1
Henry R Halperin, Ronald D Berger, Ergin Atalar, Elliot R McVeigh, Albert Lardo, Hugh Calkins, Joao Lima: Magnetic-resonance-guided imaging, electrophysiology, and ablation. Johns Hopkins University School of Medicine, Foley Hoag, March 2, 2004: US06701176 (225 worldwide citation)

A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic res ...


2
James G Herman, Stephen B Baylin: Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids. The Johns Hopkins University School of Medicine, Fish & Richardson P C, July 28, 1998: US05786146 (200 worldwide citation)

The present invention provides a method of PCR, methylation specific PCR (MSP), for rapid identification of DNA methylation patterns in a CpG-containing nucleic acid. MSP uses agents to modify unmethylated cytosine in a nucleic acid of interest, and then uses the PCR reaction to amplify the CpG-cont ...


3
Ergin Atalar, Jeffrey C Lestio, Harry K Charles Jr, Bliss G Carkhuff, Paul A Bottomley: Miniature magnetic resonance catheter coils and related methods. Johns Hopkins University School of Medicine, Foley Hoag & Eliot, July 17, 2001: US06263229 (162 worldwide citation)

The present invention provides several embodiments of methods of making magnetic resonance catheter coils which include employing a flexible electrically insulative base member, depositing an electrically conductive material on the base member in a predetermined pattern to create at least one pair o ...


4
Ergin Atalar, Ogan Ocali: Enhanced safety coaxial cables. Johns Hopkins University School of Medicine, Arnold B Silverman, Eckert Seamans Cherin & Mellott, September 4, 2001: US06284971 (155 worldwide citation)

A coaxial cable which may be a magnetic resonance imaging coaxial cable is designed for enhanced safety so as to reduce the risk of excessive heating or burns to a user. The cable has an elongated axially oriented inner conductor and an axially oriented outer shield conductor in spaced relationship ...


5
Henry R Halperin, Ronald D Berger, Ergin Atalar, Elliot R McVeigh, Albert Lardo, Hugh Calkins, Joao Lima: System and method for magnetic-resonance-guided electrophysiologic and ablation procedures. Johns Hopkins University School of Medicine, Nixon & Vanderhye P C, December 26, 2006: US07155271 (149 worldwide citation)

A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic res ...


6
Albert C Lardo, Xiaoming Yang, Ergin Atalar, Parag Karmarkar, Elliott R McVeigh, Henry R Halperin, Christine Enger McNamara, Paul A Bottomley: Magnetic resonance imaging guidewire probe. Johns Hopkins University School of Medicine, Surgi Vision, Foley Hoag, January 6, 2004: US06675033 (142 worldwide citation)

The invention describes a system, method, and means for an MRI guidewire that can be visible on an MRI, can act as an antenna and receive MRI signals from surrounding subject matter, and can allow the use of multiple interventional tools without removal of the guidewire from a subject.


7
James G Herman, Stephen B Baylin: Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguish modified methylated and non-methylated nucleic acids. The Johns Hopkins University School of Medicine, Lisa A Haile, Gray Cary Ware & Freidenrich, July 24, 2001: US06265171 (99 worldwide citation)

The present invention provides a method for detecting a methylated CpG-containing nucleic acid present in a specimen by contacting the specimen with an agent that modifies unmethylated cytosine and amplifying the CpG-containing nucleic acid using CpG-specific oligonucleotide primers. The present inv ...


8
Harry C Dietz: Delivery construct for antisense nucleic acids and methods of use. The Johns Hopkins University School of Medicine, Fish & Richardson P C, September 29, 1998: US05814500 (87 worldwide citation)

A novel nucleic acid construct for delivery of antisense targeting sequences is provided. The construct includes intact stem loop structures and an antisense nucleic acid. Optionally, a ribozyme nucleic acid is included in the construct. The construct is useful for inhibition of selected genes in a ...


9
James H Anderson, William R Brody, Chee Kong Chui, Yiyu Cai, Yaoping Wang, Wieslaw L Nowinski: Simulation method for designing customized medical devices. The Johns Hopkins University School of Medicine, Agency for Science Technology & Research, Peter F Corless, William J Daley Jr, Edwards Angell Palmer & Dodge, May 13, 2008: US07371067 (81 worldwide citation)

The invention provides a system for virtually designing a medical device conformed for use with a specific patient. Using the system, a three-dimensional geometric model of a patient-specific body cavity or lumen is reconstructed from scanned volume images such as obtained x-rays, magnetic resonance ...


10
Se Jin Lee, Alexandra C McPherron: Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same. The Johns Hopkins University School of Medicine, Lisa A Haile, Richard J Imbra, Gray Cary Ware & Freidenrich, December 2, 2003: US06656475 (81 worldwide citation)

The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In addition, the invention provides a virtual representation of a GDF receptor or a functional peptide portion ...