Douglas Hoeksema: Two phase extraction of oil from biomass. Martek Biosciences Corporation, Brebeck Phleger & Harrison, December 26, 2000: US06166231 (171 worldwide citation)

A method of separating edible oil from biological material is disclosed. A biomass slurry containing microbial material in an aqueous suspension is collected. The slurry is typically placed in a centrifuge and then in a homogenizer. The resulting slurry is fed into a contacting device, such as a pac ...


2
Craig M Ruecker, Swithin Patrick Adu peasah, Brian S Engelhardt, George T Veeder III: Solventless extraction process. Martek Biosciences Corporation, Sheridan Ross P C, June 15, 2004: US06750048 (138 worldwide citation)

The present invention provides a method for extracting lipids from microorganisms without using organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microorganisms by lysing cells and removing water soluble compound and/or materi ...


3
David J Kyle, Sue E Reeb, Valerie J Sicotte: Pharmaceutical composition and dietary supplement containing docosarexaenoic acid obtained from dinoflagellates. Martek Biosciences Corporation, Banner & Allegretti, February 20, 1996: US05492938 (136 worldwide citation)

A pharmaceutical composition and a dietary supplement comprising a single cell oil containing at least 20% docosahexaenoic acid (DHA) in triglyceride form are presented. The single cell oil is extracted from biomass produced by cultivating heterotrophic microalgae of the class Dinophyceae in an aero ...


4
Raymond M Gladue, Paul W Behrens: DHA-containing nutritional compositions and methods for their production. Martek Biosciences, Brobeck Phleger & Harrison, April 16, 2002: US06372460 (116 worldwide citation)

This invention provides a particulate material suitable for use as a nutritional supplement, particularly as an aquaculture feed. The particulate material has a high proportion of DHA residues in the lipid fraction, which may be up to 35% of the material, or even more. Preferably, the material has a ...


5
Jaouad Fichtali, Anand Sundararajan: Process for preparing materials for extraction. Martek Biosciences Corporation, Sheridan Ross P C, March 16, 2010: US07678931 (91 worldwide citation)

The present invention relates to a process for preparing a biomass, such as from a microbial fermentation, for an extraction process to separate desired chemicals, nutritional products, bioactive components, proteins, carbohydrates, and lipids, from the biomass. Particularly preferred substances to ...


6
Paul G Roessler, T Dave Matthews, Tom M Ramseier, James G Metz: Product and process for transformation of Thraustochytriales microorganisms. Martek Biosciences Corporation, Sheridan Ross P C, February 21, 2006: US07001772 (89 worldwide citation)

Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, α-tubulin promoter, a promoter from a Thraustochytriales polyketide synthase (PKS) system, and fatty acid desaturase promoter, each from a Thraustochytriales microorganism. Also d ...


7
David John Kyle, Sue Ellen Reeb, Valerie Jacqueline Sicotte: Dinoflagellate biomass, methods for its production, and compositions containing the same. Martek Biosciences Corporation, Baker & Botts L, January 27, 1998: US05711983 (76 worldwide citation)

A biomass is provided which consists essentially of cells of dinoflagellates of the class Dinophyceae which have been cultivated to produce high cell mass and high DHA content. Biomass consisting of cells of Crypthecodinium cohnii is preferred. The cells are cultivated in an aerobic fermentor to ach ...


8
James G Metz, Craig A Weaver, William R Barclay, James H Flatt: PUFA polyketide synthase systems and uses thereof. Martek Biosciences Corporation, Sheridan Ross P C, May 1, 2007: US07211418 (75 worldwide citation)

The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms c ...


9
Craig A Weaver, Ross Zirkle, James G Metz: PUFA polyketide synthase systems and uses thereof. Martek Biosciences Corporation, Sheridan Ross P C, May 15, 2007: US07217856 (72 worldwide citation)

Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding ...


10
James G Metz, James H Flatt, Jerry M Kuner, William R Barclay: PUFA polyketide synthase systems and uses thereof. Martek Biosciences Corporation, Sheridan Ross P C, September 18, 2007: US07271315 (70 worldwide citation)

Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from Schizochytrium, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof tha ...



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