1
Bhat Balkrishen, Carroll Steven S, Eldrup Anne B, Maccoss Malcolm, Olsen David B, Prakash Thazha P: Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase. Merck & Co, Isis Pharmaceuticals, Bhat Balkrishen, Carroll Steven S, Eldrup Anne B, Maccoss Malcolm, Olsen David B, Prakash Thazha P, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, January 22, 2004: WO/2004/007512 (75 worldwide citation)

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are partic ...


2
Olsen David B, Maccoss Malcolm, Bhat Balkrishen, Eldrup Anne B: Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase. Merck & Co, Isis Pharmaceuticals, Olsen David B, Maccoss Malcolm, Bhat Balkrishen, Eldrup Anne B, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, January 8, 2004: WO/2004/003138 (71 worldwide citation)

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are partic ...


3
Maccoss Malcolm, Olsen David B, Leone Joseph, Durette Philippe L: Fluorinated pyrrolo[2,3-d]pyrimidine nucleosides for the treatment of rna-dependent rna viral infection. Merck & Co, Maccoss Malcolm, Olsen David B, Leone Joseph, Durette Philippe L, MERCK 126 East Lincoln Avenue Philippe L Durette Rahway NJ 07065 0907, June 22, 2006: WO/2006/065335 (55 worldwide citation)

The present invention provides fluorinated pyrrolo[2,3,d]pyrimidine nucleoside compounds which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are p ...


4
Maccoss Malcolm, Olsen David B: Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection. Merck & Co, Maccoss Malcolm, Olsen David B, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, February 2, 2006: WO/2006/012078 (55 worldwide citation)

The present invention provides nucleoside aryl phosphoramidates which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They ar ...


5
Butora Gabor, Maccoss Malcolm, Bhat Balkrishen, Eldrup Anne B: C-purine nucleoside analogs as inhibitors of rna-dependent rna viral polymerase. Merck & Co, Isis Pharmaceuticals, Butora Gabor, Maccoss Malcolm, Bhat Balkrishen, Eldrup Anne B, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, December 29, 2005: WO/2005/123087 (53 worldwide citation)

The present invention provides C-purine nucleoside analogs and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are ...


6
Butora Gabor, Guiadeen Deodialsingh, Kothandaraman Shankaran, Maccoss Malcolm, Mills Sander G, Yang Lihu: Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity. Merck & Co, Butora Gabor, Guiadeen Deodialsingh, Kothandaraman Shankaran, Maccoss Malcolm, Mills Sander G, Yang Lihu, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, August 11, 2005: WO/2005/072361 (38 worldwide citation)

Compounds of Formula I and Formula II (wherein A, E, j, k, m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R24, R25, R26, R27, R28, R29, R30, R31, R32, R33, R34, X, Y and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the preven ...


7
Maccoss Malcolm, Olsen David B, Donghi Monica, Gardelli Cristina, Harper Steven, Meppen Malte, Narjes Frank, Pacini Barbara: Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection. Merck & Co, Istituto Di Ricerche Di Biologia Molecolare P Angeletti, Maccoss Malcolm, Olsen David B, Donghi Monica, Gardelli Cristina, Harper Steven, Meppen Malte, Narjes Frank, Pacini Barbara, MERCK 126 East Lincoln Avenue Rahway New Jersey 07065 0907, August 23, 2007: WO/2007/095269 (35 worldwide citation)

The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RN ...


8

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Carroll Steven S, Maccoss Malcolm, Olsen David B, Bhat Balkrishen, Bhat Neelima, Cook Phillip Dan, Eldrup Anne B, Prakash Thazha P, Prhavc Marija, Song Quanlai: Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase. Merck & Co, Isis Pharmaceuticals, Carroll Steven S, Maccoss Malcolm, Olsen David B, Bhat Balkrishen, Bhat Neelima, Cook Phillip Dan, Eldrup Anne B, Prakash Thazha P, Prhavc Marija, Song Quanlai, DURETTE Philippe L, July 25, 2002: WO/2002/057287 (7 worldwide citation)

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are partic ...


10
Sings Heather I, Ujjainwalla Feroze, Maccoss Malcolm, Myers Robert W: 2-azetidinones as anti-hypercholesterolemic agents. Merck & Co, Sings Heather I, Ujjainwalla Feroze, Maccoss Malcolm, Myers Robert W, MERCK 126 East Lincoln Avenue Rahway New Jersey 07065 0907, May 19, 2005: WO/2005/044256 (5 worldwide citation)

The instant invention provides novel cholesterol absorption inhibitors of Formula I and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atheros ...