1
David M Goldenberg: Immunotherapy of B-cell malignancies using anti-CD22 antibodies. Immunomedics, Foley & Lardner, October 23, 2001: US06306393 (244 worldwide citation)

B-cell malignancies, such as the B-cell subtype of non-Hodgkin's lymphoma and chronic lymphocytic leukemia, are significant contributors to cancer mortality. The response of B-cell malignancies to various forms of treatment is mixed. Traditional methods of treating B-cell malignancies, includin ...


2
Shui on Leung, Hans Hansen: Immunoconjugates and humanized antibodies specific for B-cell lymphoma and leukemia cells. Immunomedics, Foley & Lardner, August 4, 1998: US05789554 (189 worldwide citation)

A chimeric LL2 monoclonal antibody is described in which the complementarity determining regions (CDRs) of the light and heavy chains of the murine LL2 anti-B-lymphoma, anti-leukemia cell monoclonal antibody has been recombinantly joined to the human kappa and IgG.sub.1 constant region domains, resp ...


3
Shui on Leung, Hans Hansen: Immunoconjugates and humanized antibodies specific for B-cell lymphoma and leukemia cells. Immunomedics, Foley & Lardner, February 13, 2001: US06187287 (140 worldwide citation)

A chimeric LL2 monoclonal antibody is described in which the complementarity determining regions (CDRs) of the light and heavy chains of the murine LL2 anti-B-lymphoma, anti-leukemia cell monoclonal antibody has been recombinantly joined to the human kappa and IgG


4
David M Goldenberg: Immunotherapy of B-cell malignancies using anti-CD22 antibodies. Immunomedics, Foley & Lardner, February 6, 2001: US06183744 (137 worldwide citation)

B-Cell malignancies, such as the B-cell subtype of non-Hodgkin's lymphoma and chronic lymphocytic leukemia, are significant contributors to cancer mortality. The response of B-cell malignancies to various forms of treatment is mixed. Traditional methods of treating B-cell malignancies, includin ...


5
David M Goldenberg: Intraperative, intravascular and endoscopic tumor and lesion detection and therapy with monovalent antibody fragments. Immunomedics, Foley & Lardner, February 10, 1998: US05716595 (130 worldwide citation)

Methods are provided for close-range intraoperative, endoscopic and intravascular detection and treatment of lesions, including tumors and non-malignant lesions. The methods use agents labeled with isotopic and non-isotopic agents. Also provided are methods for detection and treatment of lesions wit ...


6
Hans J Hansen, Milton D Goldenberg: Detection and treatment of infectious and inflammatory lesions. Immunomedics, Bernhard D Saxe, May 15, 1990: US04925648 (126 worldwide citation)

A polyspecific anti-leukocyte antibody conjugate for targeting foci of leukocyte accretion comprises an immunoreactive polyspecific composite of at least two different substantially monospecific antibodies or antibody fragments, conjugated to at least one imaging agent, wherein at least two of said ...


7
Melton D Goldenberg: Lymphographic and organ imaging method and kit. Immunomedics, Bernard D Saxe, April 5, 1988: US04735210 (124 worldwide citation)

An improved method for lymphoscintigraphy or magnetic resonance lymphography involves subtraction of a negative image produced using a gross imaging agent from a positive image produced with a specific antibody imaging agent. Another embodiment of the invention uses an antibody to lymphatic tissue a ...


8
Boby M Sundoro: Bifunctional linker. Immunomedics, Bernhard D Saxe, July 14, 1987: US04680338 (124 worldwide citation)

A selective bifunctional sequential linker has the formula


9
Gary L Griffiths, Hans J Hansen: Targeted combination immunotherapy of cancer. Immunomedics, Foley & Lardner, June 20, 2000: US06077499 (120 worldwide citation)

The invention provides compositions, methods and kits for effecting therapy of a tumor in a patient. The compositions comprise (A) a first conjugate comprising a targeting moiety, a first member of a binding pair, and a first therapeutic agent, wherein the targeting moiety selectively binds to a mar ...


10
Milton David Goldenberg: Intraoperative, intravascular, and endoscopic tumor and lesion detection, biopsy and therapy. Immunomedics, Foley & Lardner, August 1, 2000: US06096289 (114 worldwide citation)

Methods are provided for close-range intraoperative, endoscopic and intravascular deflection and treatment of lesions, including tumors and non-malignant lesions. The methods use antibody fragments or subfragments labeled with isotopic and non-isotopic agents. Also provided are methods for detection ...