1
Mark S Humayun, Eugene de Juan Jr, Robert J Greenberg: Visual prosthesis and method of using same. John Hopkins University School of Medicine, Leydig Voit & Mayer, August 10, 1999: US05935155 (464 worldwide citation)

A visual prosthesis comprises a camera for perceiving a visual image and generating a visual signal output, retinal tissue stimulation circuitry adapted to be operatively attached to the user's retina, and wireless communication circuitry for transmitting the visual signal output to the retinal tiss ...


2
Se Jin Lee, Alexandra C McPherron: Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species. The John Hopkins University School of Medicine, Lisa A Haile, Richard J Imbra, Gary Cary Ware & Friedenrich, October 15, 2002: US06465239 (31 worldwide citation)

A transgenic non-human aquatic organisms, such as piscine, crustacea, mollusks, and the like, having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-8 (GDF-8) chromosomally integrated into the germ cells of the animal is disclosed. Also disc ...


3
Philip A Beachy, Michael K Cooper, Jeffrey A Porter: Inhibitors of hedgehog signaling pathways, compositions and uses related thereto. John Hopkins University School of Medicine, Ropes & Gray, November 6, 2007: US07291626 (27 worldwide citation)

The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.


4
Kenneth W Kinzler, Bert Vogelstein, Victor E Velculescu, Lin Zhang: Method for serial analysis of gene expression. The John Hopkins University School of Medicine, Banner & Witcoff, May 7, 2002: US06383743 (18 worldwide citation)

Serial analysis of gene expression, SAGE, a method for the rapid quantitative and qualitative analysis of transcripts is provided. Short defined sequence tags corresponding to expressed genes are isolated and analyzed. Sequencing of over 1,000 defined tags in a short period of time (e.g., hours) rev ...


5
Philip A Beachy, James K Chen, Anssi Jussi Nikolai Taipale: Regulators of the hedgehog pathway, compositions and uses related thereto. John Hopkins University School of Medicine, Ropes & Gray, January 13, 2009: US07476661 (17 worldwide citation)

The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog g ...


6
Eugene de Juan Jr: Use of an inhibitor of the protein tyrosine kinase pathway in the treatment of choroidal neovascularization. John Hopkins University School of Medicine, Leydig Voit & Mayer, February 22, 2000: US06028099 (15 worldwide citation)

The present invention is directed to a method for the prophylactic and therapeutic treatment of choroidal neovascularization. The method involves the administration of an inhibitor of the protein tyrosine kinase pathway to an animal, such as a mammal, in particular a human, in an amount sufficient t ...


7
Yuesheng Zhang, Tony W Ho, Yun Li: Prevention and treatment of degenerative diseases by glutathione and phase II detoxification enzymes. John Hopkins University School of Medicine, Foley & Lardner, November 2, 2004: US06812248 (10 worldwide citation)

The present invention generally relates to the field of treating degenerative disease by administering a pharmaceutically effective amount of a compound that elevates glutathione or at least one Phase II detoxification enzyme in diseased tissue. The present invention also relates to a pharmaceutical ...


8
David Sidransky: Method of detection of prostate cancer. The John Hopkins University School of Medicine, DLA Piper US, August 7, 2007: US07252935 (10 worldwide citation)

The present invention provides methods and kits useful for detecting neplasia by measuring the methylation level of biomarkers, especially the promoter region of GSTP1 for the detection of prostate adenocarcinoma.


9
John D Gearhart, Michael Joseph Shamblott: Human enbryonic germ cell and methods of use. The John Hopkins University School of Medicine, Lisa A Haile, Gray Cary Ware & Freidenrich, December 18, 2001: US06331406 (6 worldwide citation)

Primordial germ cells extracted from post blastocyst human embryos, such as from the gonadal ridges of a 8-11 week LMP human embryo, are disclosed. The primordial germ cells are cultured in long term culture (more than 30 days) resulting in cells that resemble embryonic stem cells in morphology and ...


10