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Jerôme Emile Georges Guillemont, David Francis Alain Lançois, Magali Madeleine Simone Motte, Anil Koul, Wendy Mia Albert Balemans, Eric Pierre Alexandre Arnoult: Antibacterial cyclopenta[c]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones. Janssen R&D Ireland, December 9, 2014: US08906923 (4 worldwide citation)

The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing thes ...


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Sandrine Marie Helene Vendeville, Pierre Jean Marie Bernard Raboisson, Tse I Lin, Abdellah Tahri, Katie Ingrid Eduard Amssoms: Macrocyclic indole derivatives useful as hepatitis C virus inhibitors. Janssen R & D Ireland, Andrea Jo Kamage, December 30, 2014: US08921355 (3 worldwide citation)

Inhibitors of HCV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R1, R2, R4, R5, R6 and R7 have the meaning defined in the claims. The present invention also relates to processes for preparing said compounds, pharmaceutical compos ...


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COOYMANS Ludwig Paul, DEMIN Samuël Dominique, HU Lili, JONCKERS Tim Hugo Maria, RABOISSON Pierre Jean Marie Bernard, TAHRI Abdellah, VENDEVILLE Sandrine Marie Helene: INHIBITEURS BENZIMIDAZOLES DU VIRUS RESPIRATOIRE SYNCYTIAL, BENZIMIDAZOLE RESPIRATORY SYNCYTIAL VIRUS INHIBITORS. JANSSEN R&D IRELAND, COOYMANS Ludwig Paul, DEMIN Samuël Dominique, HU Lili, JONCKERS Tim Hugo Maria, RABOISSON Pierre Jean Marie Bernard, TAHRI Abdellah, VENDEVILLE Sandrine Marie Helene, VAN WANROOIJ Eva, June 21, 2012: WO/2012/080446 (2 worldwide citation)

Benzimidazoles having inhibitory activity on RSV replication and having the formula (I) the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof, compositions containing these compounds as active ingredient and processes for preparing the ...


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VANDYCK Koen, LAST Stefaan Julien, RABOISSON Pierre Jean Marie Bernard: [fr] SULFAMOYL-ARYLAMIDES ET LEUR UTILISATION EN TANT QUE MÉDICAMENTS POUR LE TRAITEMENT DE LHÉPATITE B, [en] SULFAMOYL-ARYLAMIDES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B. JANSSEN R&D IRELAND, VAN WANROOIJ Eva, September 4, 2014: WO/2014/131847 (2 worldwide citation)

[en] Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, salts, hydrates and solvates thereof, wherein R1, R2, R3 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions c ...


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Kenneth Alan Simmen, Herman Augustinus De Kock, Pierre Jean Marie Bernard Raboisson, Lili Hu, Abdellah Tahri, Dominique Louis Nestor Ghislain Surleraux, Karl Magnus Nilsson, Bengt Bertil Samuelsson, Åsa Annica Kristina Rosenquist, Vladimir Ivanov, Mikael Pelcman, Anna Karin Gertrud Linnea Belfrage, Per Ola Mikael Johansson, Sandrine Marie Helene Vendeville: Macrocyclic inhibitors of hepatitis C virus. Janssen R&D Ireland, Medivir, Baker & Hostetler, June 3, 2014: US08741926 (1 worldwide citation)

Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is —OR7, —NH—SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hyd ...


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Paul Stoffels: Combinations of a pyrimidine containing NNRTI with RT inhibitors. Janssen R & D Ireland, Kirk Baumeister, September 23, 2014: US08841310 (1 worldwide citation)

The present invention concerns combinations of a pyrimidine containing NNRTI with nucleoside reverse transcriptase inhibitors and/or nucleotide reverse transcriptase inhibitors useful for the treatment of HIV infected patients or for the prevention of HIV transmission or infection.


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Ludwig Paul Cooymans, Samuël Dominique Demin, Lili Hu, Tim Hugo Maria Jonckers, Pierre Jean Marie Bernard Raboisson, Abdellah Tahri, Sandrine Marie Helene Vendeville: Indoles as respiratory syncytial virus antiviral agents. Janssen R&D Ireland, Mary A Appollina, December 30, 2014: US08921560 (1 worldwide citation)

Indoles having inhibitory activity on RSV replication and having the formula I the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compou ...


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Ludwig Paul Cooymans, Samuël Dominique Demin, Lili Hu, Tim Hugo Maria Jonckers, Pierre Jean Marie Bernard Raboisson, Abdellah Tahri, Sandrine Marie Helene Vendeville: Benzimidazole respiratory syncytial virus inhibitors. Janssen R&D Ireland, Mary A Appollina, October 21, 2014: US08865705 (1 worldwide citation)

Benzimidazoles having inhibitory activity on RSV replication and having the formula the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof, compositions containing these compounds as active ingredient and processes for preparing these c ...