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Kesteleyn Bart Rudolf Romanie, Raboisson Pierre Jean Marie, Van de, Vreken Wim, Canard Maxime Francis Jean Marie Ghislain: 1, 5, 6-substituted-2-oxo-3-cyano-1, 6a-diaza-tetrahydro-fluoranthenes as anti-infective agents. Tibotec Pharmaceuticals, Kesteleyn Bart Rudolf Romanie, Raboisson Pierre Jean Marie, Van de, Vreken Wim, Canard Maxime Francis Jean Marie Ghislain, WANTE Dirk, July 13, 2006: WO/2006/072636 (1 worldwide citation)

HIV inhibitory compounds of formula: (I) salts and stereoiso mers thereof, wherein R1 and R2 are hydrogen or optionally substituted C1-10alkyl; R3 is: (a) n is 1, 2 or 3; R3a is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxycarbonyl, aminocarbonyl, C1-4alkyloxycarbonyl, mono- or di(C1-4al ...


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Kesteleyn Bart Rudolf Romanie, Surleraux Dominique Louis Nestor Ghislain, Quaedflieg Peter Jan Leonard Mario: Method for the preparation of hexahydro-furo[2,3-b]furan-3-ol. Tibotec Pharmaceuticals, Kesteleyn Bart Rudolf Romanie, Surleraux Dominique Louis Nestor Ghislain, Quaedflieg Peter Jan Leonard Mario, DAELEMANS Frank, March 20, 2003: WO/2003/022853

The present invention relates to a method for the preparation of hexahydro-furo[2,3-b]furan-3-ol as well as novel intermediates for use in said method. More in particular the invention relates to a stereoselective method for the preparation of hexahydro-furo[2,3-b]furan-3-ol, and to a method amenabl ...


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Schepens Wim Bert Griet, Kesteleyn Bart Rudolf Romanie: Process for preparing 2-oxo-2,5-dihydro-1h-pyrido[3,2-b]indole-3-carbonitriles. Tibotec Pharmaceuticals, Schepens Wim Bert Griet, Kesteleyn Bart Rudolf Romanie, WANTE Dirk, April 3, 2008: WO/2008/037783

A process for preparing 2-oxo-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitriles starting from 1-substituted indole-2-carboxaldehyde with an aromatic amine and reacting the thus obtained intermediate with a cyanoacetic acid ester.