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Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva: Use of compounds to enhance processivity of telomerase. Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic, Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva, GABRIELOVA Marta, November 2, 2006: WO/2006/114064 (52 worldwide citation)

The invention provides the use of acyclic nucleoside phosphonates and their derivatives for the preparation of a medicament for enhancing the processivity of a telomerase increasing the number of mitotic cycles and mitotic cell division.


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Balzarini Jan M R, de, Clercq Erik Desire Alice, Holy Antonin: (phosphonomethoxy)Alkoxy pyrimidine derivatives having antiviral activity. Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic, Rega Stichting Vzw, Balzarini Jan M R, de, Clercq Erik Desire Alice, Holy Antonin, GABRIELOVÁ Marta, January 9, 2003: WO/2003/002580

Novel compounds are provided having formula (I), where R¿1?, R¿2?, R¿3?, R¿4?, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).


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Martin John C, Bronson Joanne J, Yu Kuo Long: Antiviral acyclic phosphonomethoxyalkyl substituted, alkenyl and alkynyl purine and pyrimidine derivatives. Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic, Rega Stichling Vzw, HENSLEY Max D, April 15, 1993: WO/1993/007157

Disclosed are acyclic phosphonomethoxyalkyl substituted, alkenyl and alkynyl purine and pyrimidine derivatives and a pharmaceutical composition comprising said purine and pyrimidine derivatives. The compounds are useful in the treatment of viral infections, especially those caused by human immunodef ...



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