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Kevin Rodzinak
Armstrong Donna J, Hu Essa H, Kelly Michael J Iii, Layton Mark E, Li Yiwei, Liang Jun, Rodzinak Kevin J, Rossi Michael A, Sanderson Philip E, Wang Jiabing: Inhibitors of akt activity. Merck & Co, Armstrong Donna J, Hu Essa H, Kelly Michael J Iii, Layton Mark E, Li Yiwei, Liang Jun, Rodzinak Kevin J, Rossi Michael A, Sanderson Philip E, Wang Jiabing, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, December 21, 2006: WO/2006/135627 (19 worldwide citation)

The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt ...


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Kevin Rodzinak
Layton Mark E, Rodzinak Kevin J, Kelly Michael J Iii, Sanderson Philip E: N-alkyl-azacycloalkyl nmda/nr2b antagonists. Merck & Co, Layton Mark E, Rodzinak Kevin J, Kelly Michael J Iii, Sanderson Philip E, MERCK 126 East Lincoln Avenue Rahway New Jersey 07065 0907, October 26, 2006: WO/2006/113471 (5 worldwide citation)

Compounds represented by Formula (I): and/or pharmaceutically acceptable salts, individual enantiomers and stereoisomers thereof, are effective as NMDA/NR2B antagonists useful for treating conditions such as pain, Parkinson’s disease, Alzheimer’s disease, epilepsy, depression, anxiety, ischemic brai ...


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Kevin Rodzinak
Layton Mark E, Rodzinak Kevin J, Kelly Michael J Iii, Sanderson Philip E: 1,3-disubstituted heteroaryl nmda/nr2b antagonists. Merck & Co, Layton Mark E, Rodzinak Kevin J, Kelly Michael J Iii, Sanderson Philip E, MERCK 126 East Lincoln Avenue Rahway New Jersey 07065 0907, February 16, 2006: WO/2006/017409 (2 worldwide citation)

Compounds represented by Formula I: (wherein A, B, D, P, Q, R1, R2, R3, W and Y are described herein) or pharmaceutically acceptable salts thereof, are effective as NMDA/NR2B antagonists useful for treating neurological conditions such as, for example, pain, Parkinson’s disease, Alzheimer’s disease, ...


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BUNDA Jaime L, COX Christopher D, DUDKIN Vadim Y, FIJI Hannah D, KELLY Michael J III, LAYTON Mark E, PERO Joseph E, SHIPE William D, STEEN Justin T: COMPOSÉS DISOINDOLINONE UTILES COMME INHIBITEURS DE PDE 10, ISOINDOLINONE PDE10 INHIBITORS. MERCK SHARP & DOHME, BUNDA Jaime L, COX Christopher D, DUDKIN Vadim Y, FIJI Hannah D, KELLY Michael J III, LAYTON Mark E, PERO Joseph E, SHIPE William D, STEEN Justin T, May 3, 2012: WO/2012/058133 (6 worldwide citation)

The present invention is directed to isoindolinone compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychi ...


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Kelly Michael J Iii, Layton Mark E, Sanderson Philip E: Inhibitors of akt activity. Merck & Co, Kelly Michael J Iii, Layton Mark E, Sanderson Philip E, MERCK 126 East Lincoln Avenue Rahway New Jersey 07065 0907, June 12, 2008: WO/2008/070041 (1 worldwide citation)

The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt ...


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FIJI Hannah D, KELLY Michael J III, KERN Jeffrey C, LAYTON Mark E, PERO Joseph E, REIF Alexander J, ROSSI Michael A: DÉRIVÉS DIMIDAZOPYRIDIN-2-ONE, IMIDAZOPYRIDIN-2-ONE DERIVATIVES. MERCK SHARP & DOHME, FIJI Hannah D, KELLY Michael J III, KERN Jeffrey C, LAYTON Mark E, PERO Joseph E, REIF Alexander J, ROSSI Michael A, December 20, 2012: WO/2012/174199 (1 worldwide citation)

The present invention is directed to imidazopyridin-2-one derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and ...