1
Edgardo Baracchini, C Frank Bennett, Nicholas M Dean: Antisense oligonucleotide modulation of multidrug resistance-associated protein. Isis Pharmaceuticals, Law Offices of Jane Massey Licata, September 1, 1998: US05801154 (540 worldwide citation)

Compositions and methods are provided for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of the synthesis or metabolism of multidrug resistance-associated protein (MRP). In accordance with referred embodiments, oligonucleotides are provided which are s ...


2
Alain De Mesmaeker, Jacques Lebreton, Adrian Waldner, Phillip D Cook: Backbone modified oligonucleotide analogs. Ciba-Geigy, Isis Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, February 11, 1997: US05602240 (525 worldwide citation)

Oligonucleotide analogs are provided wherein phosphodiester inter-sugar linkages are replaced with four atom linking groups. Such linking groups include NR--C(O)--CH.sub.2 --CH.sub.2, NR--C(S)--CH.sub.2 --CH.sub.2, CH.sub.2 --NR--C(O)--CH.sub.2, CH.sub.2 --NR--C(S)--CH.sub.2, CH.sub.2 --CH.sub.2 --N ...


3
Oscar L Acevedo, Normand Hebert: Pyrrolidine-containing monomers and oligomers. Isis Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, May 21, 1996: US05519134 (434 worldwide citation)

Novel pyrrolidine monomers bearing various functional groups are used to prepare oligomeric structures. The pyrrolidine monomers can be joined via standard phosphate linkages including phosphodiester and phosphorothioate linkages. Useful functional groups include nucleobases as well as polar groups, ...


4
P Dan Cook, Kanda S Ramasamy, Muthiah Manoharan: N-2 substituted purines. Isis Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, October 17, 1995: US05459255 (395 worldwide citation)

This invention presents novel purine-based compounds for inclusion into oligonucleotides. The compounds of the invention, when incorporated into oligonucleotides are especially useful as agents that are capable of specific hybridization with a nucleotide sequence of an RNA. Oligonucleotides are used ...


5
Yogesh S Sanghvi, Phillip D Cook: Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms. ISIS Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, February 6, 1996: US05489677 (384 worldwide citation)

Novel compounds that mimic and/or modulate the activity of wild-type nucleic acids. In general, the compounds contain a selected nucleoside sequence wherein the nucleosides are covalently bound through linking groups that contain adjacent nitrogen atoms.


6
Phillip Dan Cook, Andrew Mamoro Kawasaki: Sugar modified oligonucleotides that detect and modulate gene expression. ISIS Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, September 23, 1997: US05670633 (354 worldwide citation)

Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected seq ...


7
Philip D Cook, Charles J Guinosso: Polyamine conjugated oligonucleotides. ISIS Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, August 11, 1992: US05138045 (352 worldwide citation)

Oligonucleotide analogs are provided having improved cellular uptake and improved nuclease resistance. Modification of oligonucleotides through the attachment of nitrogenous moieties, especially polyamines, hydrazines and the like to nucleosidic portions of the analogs is disclosed. Oligonucleotides ...


8
Phillip D Cook, Yogesh S Sanghvi, Jean J Vasseur, Francoise Debart: Backbone modified oligonucleotide analogues. Isis Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, March 11, 1997: US05610289 (330 worldwide citation)

Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligomers with four atom linking groups forms unique di- and poly- nucleosides and nucleotides use ...


9
Phillip D Cook, Kelly Teng: Conjugated 4-desmethyl nucleoside analog compounds. ISIS Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, March 4, 1997: US05608046 (313 worldwide citation)

Tetrahydrofuranyl compounds are provided that are functionalized to include pendant conjugate groups, and which are useful in diagnostic assays and as research reagents. Novel intermediates for the synthesis of the compounds are also provided.


10
Stanley T Crooke: Oligoribonucleotides and ribonucleases for cleaving RNA. Isis Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, August 22, 2000: US06107094 (308 worldwide citation)

Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinity to complementa ...