1
Preeti Lal, Karl J Guegler, Neil C Corley: Human ena/VASP-like protein splice variant. Incyte Corporation, Incyte Corporation, November 11, 2003: US06645499 (84 worldwide citation)

The invention provides a human ena/VASP-like protein splice variant (EVL1) and polynucleotides which identify and encode EVL1. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders a ...


2
Rodgers James D, Wang Heisheng, Combs Andrew P, Sparks Richard B: Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2m3-b]pyrimidin-4-yl-amines as janus kinase inhibitors. Incyte Corporation, Rodgers James D, Wang Heisheng, Combs Andrew P, Sparks Richard B, GODDARD Christine A, June 29, 2006: WO/2006/069080 (58 worldwide citation)

The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.


3

4
Yao Wenqing, He Chunhong, Zhuo Jincong: Inhibitors of 11-&bgr; hydroxyl steroid dehydrogenase type 1 and methods of using the same. Incyte Corporation, Yao Wenqing, He Chunhong, Zhuo Jincong, GODDARD Christine A, May 26, 2006: WO/2006/055752 (52 worldwide citation)

The present invention relates to inhibitors of 11-&bgr; hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or ...


5
Zhuo Jincong, Xu Meizhong, He Chunhong, Zhang Colin, Qian Ding Quan, Burns David M, Li Yunlong, Metcalf Brian, Yao Wenqing: Imidazotriazines and imidazopyrimidines as kinase inhibitors. Incyte Corporation, Zhuo Jincong, Xu Meizhong, He Chunhong, Zhang Colin, Qian Ding Quan, Burns David M, Li Yunlong, Metcalf Brian, Yao Wenqing, GODDARD Christine PhD, May 29, 2008: WO/2008/064157 (52 worldwide citation)

The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.


6
Schmidt Jeanette P, Wright Rachel J, Bruns Christopher M, Marjanovic Mirjana M, Shen Fan, Harthshorne Toinette A, Suchorolski Martin T, Altus Christina M, Pitts Steven J, Elder Linda V, Mooney Elizabeth M, Delegeane Angelo M, Panesar Iqbal S, Banville Steven C, Reddy Thirupathi P, Stevens Kristian A, Blanchard John L, Panzer Scott R, Wang Xinhao, Au Alan P, Gerstin Jr Edward H, Peralta Careyna H, Anderson Scott B, Rioux Pierre, Shen Edward J, Wu Mingham C, Stuve Laura L, Lagace Robert E, Spiro Peter A, Stewart Elizabeth A, Wingrove James, Vitt Ursula A, Kirton Edward S, Xu Yuming, Kwong Mary, Policky Jennifer L, Hurwitz Bonnie L, Ma Yan, Jackson Jennifer L, Gietzen Darryl, Patury Srikanth, Shi Xiaobing, Suarez Charlyn J: Molecules for diagnostics and therapeutics. Incyte Corporation, Schmidt Jeanette P, Wright Rachel J, Bruns Christopher M, Marjanovic Mirjana M, Shen Fan, Harthshorne Toinette A, Suchorolski Martin T, Altus Christina M, Pitts Steven J, Elder Linda V, Mooney Elizabeth M, Delegeane Angelo M, Panesar Iqbal S, Banville Steven C, Reddy Thirupathi P, Stevens Kristian A, Blanchard John L, Panzer Scott R, Wang Xinhao, Au Alan P, Gerstin Jr Edward H, Peralta Careyna H, Anderson Scott B, Rioux Pierre, Shen Edward J, Wu Mingham C, Stuve Laura L, Lagace Robert E, Spiro Peter A, Stewart Elizabeth A, Wingrove James, Vitt Ursula A, Kirton Edward S, Xu Yuming, Kwong Mary, Policky Jennifer L, Hurwitz Bonnie L, Ma Yan, Jackson Jennifer L, Gietzen Darryl, Patury Srikanth, Shi Xiaobing, Suarez Charlyn J, HAMLET COX Diana, March 25, 2004: WO/2004/023973 (52 worldwide citation)

The present invention provides purified human polynucleotides for diagnostics and therapeutics (dithp). Also encompassed are the polypeptides (DITHP) encoded by dithp. The invention also provides for the use of dithp, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The i ...


7
James D Rodgers, Stacey Shepard: Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors. Incyte Corporation, Fish & Richardson P C, October 6, 2009: US07598257 (50 worldwide citation)

The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related disea ...


8
Yao Wenqing, Zhuo Jincong, Xu Meizhong, Zhang Colin, Metcalf Brian, He Chunhong, Qian Ding Quan: Amido compounds and their use as pharmaceuticals. Incyte Corporation, Yao Wenqing, Zhuo Jincong, Xu Meizhong, Zhang Colin, Metcalf Brian, He Chunhong, Qian Ding Quan, GODDARD Christine A Ph D, November 24, 2005: WO/2005/110992 (50 worldwide citation)

The present invention relates to inhibitors of 11-ß hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or acti ...


9
Benjamin G Cocks, Susan G Stuart, Jeffrey J Seilhamer: Compositions for the detection of blood cell and immunological response gene expression. Incyte Corporation, Incyte Corporation, August 19, 2003: US06607879 (50 worldwide citation)

The present invention relates to a composition comprising a plurality of polynucleotide probes. The composition can be used as hybridizable array elements in a microarray. The present invention also relates to a method for selecting polynucleotide probes for the composition.


10
Hafalia April J A, Ramkumar Jayalaxmi, Khare Reena, Tran Uyen K, Richardson Thomas W, Becha Shanya D, Swarnakar Anita, Chawla Narinder K, Yue Henry, Lee Ernestine A, Emerling Brooke M, Ison Craig H: Nucleic acid-associated proteins. Incyte Corporation, Hafalia April J A, Ramkumar Jayalaxmi, Khare Reena, Tran Uyen K, Richardson Thomas W, Becha Shanya D, Swarnakar Anita, Chawla Narinder K, Yue Henry, Lee Ernestine A, Emerling Brooke M, Ison Craig H, FOLEY Washington Harbour 3000 K Street NW Suite 500 Washington DC 20007 5143, October 14, 2004: WO/2004/087875 (48 worldwide citation)

Various embodiments of the invention provide human nucleic acid-associated proteins (NAAP) and polynucleotides which identify and encode NAAP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagno ...