1
Antonin Holy, Erik Desire Alice De Clercq: N.sup.6 - substituted nucleotide analagues and their use. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, November 2, 1999: US05977061 (100 worldwide citation)

Novel PMP, PME and HPMP and related compounds containing N-6 substituted 2,6-diaminopurine and adenine bases are provided. These compounds are useful in a variety of utilities, including as intermediates in the preparation of flame retardants, diagnostic reagents and therapeutics, including antivira ...


2
John E Starrett Jr, Muzammil M Mansuri, John C Martin, David R Tortolani, Joanne J Bronson: Prodrugs of phosphonates. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, September 2, 1997: US05663159 (95 worldwide citation)

There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.


3
John E Starrett Jr, Muzammil M Mansuri, John C Martin, David R Tortolani, Joanne J Bronson: Prodrugs of phosphonates. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, August 11, 1998: US05792756 (75 worldwide citation)

There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.


4
Antonin Holy, Hana Dvorakova, Erik Desire Alice DeClercq, Jan Marie Rene Balzarini: Antiretroviral enantiomeric nucleotide analogs. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, May 2, 2000: US06057305 (68 worldwide citation)

Resolved enantiomers of the formula ##STR1## wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections.


5

6
Muzammil M Mansuri, John C Martin, Thomas W Hudyma, Joanne J Bronson, Louis M Ferrara: Phosphonomethoxy carbocyclic nucleosides and nucleotides. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Mark L Bosse, April 28, 1998: US05744600 (27 worldwide citation)

A compound of the Formula I or Formula II ##STR1## wherein R.sup.1 and R.sup.2 are independently hydrogen, hydroxy, chlorine, fluorine, bromine, or an organic substituent having 1 to 5 carbon atoms and selected from acyloxy having a hydrocarbon stem of 1 to 4 carbon atoms, alkoxy, alkylthio, amino, ...


7
Purushortham Vemishetti, Paul R Brodfuehrer, Henry G Howell, Chester Sapino Jr: Process for the preparation of nucleotides. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, December 19, 1995: US05476938 (16 worldwide citation)

The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.


8
Robert W Webb II, Joanne J Bronson, John C Martin: Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, July 22, 1997: US05650510 (15 worldwide citation)

A series of compounds of Formula I which have anti-tumor activity, and are useful in treating viral infections, their compositions and use. ##STR1## In Formula I B is a purine or pyrimidine base; alk.sub.1 alk.sub.2 and alk.sub.3 are chemical bonds or alkylene groups; Q is hydrogen or hydroxyl; and ...


9
Robert W Webb II, Joanne J Bronson, John C Martin: Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, December 29, 1998: US05854228 (14 worldwide citation)

A series of compounds of Formula I which have anti-tumor activity, and are useful in treating viral infections, their compositions and use. ##STR1## In Formula I B is a purine or pyrimidine base; alk.sub.1 alk.sub.2 and alk.sub.3 are chemical bonds or alkylene groups; Q is hydrogen or hydroxyl; and ...


10
Kuo Long Yu, Joanne J Bronson, John C Martin: Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, April 12, 1994: US05302585 (11 worldwide citation)

The present invention provides chiral nucleotide analogs having the Formulas I and II ##STR1## and pharmaceutically acceptable salts and solvates thereof, and their pharmaceutical compositions for use in the treatment of viral infections, especially those caused by human immunodeficiency virus (HIV) ...



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