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BRADLEY Allan, LEE E Chiang, LIANG Qi, WANG Wei: Modèles animaux et molécules thérapeutiques, Animal models and therapeutic molecules. Kymab, BRADLEY Allan, LEE E Chiang, LIANG Qi, WANG Wei, STEPHEN Robert, December 22, 2011: WO/2011/158009 (54 worldwide citation)

The invention discloses methods for the generation of chimaeric human - non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivativ ...


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BRADLEY Allan, FRIEDRICH Glenn, LEE E Chiang, STRIVENS Mark, ENGLAND Nicholas: [fr] ANTICORPS, DOMAINES VARIABLES & CHAÎNES ADAPTÉES POUR UNE UTILISATION HUMAINE, [en] ANTIBODIES, VARIABLE DOMAINS & CHAINS TAILORED FOR HUMAN USE. BRADLEY Allan, FRIEDRICH Glenn, LEE E Chiang, STRIVENS Mark, ENGLAND Nicholas, KYMAB, STEPHEN Robert, March 28, 2013: WO/2013/041844 (41 worldwide citation)

[en] The invention relates to the provision of antibody therapeutics and prophylactics that are tailored specifically for human use. The present invention provides libraries, vertebrates and cells, such as transgenic mice or rats or transgenic mouse or rat cells. Furthermore, the invention relates t ...


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BRADLEY Allan, LEE E Chiang, LIANG Qi, WANG Wei, LEGENT Anais, KIRBY Ian, SPENSBERGER Dominik, LIU Hui, FRIEDRICH Glenn A: [fr] COMMUTATION ISOTYPIQUE FONCTIONNELLE DE CHAÎNES DANTICORPS CHIMÈRES ET ANIMAUX CHIMÈRES EXPRIMANT DIFFÉRENTS ISOTYPES IGH, [en] FUNCTIONAL ISOTYPE SWITCHING OF CHIMAERIC ANTIBODY CHAINS & CHIMAERIC ANIMALS EXPRESSING DIFFERENT IGH ISOTYPES. KYMAB, STEPHEN Robert, May 2, 2013: WO/2013/061098 (18 worldwide citation)

[en] The invention discloses methods for the generation of chimaeric humannon-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivat ...


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BRADLEY Alan, LEE E Chiang: [fr] ANIMAUX, RÉPERTOIRES & PROCÉDÉS, [en] ANIMALS, REPERTOIRES & METHODS FOR THE PRODUCTION OF HUMAN ANTIBODIES. BRADLEY Alan, LEE E Chiang, KYMAB, STEPHEN Robert, March 28, 2013: WO/2013/041845 (18 worldwide citation)

[en] The present invention is directed to the concept of sectoring antibody gene segment repertoires in order to enable the development of novel, synthetic antibody chain repertoires not seen in nature. The present invention is also directed to the realisation of the inventors that sectoring can als ...


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BRADLEY ALLAN, LEE E CHIANG, LIANG QI, WANG WEI: Modèles animaux et molécules thérapeutiques, Tiermodelle und therapeutische Moleküle, Animal models and therapeutic molecules. KYMAB, October 31, 2012: EP2517557-A2 (13 worldwide citation)

The invention discloses methods for the generation of chimaeric human - non human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies compositions comprising said antibodies, antibody chains and derivative ...


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Allan Bradley, E Chiang Lee, Qi Liang, Wei Wang, Dominik Spensberger, Hui Liu, Jasper Clube: Animal models and therapeutic molecules. Kymab, Sunstein Kann Murphy & Timbers, February 9, 2016: US09253965 (11 worldwide citation)

The invention discloses methods for the generation of chimaeric human-nonhuman antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising the disclosed antibodies, antibody chains and der ...


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BRADLEY ALLAN, LEE E CHIANG, LIANG QI, WANG WEI: [fr] Modèles animaux et molécules thérapeutiques, [de] Tiermodelle und therapeutische Moleküle, [en] Animal models and therapeutic molecules. KYMAB, March 6, 2013: EP2564695-A1 (11 worldwide citation)

[en] The invention discloses methods for the generation of chimaeric human - non human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies compositions comprising said antibodies, antibody chains and deriv ...


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BRADLEY ALLAN, LEE E CHIANG, LIANG QI, WANG WEI: Modèles animaux et molécules thérapeutiques, Tiermodelle und therapeutische Moleküle, Animal models and therapeutic molecules. KYMAB, October 31, 2012: EP2517556-A2 (11 worldwide citation)

The invention discloses methods for the generation of chimaeric human - non human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies compositions comprising said antibodies, antibody chains and derivative ...


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