1
Heinz Redl, Gert Kriwetz: Apparatus for applying a tissue adhesive on the basis of human or animal proteins. Immuno Aktiengesellschaft fur chemisch medizinische Produkte, Brumbaugh Graves Donohue & Raymond, November 16, 1982: US04359049 (303 worldwide citation)

An arrangement for applying a tissue adhesive on the basis of human or animal proteins for seamlessly or seam-supportingly connecting human or animal tissue or organ parts, sealing wounds, stopping bleedings and the like, which tissue adhesive is formed in situ by bringing together solutions of the ...


2
Johann Eibl, Thomas Seelich, Heinz Redl, Georg Habison: Arrangement for applying a tissue adhesive. Immuno Aktiengesellschaft fur Chemisch Medizinische Produkte, Burns Doane Swecker & Mathis, April 5, 1988: US04735616 (258 worldwide citation)

An arrangement for applying a tissue adhesive based on human or animal proteins, to seamlessly or seam-supportingly connect human or animal tissue or organ parts by uniting with blood-clot-promoting coagulation factors (thrombin). The arrangement includes a plurality of syringe bodies commonly actua ...


3
Heinz Redl, Georg Habison: Apparatus for applying a tissue adhesive. Immuno Aktiengesellschaft fur chemisch medizinische Produkte, Burns Doane Swecker & Mathis, December 23, 1986: US04631055 (247 worldwide citation)

There is disclosed an arrangement for applying a tissue adhesive based on human or animal proteins to seamlessly or seam-supportingly connect human or animal tissue or organ parts, to seal wounds, stop bleedings and the like. The tissue adhesive is formed in situ by combining solutions of the protei ...


4
Otto Schwarz, Yendra Linnau, Franz Loblich, Thomas Seelich: Tissue adhesive. Immuno Aktiengesellschaft fur Chemisch Medizinische Produkte, Brumbaugh Graves Donohue & Raymond, March 22, 1983: US04377572 (170 worldwide citation)

This invention relates to a tissue adhesive used in mammals for among other things to connect tissue or organs, in sealing wounds, stopping bleeding and healing wounds. The adhesive comprises specified amounts of factor XIII, fibrinogen, cold-insoluble globulin and albumin and plasminogen-activator ...


5
Otto Schwarz, Yendra Linnau, Franz Loblich, Thomas Seelich: Tissue adhesive. Immuno Aktiengesellschaft fur chemisch medizinische Produkte, Brumbaugh Graves Donohue & Raymond, December 7, 1982: US04362567 (156 worldwide citation)

A tissue adhesive on the basis of human or animal protein contains factor XIII and at least 33% by weight of fibrinogen, has a ratio of factor XIII to fibrinogen, expressed in units of factor XIII per gram of fibrinogen, of at least 80, contains fibrinogen and albumin in the total protein at a ratio ...


6
Otto Schwarz, Yendra Linnau, Franz Loblich, Thomas Seelich: Tissue adhesive. Immuno Aktiengesellschaft fur chemisch medizinische Produkte, Brumbaugh Graves Donohue & Raymond, November 3, 1981: US04298598 (138 worldwide citation)

A tissue adhesive on the basis of human or animal proteins has a content of factor XIII and fibrinogen, the ratio of factor XIII to fibrinogen, expressed in units of factor XIII per gram of fibrinogen, amounting to at least 80. Furthermore, it contains a plasminogen-activator-inhibitor or plasmin-in ...


7
Thomas Seelich: Tissue adhesive. Immuno Aktiengesellschaft fur chemisch medizinische Produkte, Burns Doane Swecker & Mathis, March 20, 1990: US04909251 (112 worldwide citation)

A tissue adhesive in lyophilized form contains at least one biologically compatible tenside beside fibrinogen and factor XIII and optionally further proteins as well as adjuvants or additives. The presence of these biologically compatible tensides was found to shorten the reconstitution times of lyo ...


8
Kurt Zatloukal, Hans P Dinges: Biopsy device. Immuno Aktiengesellschaft fur chemisch medizinische Produkte, Burns Doane Swecker & Mathis, July 25, 1989: US04850373 (88 worldwide citation)

A biopsy device including a two- or multi-lumen biopsy cannula has a biopsy channel of constant cross section over its entire length and at least one application channel. On its proximal end, it is provided with connection facilities for an aspiration device and at least one application device. In o ...


9
Adolf Lindner, Yendra Linnau: Method of producing a tissue adhesive. Immuno Aktiengesellschaft fur Chemisch Medizinische Produkte, Burns Doane Swecker & Mathis, July 15, 1986: US04600574 (82 worldwide citation)

In a method of producing a tissue adhesive based on polysaccharide or on human or animal proteins, a tissue-compatible flat material is impregnated with a solution of fibrinogen and Factor XIII, and lyophilized.


10
Johann Eibl, Otto Schwarz, Fritz Elsinger, Gunter Wober, Anton Philapitsch, Yendra Linnau, Friedrich Dorner, Karl Trambauer, Wolfgang Frechinger: Method of inactivating reproducible filterable pathogens in blood products as well as a method of producing blood products. Immuno Aktiengesellschaft fur Chemisch Medizinische Produkte, Burns Doane Swecker & Mathis, February 3, 1987: US04640834 (77 worldwide citation)

A method of inactivating viruses in blood products is described, wherein the blood products are heat-treated in a humid or in a solid state in the presence of inorganic or organic hydroxyl group-containing compounds having an H.sup.+ -dissociation constant of <10.sup.-11 in a concentration of more t ...