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Kristina Marie Burow, Jeremy S Caldwell, Robert Charles Downs, Scott Allan Lesley, James Kevin Mainquist, Andrew J Meyer, Daniel G Sipes, Mark Richard Weselak: High throughput processing system and method of using. IRM, Timothy L Smith, Genomics Institute of the Novartis Research Foundation, June 24, 2008: US07390458 (103 worldwide citation)

Briefly, the present invention provides a system and method for high throughput processing using sample holders. The system has a plurality of work perimeters, with a rotational robot preferably associated with each work perimeter. At least one transfer station area is provided between adjacent work ...


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Nagle Advait, Gray Nathanael Schiander, Liu Yi, Ren Pingda, Sim Taebo, You Shuli: Compounds and compositions as protein kinase inhibitors. Irm, Nagle Advait, Gray Nathanael Schiander, Liu Yi, Ren Pingda, Sim Taebo, You Shuli, KONZAK Kristin E, November 23, 2006: WO/2006/124462 (66 worldwide citation)

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal act ...


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Michellys Pierre Yves, Wen Ke, Petrassi Michael H, Pei Wei: Diarylamine-containing compounds and compositions, and their use as modulators of steroid hormone nuclear receptors. Irm, Michellys Pierre Yves, Wen Ke, Petrassi Michael H, Pei Wei, HOSTETLER Michael J, October 12, 2006: WO/2006/108107 (62 worldwide citation)

Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of steroid hormone nuclear receptors, and pharmaceutical compositions and medicaments comprising such c ...


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Cheng Dai, Ding Qiang, Han Dong, Gray Nathanael Schiander, Zhang Guobao: 6-substituted anilino purines as rtk inhibitors. Irm, Cheng Dai, Ding Qiang, Han Dong, Gray Nathanael Schiander, Zhang Guobao, REID Scott W, February 24, 2005: WO/2005/016528 (62 worldwide citation)

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with cSRC, Lck, FGFR3, Flt3, TrkB, Bmx, and/or PFGFR&agr; kinase activity.


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Michellys Pierre Yves, Pei Wei, Marsilje Thomas H, Lu Wenshuo, Chen Bei, Uno Tetsuo, Jin Yunho, Jiang Tao: Compounds and compositions as protein kinase inhibitors. Irm, Michellys Pierre Yves, Pei Wei, Marsilje Thomas H, Lu Wenshuo, Chen Bei, Uno Tetsuo, Jin Yunho, Jiang Tao, TONGCO WU Emily, June 19, 2008: WO/2008/073687 (58 worldwide citation)

The invention provides novel pyrimidine and pyridine derivatives of formula (I) and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds ...


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Obaid U Alvi, Irfan A Toor: Plasma arc decomposition of hazardous wastes into vitrified solids and non-hazardous gasses. IRM, Warren & Perez, July 30, 1996: US05541386 (57 worldwide citation)

A disposal of waste material including water, volatile components and vitrifiable components, the waste material is heated in a dehydrator to remove the water, heated in a high-temperature dryer to vaporize hydrocarbon liquids, and then fed to the focus point of a primary plasma reactor where plasma ...


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Epple Robert, Cow Christopher, Xie Yongping, Wang Xing, Russo Ross, Azimioara Mihai, Saez Enrique: Compounds and compositions as ppar modulators. Irm, Epple Robert, Cow Christopher, Xie Yongping, Wang Xing, Russo Ross, Azimioara Mihai, Saez Enrique, REID Scott W, December 8, 2005: WO/2005/116000 (54 worldwide citation)

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.


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Ding Qiang, Sim Tae Bo, Zhang Guobao, Adrian Francisco, Gray Nathanael S: Novel compounds and compositions as protein kinase inhibitors. Irm, Ding Qiang, Sim Tae Bo, Zhang Guobao, Adrian Francisco, Gray Nathanael S, GARRETT WACKOWSKI Eugenia, October 21, 2004: WO/2004/089286 (52 worldwide citation)

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated tyrosine kinase activity, particularly diseases associated with the activity ...


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Okram Barun, Ren Pingda, Gray Nathanael S: Pyrrolopyridine derivatives as protein kinase inhibitors. Irm, The Scripps Research Institute, Okram Barun, Ren Pingda, Gray Nathanael S, REID Scott W, November 23, 2006: WO/2006/124863 (51 worldwide citation)

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal act ...