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Sun Lijun, Borella Christopher, Li Hao, Jiang Jun, Chen Shoujun, Koya Keizo, Inoue Takayo, Du Zhenjian, Foley Kevin, Wu Yaming, Zhang Mei, Ying Weiwen: Isoxazole combretastin derivatives for the treatment of disorders. Synta Pharmaceuticals, Sun Lijun, Borella Christopher, Li Hao, Jiang Jun, Chen Shoujun, Koya Keizo, Inoue Takayo, Du Zhenjian, Foley Kevin, Wu Yaming, Zhang Mei, Ying Weiwen, DAVIS Steven G, August 24, 2006: WO/2006/089177 (40 worldwide citation)

The invention relates to compounds of structural formula (I); or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative ...


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Kostik Elena, Vaghefi Farid, Liang Guiqing, Koya Keizo, Sun Lijun, Tatsuta Noriaki, Chen Shoujun, Inoue Takayo, Xia Zhi Qiang: Bis(thio-hydrazide amide) salts for treatment of cancers. Synta Pharmaceuticals, Kostik Elena, Vaghefi Farid, Liang Guiqing, Koya Keizo, Sun Lijun, Tatsuta Noriaki, Chen Shoujun, Inoue Takayo, Xia Zhi Qiang, DAVIS Steven G, January 26, 2006: WO/2006/009940 (18 worldwide citation)

Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I) Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R1-R4 are independently -H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted ar ...


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Tatsuta Noriaki, Koya Keizo, Inoue Takayo: Oral formulations of bis(thiohydrazide amides). Synta Pharmaceuticals, Tatsuta Noriaki, Koya Keizo, Inoue Takayo, DAVID Steven G, May 22, 2009: WO/2009/064374 (11 worldwide citation)

Disclosed herein are oral formulations of bis(thio-hydrazide amides) compounds of the following structural formula (I) : or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R7, R8, Z, and Y are defined herein.