1
Kono Yasushi, Andou Naoki, Sawada Takayuki, Kuriyama Kazuhiko, Iwanami Satoru: 2-amino-1,3-propanediol derivative and its addition salt. Kyorin Pharmaceut, November 4, 2004: JP2004-307440 (24 worldwide citation)

PROBLEM TO BE SOLVED: To provide a 2-amino-1,3-propanediol derivative having excellent immunosuppression action and having few side effects.SOLUTION: The aminodiol derivative is represented by general formula (1) and a concrete example thereof is 2-amino-2-[3-[4-(benzothiazol-2-ylamino)phenyl]propyl ...


2
Kono Yasushi, Tanase Takahiro, Andou Naoki, Kuriyama Kazuhiko: Heterocyclic derivative, its addition salt and immunosuppressant. Kyorin Pharmaceut, November 4, 2004: JP2004-307442 (15 worldwide citation)

PROBLEM TO BE SOLVED: To provide a heterocyclic derivative having excellent immunosuppression action and having few side effects.SOLUTION: The heterocyclic derivative is an aminoalcohol derivative represented by general formula (1) and a concrete example thereof is 2-amino-2-[3-[6-(3-benzyloxyphenox ...


3
Seto Shigeki, Tanioka Asao, Ikeda Makoto, Izawa Shigeru: Condensed bicyclic pyridine derivative. Kyorin Pharmaceut, October 2, 2003: JP2003-277384 (14 worldwide citation)

PROBLEM TO BE SOLVED: To provide a new condensed bicyclic pyridine derivative having a tachykinin receptor antagonist, particularly NK1 receptor antagonist.SOLUTION: The present invention provides the condensed bicyclic pyridine derivative represented by general formula (1) [wherein a ring A and a r ...


4
Aono Masahiro, Tanioka Asao, Ikeda Makoto, Izawa Shigeru: Fused biphenyl derivative. Kyorin Pharmaceut, November 11, 2003: JP2003-321461 (13 worldwide citation)

PROBLEM TO BE SOLVED: To obtain a new fused biphenyl derivative having tachykinin receptor antagonism, especially NK1 receptor antagonism.SOLUTION: The fused biphenyl derivative is expressed by general formula (1) (wherein A ring and B ring express each a benzene ring which may have 1-3 substituents ...


5
Tsubuki Takeshi, Nomura Masahiro, Sawada Takayuki, Kono Yasushi, Sekoe Yasuhiko: 2-substituted benzothiazole derivative and its production. Kyorin Pharmaceut, March 28, 2000: JP2000-086641 (12 worldwide citation)

PROBLEM TO BE SOLVED: To obtain the subject new compound capable of inhibiting the bond between leukocyte and ICAM-I playing a central role among cell adhesion molecules and useful as e.g. an excellent immunosuppressive agent. SOLUTION: This compound is expressed by formula I [R1 is H or a 1-4C alky ...


6
Kono Yasushi, Andou Naoki, Sawada Takayuki, Kuriyama Kazuhiko: Aminodiol derivative, its addition salt and immunosuppressant. Kyorin Pharmaceut, November 4, 2004: JP2004-307439 (9 worldwide citation)

PROBLEM TO BE SOLVED: To provide an aminodiol derivative having excellent immunosuppression action and having few side effects.SOLUTION: The aminodiol derivative is represented by general formula (1) and a concrete example thereof is 2-amino-2-[3-[4-(3-trifluoromethylbenzyloxy)phenyl]propyl]propane- ...


7
Kono Yasushi, Andou Naoki, Kuriyama Kazuhiko: Benzene derivative, its addition salt and immunosuppressant. Kyorin Pharmaceut, November 4, 2004: JP2004-307441 (8 worldwide citation)

PROBLEM TO BE SOLVED: To provide a benzene derivative having excellent immunosuppression action and having few side effects.SOLUTION: The benzene derivative is represented by general formula (1) and a concrete example thereof is 2-amino-2-[3-[4-(5-benzyloxybenzothiazol-2-ylsulfanyl)-2-chlorophenyl]p ...


8
Takano Yasuo, Shiga Futoshi, Anraku Takeshi, Asano Jun: 6,7-disubstituted carboxylic acid derivative and its addition salt and their production. Kyorin Pharmaceut, June 20, 2000: JP2000-169451 (8 worldwide citation)

PROBLEM TO BE SOLVED: To obtain a new 6,7-disubstituted carboxylic acid derivative having a glutamic acid receptor antagonisin, especially having high affinity and selectivity against the AMPA receptor of non-NMDA receptor, and capable of exhibiting a cerebral nerve cell-protecting effect.SOLUTION: ...


9
Kono Yasushi, Ochiai Koji, Takita Tetsushi, Kojima Akihiko, Eiraku Tomohiko, Kishi Tetsuya: Carbostyril derivative and pde inhibitor comprising the same as active ingredient. Kyorin Pharmaceut, February 26, 2009: JP2009-040711 (7 worldwide citation)

PROBLEM TO BE SOLVED: To provide a new carbostyril derivative useful as a medicine having PDE (phosphodiesterase) inhibitory actions.SOLUTION: The carbostyril derivative is represented by general formula (1).


10
Kono Yasushi, Andou Naoki, Sawada Takayuki, Kudo Shinji, Kuriyama Kazuhiko, Iwanami Satoru: Alkenylamino acid derivative and method for manufacturing the same. Kyorin Pharmaceut, May 22, 2002: JP2002-145848 (6 worldwide citation)

PROBLEM TO BE SOLVED: To provide a new proteasome-inhibiting substance, and thereby to provide an excellent immunosuppressant, antiinflammatory agent, antiallergic agent, treating agent for an autoimmune disease, antitumor agent and treating agent for a neurodegenerative disease.SOLUTION: A new alke ...