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Leamon Christopher Paul, Wang Yu, Vlahov Iontcho Radoslavov, You Fei, Kleindl Paul Joseph, Santhapuram Hari Krishna R: Conjugates containing hydrophilic spacer linkers. Endocyte, Leamon Christopher Paul, Wang Yu, Vlahov Iontcho Radoslavov, You Fei, Kleindl Paul Joseph, Santhapuram Hari Krishna R, BALL Rebecca L, December 31, 2008: WO/2009/002993 (38 worldwide citation)

Described herein are compositions and methods for use in targeted drug delivery using cell- surface receptor binding drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations.


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VLAHOV Iontcho Radoslavov, GROANING Michael, KLEINDL Paul Joseph, SANTHAPURAM Hari Krishna R, YOU Fei, WANG Yu, XU Le cun, STANFORD Katheryn Marie, RITTER Allen, LEAMON Christopher Paul: Procédés de préparation de tubulysines, Processes for preparing tubulysins. Endocyte, VLAHOV Iontcho Radoslavov, GROANING Michael, KLEINDL Paul Joseph, SANTHAPURAM Hari Krishna R, YOU Fei, WANG Yu, XU Le cun, STANFORD Katheryn Marie, RITTER Allen, LEAMON Christopher Paul, BALL Rebecca L, February 9, 2012: WO/2012/019123 (8 worldwide citation)

Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.