1
Goutopoulos Andreas, Askew Jr Benny C, Diep Nhut Kiet, Karra Srinivasa, Schwarz Matthias, Yu Henry: Novel arylamino n-heteraryls as mek inhibitors. Laboratoires Serono, Goutopoulos Andreas, Askew Jr Benny C, Diep Nhut Kiet, Karra Srinivasa, Schwarz Matthias, Yu Henry, DAVIS Steven G, November 1, 2007: WO/2007/123939 (10 worldwide citation)

The invention provides novel arylamino N-heteroaryl MEK inhibitors of Formula (I): Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed. is the treatment of a hyperproliferative disease in mammals, and phar ...


2
Araldi Gian Luca, Karra Srinivasa, Reddy Adulla P, Liao Yihua, Zhao Zhong: Thiophene and furan derivatives as prostaglandin agonists and use thereof. Applied Research Systems Ars Holding, Araldi Gian Luca, Karra Srinivasa, Reddy Adulla P, Liao Yihua, Zhao Zhong, DECONTI Giulio A, February 12, 2004: WO/2004/012656 (8 worldwide citation)

Substituted furan and thienyl compounds are provided, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, ...


3

4
Goutopoulos Andreas, Askew Benny C Jr, Chen Xiaoling, Karra Srinivasa, Yu Henry: Novel heteroaryl-substituted arylaminopyridine derivatives as mek inhibitors. Laboratoires Serono, Goutopoulos Andreas, Askew Benny C Jr, Chen Xiaoling, Karra Srinivasa, Yu Henry, DAVIS Steven G, November 1, 2007: WO/2007/123936 (4 worldwide citation)

The invention provides novel heteroaryl-substituted arylaminopyridine derivative MEK inhibitors of Formula (Ia) Formula (Ia) Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed is the treatment of a hyperp ...


5
Huck Bayard R, Chen Xiaoling, de Selm Lizbeth Celeste, Jones Christopher Charles Victor, Karra Srinivasa R, Xiao Yufang, Goutopoulos Andreas, Sutton Amanda E: Protein kinase inhibitors and use thereof. Merck Serono, Huck Bayard R, Chen Xiaoling, de Selm Lizbeth Celeste, Jones Christopher Charles Victor, Karra Srinivasa R, Xiao Yufang, Goutopoulos Andreas, Sutton Amanda E, SEEMANN Joachim, September 3, 2009: WO/2009/108670 (4 worldwide citation)

Disclosed are benzonaphthyridinyl derivative compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to kinase signal transduction inhibition, regulation or modulation.


6
HOELZEMANN Guenter, EGGENWEILER Hans Michael, KARRA Srinivasa R: DÉRIVÉS DE PYRIDINE ET PYRAZINE, PYRIDINE-AND PYRAZINE DERIVATIVES. HOELZEMANN Guenter, EGGENWEILER Hans Michael, KARRA Srinivasa R, Merck Patent, BROWN Thomas W, November 29, 2012: WO/2012/161877 (3 worldwide citation)

Compounds of the formula (I) in which R, R1 and X have the meanings indicated in Claim 1, are inhibitors of TBK1 and IKKε and can be employed, inter alia, for the treatment of cancer and inflammatory diseases


7
Araldi Gian Luca, Karra Srinivasa, Zhao Zhong, Brugger Nadia: G-lactam derivatives as prostaglandin agonists. Applied Research Systems Ars Holding, Araldi Gian Luca, Karra Srinivasa, Zhao Zhong, Brugger Nadia, SERONO INTERNATIONAL INTELLECTUAL PROPERTY DEPARTMENT HASSA JUERGEN, September 16, 2004: WO/2004/078103 (2 worldwide citation)

The present invention relates ϝ-lactam derivatives, within the definitions of A, B, D, E, G, J, K, L, M, and N according to claims 1, in particular for use as medicaments, as well as pharmaceutical formulations containing such ϝ-lactam derivatives. Said ϝ-lactam derivatives are ...


8
KARRA Srinivasa R, STAEHLE Wolfgang, STAUB Eike, WUCHERER PLIETKER Margarita: DÉRIVÉS DE THIAZOLE, THIAZOLE DERIVATIVES. Merck Patent, KARRA Srinivasa R, STAEHLE Wolfgang, STAUB Eike, WUCHERER PLIETKER Margarita, BROWN Thomas W, November 29, 2012: WO/2012/161879

Compounds of the formula I in which R, R1, X and Y have the meanings indicated in Claim 1, are inhibitors of TBK1 and IKKε and can be employed, inter alia, for the treatment of cancer and inflammatory diseases.


9

10
XIAO Yufang, CHEN Xiaoling, KARRA Srinivasa R, HUCK Bayard R, SUTTON Amanda E, GOUTOPOULOS Andreas: [fr] NAPHTYRIDININONES EN TANT QU’INHIBITEURS D’AURORA KINASE, [en] NAPHTHYRIDININONES AS AURORA KINASE INHIBITORS. XIAO Yufang, CHEN Xiaoling, KARRA Srinivasa R, HUCK Bayard R, SUTTON Amanda E, GOUTOPOULOS Andreas, Merck Patent, SEEMANN Joachim, January 7, 2010: WO/2010/002779

[en] Naphthyridinone derivative compounds that inhibit Aurora kinase enzymes are disclosed along with pharmaceutical compositions comprising these compounds and methods for synthesizing the same. Such compounds have utility in the treatment of proliferative diseases resulting from unregulated and/or ...