1
Pierre Jean Fran├žois Layrolle, Klaas de Groot, Joost Dick de Bruijn, Clemens A van Blitterswijk, Yuan Huipin: Method for coating medical implants. IsoTis, John P Iwanicki, Banner & Witcoff, March 27, 2001: US06207218 (82 worldwide citation)

The present invention relates to a method for coating a medical implant, wherein the implant is submersed in an aqueous solution of magnesium, calcium and phosphate ions through which a gaseous weak acid is passed, the solution is degassed, and the coating is allowed to precipitate onto the implant. ...


2
Eugenia Ribeiro de Sousa Fidalgo Leitao: Implant material. IsoTis, Banner & Witcoff, May 30, 2000: US06069295 (67 worldwide citation)

The invention provides a nanotechnology process for implant surface treatment for producing an implant article. The nanotechnology process comprises subjecting a non-porous material to a mechanical or chemical surface treatment until a surface roughness with an average peak distance (Ra value) betwe ...


3
Eugenia Ribeiro de Sousa Fidalgo Leitao, Joost Dick De Bruijn, Hai Bo Wen, Klaas De Groot: Device for incorporation and release of biologically active agents. IsoTis, Banner & Witcoff, February 5, 2002: US06344061 (64 worldwide citation)

The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipis, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process ...


4
Eugenia Ribeiro de Sousa Fidalgo Leitao, Joost Dick De Bruijn, Hai Bo Wen, Klaas De Groot: Device for incorporation and release of biologically active agents. IsoTis, Banner & Witcoff, October 24, 2000: US06136369 (52 worldwide citation)

The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipis, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process ...


5

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Eugenia Ribeiro de Sousa Fildago Leitao: Implant material and process for using it. IsoTis, Banner & Witcoff, November 14, 2000: US06146686 (43 worldwide citation)

The invention provides a nanotechnology process for implant surface treatment for producing an implant article. The nanotechnology process comprises subjecting a non-porous material to a mechanical or chemical surface treatment until a surface roughness with an average peak distance (Ra value) betwe ...


7
Joost D de Bruijn, Klaas de Groot, Clemens A van Blitterswijk, Yuan Huipin: Osteoinductive ceramic materials. IsoTis, Banner & Witcoff, January 28, 2003: US06511510 (43 worldwide citation)

The invention relates to an osteoinductive biomaterial, which is based on a ceramic material and which has a total porosity of 20 to 90%, wherein macropores are present having a size ranging from 0.1 to 1.5 mm, and wherein micropores are present having a size ranging from 0.05 to 20 &mgr;m. The inve ...


8
Shihong Li, Klaas de Groot, Pierre Jean F Layrolle, Clemens Antoni van Blitterswijk, Joost Robert de Wijn: Porous ceramic body. IsoTis, Banner & Witcoff, November 12, 2002: US06479418 (41 worldwide citation)

The invention relates to a process for preparing a porous ceramic body, which process is based on a negative replica method. The invention further relates to a ceramic body obtainable by said method and to its use as a scaffold for tissue engineering.


9
Tahir Mahmood, Jens Uwe Riesle, Clemens Antoni van Blitterswijk: Scaffold for tissue engineering cartilage having outer surface layers of copolymer and ceramic material. IsoTis, Banner & Witcoff, February 17, 2004: US06692761 (37 worldwide citation)

A biodegradable, biocompatible porous matrix as a scaffold for tissue engineering cartilage is formed of a copolymer of a polyalkylene glycol and an aromatic polyester such as a polyethylene glycol/polybutylene terephtalate copolymer. A ceramic coating such as a calcium phosphate coating may be prov ...


10
Pierre Jean Fran├žois Layrolle, Klaas de Groot, Joost Dick de Bruijn, Clemens A van Blitterswijk, Yuan Huipin: Method for coating medical implants. IsoTis, Banner & Witcoff, May 11, 2004: US06733503 (36 worldwide citation)

The present invention relates to a method for coating a medical implant, wherein the implant is submersed in an aqueous solution of magnesium, calcium and phosphate ions through which a gaseous weak acid is passed, the solution is degassed, and the coating is allowed to precipitate onto the implant. ...