1

Kono Yasushi, Andou Naoki, Sawada Takayuki, Kuriyama Kazuhiko, Iwanami Satoru:
2-amino-1,3-propanediol derivative and its addition salt.
Kyorin Pharmaceut,
November 4, 2004:
JP2004-307440
(24 worldwide citation)

PROBLEM TO BE SOLVED: To provide a 2-amino-1,3-propanediol derivative having excellent immunosuppression action and having few side effects.SOLUTION: The aminodiol derivative is represented by general formula (1) and a concrete example thereof is 2-amino-2-[3-[4-(benzothiazol-2-ylamino)phenyl]propyl ...

2

Kono Yasushi, Tanase Takahiro, Andou Naoki, Kuriyama Kazuhiko:
Heterocyclic derivative, its addition salt and immunosuppressant.
Kyorin Pharmaceut,
November 4, 2004:
JP2004-307442
(15 worldwide citation)

PROBLEM TO BE SOLVED: To provide a heterocyclic derivative having excellent immunosuppression action and having few side effects.SOLUTION: The heterocyclic derivative is an aminoalcohol derivative represented by general formula (1) and a concrete example thereof is 2-amino-2-[3-[6-(3-benzyloxyphenox ...

3

Seto Shigeki, Tanioka Asao, Ikeda Makoto, Izawa Shigeru:
Condensed bicyclic pyridine derivative.
Kyorin Pharmaceut,
October 2, 2003:
JP2003-277384
(14 worldwide citation)

PROBLEM TO BE SOLVED: To provide a new condensed bicyclic pyridine derivative having a tachykinin receptor antagonist, particularly NK1 receptor antagonist.SOLUTION: The present invention provides the condensed bicyclic pyridine derivative represented by general formula (1) [wherein a ring A and a r ...

4

Aono Masahiro, Tanioka Asao, Ikeda Makoto, Izawa Shigeru:
Fused biphenyl derivative.
Kyorin Pharmaceut,
November 11, 2003:
JP2003-321461
(13 worldwide citation)

PROBLEM TO BE SOLVED: To obtain a new fused biphenyl derivative having tachykinin receptor antagonism, especially NK1 receptor antagonism.SOLUTION: The fused biphenyl derivative is expressed by general formula (1) (wherein A ring and B ring express each a benzene ring which may have 1-3 substituents ...

5

Tsubuki Takeshi, Nomura Masahiro, Sawada Takayuki, Kono Yasushi, Sekoe Yasuhiko:
2-substituted benzothiazole derivative and its production.
Kyorin Pharmaceut,
March 28, 2000:
JP2000-086641
(12 worldwide citation)

PROBLEM TO BE SOLVED: To obtain the subject new compound capable of inhibiting the bond between leukocyte and ICAM-I playing a central role among cell adhesion molecules and useful as e.g. an excellent immunosuppressive agent. SOLUTION: This compound is expressed by formula I [R1 is H or a 1-4C alky ...

6

Kono Yasushi, Andou Naoki, Sawada Takayuki, Kuriyama Kazuhiko:
Aminodiol derivative, its addition salt and immunosuppressant.
Kyorin Pharmaceut,
November 4, 2004:
JP2004-307439
(9 worldwide citation)

PROBLEM TO BE SOLVED: To provide an aminodiol derivative having excellent immunosuppression action and having few side effects.SOLUTION: The aminodiol derivative is represented by general formula (1) and a concrete example thereof is 2-amino-2-[3-[4-(3-trifluoromethylbenzyloxy)phenyl]propyl]propane- ...

7

Kono Yasushi, Andou Naoki, Kuriyama Kazuhiko:
Benzene derivative, its addition salt and immunosuppressant.
Kyorin Pharmaceut,
November 4, 2004:
JP2004-307441
(8 worldwide citation)

PROBLEM TO BE SOLVED: To provide a benzene derivative having excellent immunosuppression action and having few side effects.SOLUTION: The benzene derivative is represented by general formula (1) and a concrete example thereof is 2-amino-2-[3-[4-(5-benzyloxybenzothiazol-2-ylsulfanyl)-2-chlorophenyl]p ...

8

Takano Yasuo, Shiga Futoshi, Anraku Takeshi, Asano Jun:
6,7-disubstituted carboxylic acid derivative and its addition salt and their production.
Kyorin Pharmaceut,
June 20, 2000:
JP2000-169451
(8 worldwide citation)

PROBLEM TO BE SOLVED: To obtain a new 6,7-disubstituted carboxylic acid derivative having a glutamic acid receptor antagonisin, especially having high affinity and selectivity against the AMPA receptor of non-NMDA receptor, and capable of exhibiting a cerebral nerve cell-protecting effect.SOLUTION: ...

9

Kono Yasushi, Ochiai Koji, Takita Tetsushi, Kojima Akihiko, Eiraku Tomohiko, Kishi Tetsuya:
Carbostyril derivative and pde inhibitor comprising the same as active ingredient.
Kyorin Pharmaceut,
February 26, 2009:
JP2009-040711
(7 worldwide citation)

PROBLEM TO BE SOLVED: To provide a new carbostyril derivative useful as a medicine having PDE (phosphodiesterase) inhibitory actions.SOLUTION: The carbostyril derivative is represented by general formula (1).

10

Kono Yasushi, Andou Naoki, Sawada Takayuki, Kudo Shinji, Kuriyama Kazuhiko, Iwanami Satoru:
Alkenylamino acid derivative and method for manufacturing the same.
Kyorin Pharmaceut,
May 22, 2002:
JP2002-145848
(6 worldwide citation)

PROBLEM TO BE SOLVED: To provide a new proteasome-inhibiting substance, and thereby to provide an excellent immunosuppressant, antiinflammatory agent, antiallergic agent, treating agent for an autoimmune disease, antitumor agent and treating agent for a neurodegenerative disease.SOLUTION: A new alke ...