1
Edgardo Baracchini, C Frank Bennett, Nicholas M Dean: Antisense oligonucleotide modulation of multidrug resistance-associated protein. Isis Pharmaceuticals, Law Offices of Jane Massey Licata, September 1, 1998: US05801154 (518 worldwide citation)

Compositions and methods are provided for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of the synthesis or metabolism of multidrug resistance-associated protein (MRP). In accordance with referred embodiments, oligonucleotides are provided which are s ...


2
Alain De Mesmaeker, Jacques Lebreton, Adrian Waldner, Phillip D Cook: Backbone modified oligonucleotide analogs. Ciba-Geigy, Isis Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, February 11, 1997: US05602240 (473 worldwide citation)

Oligonucleotide analogs are provided wherein phosphodiester inter-sugar linkages are replaced with four atom linking groups. Such linking groups include NR--C(O)--CH.sub.2 --CH.sub.2, NR--C(S)--CH.sub.2 --CH.sub.2, CH.sub.2 --NR--C(O)--CH.sub.2, CH.sub.2 --NR--C(S)--CH.sub.2, CH.sub.2 --CH.sub.2 --N ...


3
Oscar L Acevedo, Normand Hebert: Pyrrolidine-containing monomers and oligomers. Isis Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, May 21, 1996: US05519134 (401 worldwide citation)

Novel pyrrolidine monomers bearing various functional groups are used to prepare oligomeric structures. The pyrrolidine monomers can be joined via standard phosphate linkages including phosphodiester and phosphorothioate linkages. Useful functional groups include nucleobases as well as polar groups, ...


4
P Dan Cook, Kanda S Ramasamy, Muthiah Manoharan: N-2 substituted purines. Isis Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, October 17, 1995: US05459255 (356 worldwide citation)

This invention presents novel purine-based compounds for inclusion into oligonucleotides. The compounds of the invention, when incorporated into oligonucleotides are especially useful as agents that are capable of specific hybridization with a nucleotide sequence of an RNA. Oligonucleotides are used ...


5
Yogesh S Sanghvi, Phillip D Cook: Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms. ISIS Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, February 6, 1996: US05489677 (352 worldwide citation)

Novel compounds that mimic and/or modulate the activity of wild-type nucleic acids. In general, the compounds contain a selected nucleoside sequence wherein the nucleosides are covalently bound through linking groups that contain adjacent nitrogen atoms.


6
Philip D Cook, Charles J Guinosso: Polyamine conjugated oligonucleotides. ISIS Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, August 11, 1992: US05138045 (331 worldwide citation)

Oligonucleotide analogs are provided having improved cellular uptake and improved nuclease resistance. Modification of oligonucleotides through the attachment of nitrogenous moieties, especially polyamines, hydrazines and the like to nucleosidic portions of the analogs is disclosed. Oligonucleotides ...


7
Phillip Dan Cook, Andrew Mamoro Kawasaki: Sugar modified oligonucleotides that detect and modulate gene expression. ISIS Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, September 23, 1997: US05670633 (329 worldwide citation)

Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected seq ...


8
Phillip D Cook, Yogesh S Sanghvi, Jean J Vasseur, Francoise Debart: Backbone modified oligonucleotide analogues. Isis Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, March 11, 1997: US05610289 (307 worldwide citation)

Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligomers with four atom linking groups forms unique di- and poly- nucleosides and nucleotides use ...


9
Phillip D Cook, Kelly Teng: Conjugated 4-desmethyl nucleoside analog compounds. ISIS Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, March 4, 1997: US05608046 (291 worldwide citation)

Tetrahydrofuranyl compounds are provided that are functionalized to include pendant conjugate groups, and which are useful in diagnostic assays and as research reagents. Novel intermediates for the synthesis of the compounds are also provided.


10
Phillip D Cook, Glenn Hoke: Oligonucleotides having phosphorothioate linkages of high chiral purity. Isis Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, December 24, 1996: US05587361 (285 worldwide citation)

Sequence-specific phosphorothioate oligonucleotides comprising nucleoside units which are joined together by either substantially all Sp or substantially all Rp phosphorothioate intersugar linkages are provided. Such sequence-specific phosphorothioate oligonucleotides having substantially chirally p ...



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