1
Hanai Nobuo, Nakamura Kazuyasu, Shoji Emi, Yamasaki Motoo, Uchida Kazuhisa, Shinkawa Toyohide, Imabeppu Susumu, Kanda Yutaka, Yamane Naoko, Anazawa Hideharu: Method for controlling the activity of immunologically functional molecule. Kyowa Hakko Kogyo, January 30, 2002: EP1176195-A1 (254 worldwide citation)

The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promote ...


2
Nakagawa Satochi, Mizoguchi Hiroshi, Ando Seiko, Hayashi Mikiro, Ochiai Keiko, Yokoi Haruhiko, Tateishi Naoko, Senoh Akihiro, Ikeda Masato, Ozaki Akio: Novel polynucleotides. Kyowa Hakko Kogyo, June 20, 2001: EP1108790-A2 (180 worldwide citation)

Novel polynucleotides derived from microorganisms belonging to coryneform bacteria and fragments thereof, polypeptides encoded by the polynucleotides and fragments thereof, polynucleotide arrays comprising the polynucleotides and fragments thereof, recording media in which the nucleotide sequences o ...


3
Sasaki Katsutoshi, Nishi Tatsunari, Yasumura Shigeyoshi, Sato Moriyuki, Itoh Seiga: Glycosylated polypeptides.. Kyowa Hakko Kogyo, May 30, 1990: EP0370205-A2 (121 worldwide citation)

A polypeptide or glycosylated polypeptide with at least one new carbohydrate chain produced by means of recombinant DNA technique, which has protease resistance and thermal stability and is expected to have longer lifetime in blood than those of a naturally-occurring form.


4
Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai: Cells producing antibody compositions with increased antibody dependent cytotoxic activity. Kyowa Hakko Kogyo, Nixon & Vanderhye P C, September 20, 2005: US06946292 (120 worldwide citation)

The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a meth ...


5
Takekoshi Yoichiro, Takahashi Tomoya, Onuma Toshio: Cosmetic. Kyowa Hakko Kogyo, March 19, 2002: JP2002-080321 (99 worldwide citation)

PROBLEM TO BE SOLVED: To provide a cosmetic having skin-aging retarding action and skin- quality improving action in addition to moisturizing function.SOLUTION: This cosmetic is obtained by including (1) hydroxyproline, an N-acylated derivative thereof or a salt thereof and (2) one ingredient select ...


6
Chikara Murakata, Akira Sato, Mitsuru Takahashi, Eiji Kobayashi, Makoto Morimoto, Shiro Akinaga, Tadashi Hirata, Kenichi Mochida, Hiroshi Kase, Koji Yamada, Kazuyuki Iwashashi: Derivatives of physiologically active substance K-252. Kyowa Hakko Kogyo, Michael N Meller, May 8, 1990: US04923986 (83 worldwide citation)

The present invention relates to novel derivatives of K-252, (8R*, 9S*, 11S*)-(-)-9-hydroxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8,11-ep oxy-1H,8H, 11H-2,7b,11a-triazadibenzo[a,g]cycloocta-[c,d,e,]trinden-1-one, and the compounds are represented by formula (I): ##STR1## wherein W.sub.1, W. ...


7
Yamasaki Motoo, Yokoo Yoshiharu, Morimoto Makoto, Okabe Masami: Modified human g-csf.. Kyowa Hakko Kogyo, October 4, 1989: EP0335423-A2 (79 worldwide citation)

A modified polypeptide having human granulocyte colony stimulating factor (hG-CSF) activity comprising a polypeptide having hG-CSF activity with at least one amino group thereof substituted with a group of the formula R1 @OCH2CH2 @nX-R2- (I) wherein R1 is an alkyl or alkanoyl group; n is an optional ...


8
Katsutoshi Sasaki, Tatsunari Nishi, Shigeyoshi Yasumura, Moriyuki Sato, Seiga Itoh: Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains. Kyowa Hakko Kogyo, Nixon & Vanderhye, June 8, 1993: US05218092 (77 worldwide citation)

A polypeptide or glycosylated polypeptide with at least one new carbohydrate chain produced by means of recombinant DNA technique, which has protease resistance and thermal stability and is expected to have longer lifetime in blood than those of a naturally-occurring form.


9
Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa: Method of modulating the activity of functional immune molecules. Kyowa Hakko Kogyo, Nixon & Vanderhye P C, May 8, 2007: US07214775 (76 worldwide citation)

The invention relates to a method for controlling the activity of an immunologically functional molecules, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having promoted a ...


10
Kenya Shitara, Nobuo Hanai, Mamoru Hasegawa, Hiromasa Miyaji, Yoshihisa Kuwana: Process for producing humanized chimera antibody. Kyowa Hakko Kogyo, Nixon & Vanderhye P C, February 2, 1999: US05866692 (75 worldwide citation)

A humanized chimera antibody, a pharmaceutical composition comprising a humanized chimera antibody and a pharmaceutically acceptable carrier, and a method of treating cancer which comprises administering to a patient a pharmaceutically acceptable amount of said humanized chimera antibody, are disclo ...