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Zupancic Silvo, Skrabanja Vida: Process for preparation of o-desmethylvenlafaxine and its analogue. Krka D D Novo Mesto, December 26, 2007: EP1870395-A1 (38 worldwide citation)

The present invention belongs to the field of organic chemistry and refers to a process for the preparation of O -desmethylvenlafaxine (1-[2-Dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol) and its analogues. The invention also relates to a catalytic hydrogenation of cyano-group of the substitu ...


2
BOSE PROSENJIT: Process for preparation of ivabradine. KRKA D D NOVO MESTO, Westendorp, Sommer, July 1, 2010: WO/2010/072409 (7 worldwide citation)

The present invention describes a new process for optical resolution of [N-[[3,4- dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]-N-methylamine] which is an intermediate in the preparation of ivabradine.


3
Kramer Andrejka, Pisek Robert, Rajer Tadeja: Sustained release pharmaceutical composition of tolterodine. Krka D D Novo Mesto, March 1, 2006: EP1629834-A1 (3 worldwide citation)

The present invention is directed to a sustained release pharmaceutical composition comprising tolterodine, preferably tolterodine tartrate, to the use of said composition for the preparation of a medicament and to a method for producing such a sustained release pharmaceutical composition.


4
KUKEC SIMON: Pharmaceutical compositions comprising prasugrel base or its pharmaceutically acceptable acid addition salts and processes for their preparation. KRKA D D NOVO MESTO, Westendorp, Sommer, August 26, 2010: WO/2010/094471 (3 worldwide citation)

The subject of the invention includes a pharmaceutical composition comprising prasugrel or its pharmaceutically acceptable salts as the active pharmaceutical ingredient, prepared in the absence of water and characterized in that they do not contain lactose or mannitol.


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Vesna Kroselj, Lakse Renata, Toporisic Rebeka, Kastelic Joze: Pharmaceutical composition comprising simvastatin and ezetimibe. Krka D D Novo Mesto, January 10, 2007: EP1741427-A1 (2 worldwide citation)

The present invention relates to the field of pharmaceutical technology and in particular to novel dosage forms of medicaments containing as active ingredients simvastatin and ezetimibe, or pharmaceutically acceptable salts thereof. The present pharmaceutical compositions are characterized in that t ...


7
SEDMAK Gregor, KROSELJ Vesna, SKUBE Maja Kincl, JURSIC Urska: FORMES PHARMACEUTIQUES ORALES HOMOGÈNES COMPRENANT DE LA LERCANIDIPINE ET DE LÉNALAPRIL OU LEURS SELS PHARMACEUTIQUEMENT ACCEPTABLES, HOMOGENOUS PHARMACEUTICAL ORAL DOSAGE FORMS COMPRISING LERCANIDIPINE AND ENALAPRIL OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS. KRKA D D NOVO MESTO, SEDMAK Gregor, KROSELJ Vesna, SKUBE Maja Kincl, JURSIC Urska, UEXKÜLL & STOLBERG, June 28, 2012: WO/2012/085249 (2 worldwide citation)

The invention relates to pharmaceutical oral dosage forms of the active substances lercanidipine and enalapril, as well the pharmacologically acceptable salts thereof, characterized in that the pharmaceutical oral dosage forms comprise an organic acid to stabilize both enalapril and lercanidipine, a ...


8
VRECER FRANC, PISEK ROBERT, PRESKAR MAJA, KAPELE TOMAZ: [fr] Composition pharmaceutique multi-particules à libération prolongée comportant de la palipéridone, [de] Verlängerte Freisetzung von einer pharmazeutischen Mehrteilchenzusammensetzung mit Paliperidon, [en] Prolonged release multiparticulate pharmaceutical composition comprising paliperidone. KRKA D D NOVO MESTO, March 10, 2010: EP2161019-A1 (1 worldwide citation)

[en] The present application pertains to pharmaceutical compositions comprising paliperidone or a pharmaceutically acceptable salt thereof as the active substance, wherein the pharmaceutical composition is in the form of pellets comprising a core particle, optionally one or more intermediate coating ...


9
Zupancic Silvo, Pecavar Anica, Zupet Rok: A process for the synthesis of valsartan. Krka D D Novo Mesto, May 31, 2006: EP1661891-A1 (1 worldwide citation)

This invention relates to an improved process for preparing a valsartan, or a pharmaceutically acceptable salt thereof, or pharmaceutical preparation containing either entity wherein a compound of formula (II) or a salt thereof, is reacted with valine or an ester or a salt thereof in a solvent selec ...


10
Vrbinc Miha, Slanc Janika, Rangus Marija, Zupancic Silvo, Bevec Franci: Solid pharmaceutical composition comprising valsartan. Krka D D Novo Mesto, June 28, 2006: EP1674080-A1 (1 worldwide citation)

This invention relates to a solid pharmaceutical composition containing valsartan particles characterized in that the D 50 of said valsartan particles is 150 m or below and that the valsartan particles have a maximum diameter of no more than 1100 m, as determined by electron microscopy.



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