1
Birnberg Neal C, Liu Hong, Weng Qing Peng, Shang Haibo, Yin Pan, Rajur Sharanappa B, Kim Hwa Ok, Salgaonkar Paresh D, Peet Norton P: Ampk modulators. Mercury Therapeutics, Birnberg Neal C, Liu Hong, Weng Qing Peng, Shang Haibo, Yin Pan, Rajur Sharanappa B, Kim Hwa Ok, Salgaonkar Paresh D, Peet Norton P, ELMORE Carolyn S, August 13, 2009: WO/2009/100130 (38 worldwide citation)

The present invention relates to compounds and pharmaceutically acceptable salts, esters and prodrugs of Formula (I) or (II), which are useful as AMPK modulators effective in treating diabetes, obesity and cancer in a subject.


2
Brady Lowell J, Klucher Kevin M, Chan Chung, Dong Dennis L, Liu Hong Y, Sheppard Paul O, Bukowski Thomas R: Homogeneous preparations of il-28 and il-29. Zymogenetics, Brady Lowell J, Klucher Kevin M, Chan Chung, Dong Dennis L, Liu Hong Y, Sheppard Paul O, Bukowski Thomas R, WALSH Brian J, March 17, 2005: WO/2005/023862 (35 worldwide citation)

Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. O ...


3
Yang Yi Yan, Liu Hong Wei, Ching Chi Bun, Chen Hong: Thermally responsive micelles. Agency For Science Technology And Research, Nanyang Technological University, Yang Yi Yan, Liu Hong Wei, Ching Chi Bun, Chen Hong, ELLA CHEONG SPRUSON PO Box 1531 Robinson Road Post Office Singapore 903031, January 10, 2008: WO/2008/004988 (18 worldwide citation)

The invention provides an amphiphilic copolymer comprising monomer units derived from a first monomer and monomer units derived from a second monomer. The copolymer has at least one hydrophobic endgroup. The first monomer is such that the copolymer is thermally responsive and the second monomer comp ...


4
Liu Hong, He Xiaohui, Choi Ha Soon, Yang Kunyong, Woodmansee David, Wang Zhicheng, Ellis David Archer, Wu Baogen, He Yun, Nguyen Truc Ngoc: Compounds and compositions as inhibitors of cannabinoid receptor 1 activity. Irm, Liu Hong, He Xiaohui, Choi Ha Soon, Yang Kunyong, Woodmansee David, Wang Zhicheng, Ellis David Archer, Wu Baogen, He Yun, Nguyen Truc Ngoc, REID Scott W, May 4, 2006: WO/2006/047516 (17 worldwide citation)

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).


5
Boyle Craig D, Chackalamannil Samuel, Lankin Claire M, Shah Unmesh G, Neustadt Bernard R, Liu Hong, Stamford Andrew W: Pyrimidinone derivatives and methods of use thereof. Schering Corporation, Boyle Craig D, Chackalamannil Samuel, Lankin Claire M, Shah Unmesh G, Neustadt Bernard R, Liu Hong, Stamford Andrew W, BERGMAN Jeffrey P, October 30, 2008: WO/2008/130584 (13 worldwide citation)

The present invention relates to Pyrimidinone Derivatives, compositions comprising a Pyrimidinone Derivative, and methods of using the Pyrimidinone Derivatives for treating or preventing obesity, diabetes, a metabolic disease, a cardiovascular disease or a disorder related to the activity of GPR119 ...


6
Xia Yan, Boyle Craig D, Greenlee William J, Chackalamannil Samuel, Jayne Charles Lee, Stamford Andrew W, Dai Xing, Harris Joel M, Neustadt Bernard R, Neelamkavil Santhosh Francis, Shah Unmesh G, Lankin Claire M, Liu Hong: Bicyclic heterocycle derivatives and methods of use thereof. Schering Corporation, Xia Yan, Boyle Craig D, Greenlee William J, Chackalamannil Samuel, Jayne Charles Lee, Stamford Andrew W, Dai Xing, Harris Joel M, Neustadt Bernard R, Neelamkavil Santhosh Francis, Shah Unmesh G, Lankin Claire M, Liu Hong, BERGMAN Jeffrey P, April 30, 2009: WO/2009/055331 (12 worldwide citation)

The present invention relates to Bicyclic Heterocycle Derivatives, compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related t ...


7
Neustadt Bernard R, Hao Jinsong, Liu Hong, Boyle Craig D, Chackalamannil Samuel, Shah Unmesh G, Stamford Andrew, Harris Joel M: Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine a2a receptor antagonists. Schering Corporation, Neustadt Bernard R, Hao Jinsong, Liu Hong, Boyle Craig D, Chackalamannil Samuel, Shah Unmesh G, Stamford Andrew, Harris Joel M, MAGATTI Anita W, November 3, 2005: WO/2005/103055 (11 worldwide citation)

Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, furanyl, thienyl, pyridyl, pyridyl N-oxide, oxazolyl or pyrrolyl, or cycloalkenyl R1, R2, R3, R4 and R5 are H, alkyl or alkoxyalkyl; and Z is optionally substituted ar ...


8
ADER Daniel, FINNESSY John J, LI Zhaolong, LIU Hong, MASUCCI James Daniel, SHAH Ronak Hasmukh, TAO Nengbing, WANG Dafu: [fr] PROCÉDÉS ET COMPOSITIONS DE LUTTE CONTRE LES MAUVAISES HERBES, [en] METHODS AND COMPOSITIONS FOR WEED CONTROL. ADER Daniel, FINNESSY John J, LI Zhaolong, LIU Hong, MASUCCI James Daniel, SHAH Ronak Hasmukh, TAO Nengbing, WANG Dafu, MONSANTO TECHNOLOGY, MCBRIDE Thomas P, March 21, 2013: WO/2013/040057 (10 worldwide citation)

[en] Provided are novel compositions for use to enhance weed control. Specifically, methods and compositions that modulate Phytoene desaturase in weed species are disclosed. Combinations are presented of compositions and methods that enhance weed control.


9
Liu Hong, He Xiaohui, Phillips Dean, Zhu Xuefeng, Yang Kunyong, Lau Thomas, Wu Baogen, Xie Yongping, Nguyen Truc Ngoc, Wang Xing: Compounds and compositions as inhibitors of cannabinoid receptor 1 activity. Irm, Liu Hong, He Xiaohui, Phillips Dean, Zhu Xuefeng, Yang Kunyong, Lau Thomas, Wu Baogen, Xie Yongping, Nguyen Truc Ngoc, Wang Xing, REID Scott W, June 26, 2008: WO/2008/076754 (9 worldwide citation)

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).


10
NEUSTADT Bernard R, LIU Hong: Dérivés hétérocycles bicycliques et procédés dutilisation de ceux-ci, Bicyclic heterocycle derivatives and methods of use thereof. Merck Sharp & Dohme, NEUSTADT Bernard R, LIU Hong, December 22, 2011: WO/2011/159657 (7 worldwide citation)

Compounds of structural formula I: are GPR119 agonists and are useful for the treatment, control or prevention of disorders responsive to agonism of GPR119, such as metabolic-related disorders such as type I diabetes, type II diabetes, inadequate glucose tolerance, insulin resistance, hyperglycemia, ...