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Tam Huynh Dinh, Catherine Gouyette, Jean Igolen: 2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted adenosine-3-phosphoramidites. Institut Pasteur, Centre National de la Recherce Scientifique, Fleit Jacobson Cohn Price Holman & Stern, July 4, 1989: US04845205 (186 worldwide citation)

The invention concerns 2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted adenosine nucleosides in which the sugar component is substituted at position 3' or position 5' by a phosphite or phosphoramidite group of the formula: ##STR1## R.sub.1 representing a lower alkyl or --(CH.sub.2).sub.n --CN ...


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Georges Chacornac: Multi-penetration vaccination apparatus. Manufacture Francaise d Armes et Cycles de Saint Etienne Manufrance, Institut Pasteur, Haseltine Lake & Waters, August 29, 1978: US04109655 (140 worldwide citation)

A multi-penetration vaccination apparatus comprising a mounting having on e side a manually engageable portion for the handling of the apparatus and on the other side one or more levels of supports adapted for removable press-fit of one extremity of concentric sleeves, the free extremity of the slee ...


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Stratis Avrameas, Therese M F Ternynck: Process for coupling biological substances by covalent bonds. Etablissement DeClare d Utilite Publique dit Institut Pasteur, Sprung Felfe Horn Lynch & Kramer, March 18, 1980: US04193982 (99 worldwide citation)

A process for coupling biological substances by covalent bonds that involves the use of benzoquinone as cross-linking agent in large excess compared with the substance to be activated. The activation reaction is realized in a homogeneous liquid medium. The process makes it possible, for example, to ...


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Philippe Moullier, Olivier Danos, Jean Michel Heard, Nicolas Ferry: Biocompatible implant for the expression and in vivo secretion of a therapeutic substance. Institut Pasteur, Oblon Spivak McClelland Maier & Neustadt P C, May 25, 1999: US05906817 (87 worldwide citation)

The invention relates to an implant obtained by assembling in vitro various elements in order to form a neo-organ which is introduced preferably in the peritoneal cavity of the recipient. The implant comprises a biocompatible support intended to the biological anchoring of cells; cells having the ca ...


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Christine Gengoux Sedlik, Claude LeClerc: Antigen-carrying microparticles and their use in the indication of humoral or cellular responses. Institut Pasteur, Bierman Muserlian and Lucas, February 16, 1999: US05871747 (83 worldwide citation)

The invention concerns the use, in the induction of an immune response, of a synthetic microparticle polymer carrying on the surface one or more covalently bonded proteins capable of carrying one or more epitopes, the densities of the protein(s) on the surface of the microparticles, and their molecu ...


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Bruno Canard, Simon Sarfati: Derivatives utilizable in nucleic acid sequencing. Institut Pasteur, Oblon Spivak McClelland Maier & Neustadt P C, August 25, 1998: US05798210 (62 worldwide citation)

Deoxyribonucleotide 5' triphosphate (dNTP) or ribonucleotide 5' triphosphate (NTP) esters for use in a nucleic acid sequencing process without use of a gel and having one o formulae (I), (II), (III) or (IV).


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Hughes B De The, Agnes Marchio, Pierre Tiollais, Anne DeJean, Nigel Brand, Martin Petkovich, Andree Krust, Pierre Chambon: Steroid/thyroid hormone receptor-related gene, which is inappropriately expressed in human heptocellular carcinoma, and which is a retinoic acid receptor. Institut Pasteur, Finnegan Henderson Farabow Garrett & Dunner, December 27, 1994: US05376530 (58 worldwide citation)

A previously isolated hepatitis B virus (HBV) integration in a 147 bp cellular DNA fragment linked to hepatocellular carcinoma (HCC) was used as a probe to clone the corresponding complementary DNA from a human liver cDNA library. Nucleotide sequence analysis revealed that the overall structure of t ...



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