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Hong Liu, Xiaohui He, Dean Phillips, Xuefeng Zhu, Kunyong Yang, Thomas Lau, Baogen Wu, Yongping Xie, Truc Ngoc Nguyen, Xing Wang: Compounds and compositions as inhibitors of cannabinoid receptor 1 activity. IRM A Delaware Liability Company, Genomics Institute of the Novartis Research Foundation, Chihang Amy Smith, April 30, 2013: US08431607

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).


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Michael P Cooke: Methods and compositions for modulating stem cells. IRM a Delaware Liability Company, Genomics Institute Of The, Novartis Research Foundation, December 2, 2004: US20040241856-A1

The invention provides methods for inhibiting stem cell differentiation and for increasing the effective dose of stem cells in a subject. HSC differentiation can be inhibited by applying an HSC differentiation-inhibiting polypeptide identified in the present invention to an HSC culture in vitro, or ...


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Quinn L Deveraux, Klaus W Wagner, Garrett M Hampton: Diagnosis and treatment of chemoresistant tumors. IRM a Delaware Liability Company, Townsend And Townsend And Crew, May 27, 2004: US20040101915-A1

This invention provides methods of identifying compounds that selectively target cancer cells that have defects in specific oncogenic pathways.


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Sumit Chanda, Suhaila White, John B Hogenesch, Jeremy S Caldwell: Methods and compositions for modulating activator protein 1. IRM a Delaware Liability Company, Timothy L Smith, Genomics Institute Of The, July 29, 2004: US20040146903-A1

This invention provides novel AP-1 modulatory polypeptides. The invention also provides methods for screening modulators of AP-1 transcription factor activities. The methods comprise first screening test agents for modulators of an AP-1-modulatory polypeptide and then further screening the identifie ...


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Michael P Cooke, Karsten Sauer, Tim Wiltshire, Lisa Tarantino, Colin Fletcher, Ben Wen: Methods and compositions for modulating T lymphocytes. IRM a Delaware Liability Company, Genomics Institute Of The, Novartis Research Foundation, December 30, 2004: US20040265790-A1

This invention provides novel methods and compositions for modulating T cell differentiation and T cell responses. The modulators are identified by screening test compounds for ability to modulate an inositol 1,4,5-trisphosphate 3-kinase (IP3K). The IP3K modulators can be further examined for their ...


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Shifeng Pan, Nathanael S Gray, Yuan Mi, Yi Fan, Wengi Gao: Immunosuppressant compounds and compositions. IRM a Delaware Liability Company, Genomics Institute Of The, Novartis Research Foundation, January 13, 2005: US20050009786-A1

The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particul ...


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Frantisek Supek, Nicholas Gekakis: Differential tag length analysis of cell proliferation. IRM a Delaware Liability Company, Townsend And Townsend And Crew, January 13, 2005: US20050009052-A1

The present invention is based on a novel cell tagging approach called “Differential Tag Length” method (DTLA) that allows the quantitative analysis of a mixture of multiple cell types (e.g., strains) grown in very small cultivation volumes. DTLA can also be fully automated and adapted for a high-th ...


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Sheng Hao Chao, Jeremy S Caldwell: Methods and compositions for inhibiting herpesviral replication. IRM a Delaware Liability Company, Genomics Institute Of The, Novartis Research Foundation, March 17, 2005: US20050058991-A1

This invention provides methods of screening for compounds that inhibit herpesviral transcription and replication. The methods comprise screening test compounds for ability to enhance the activity of homeodomain transcription factor PDX1 in repressing transcription of herpesviral genes (e.g., the IE ...


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Thomas H Marsilje, Nathanel S Gray, Tao Jiang, Wenshuo Lu, Shifeng Pan: Immunosuppressant compounds and compositions. IRM a Delaware Liability Company, Genomics Institute Of The, Novartis Research Foundation, January 20, 2005: US20050014724-A1

The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particul ...