1
Paul A Liberti, Yuzhou Wang, Weixin Tang, Brian P Feeley, Dhanesh I Gohel: Apparatus and methods for magnetic separation featuring external magnetic means. Immunivest Corporation, Dann Dorfman Herrell and Skillman, November 14, 1995: US05466574 (206 worldwide citation)

A magnetic separator for isolating magnetically-labeled substances of interest, such as immunological agents, from a non-magnetic test medium using a method of high gradient magnetic separation. The target substance is contacted with microscopic magnetic particles having a receptor for binding with ...


2
Leon W M M Terstappen, Galla Chandra Rao, Jonathan W Uhr, Emilian V Racila, Paul A Liberti: Methods and reagents for the rapid and efficient isolation of circulating cancer cells. Immunivest Corporation, Board of Regents The University of Texas System, Dann Dorfman Herrell and Skillman, April 2, 2002: US06365362 (162 worldwide citation)

A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater s ...


3
Yuzhou Wang, Weixin Tang, William J Cronin, Paul A Liberti: Method for magnetic separation featuring magnetic particles in a multi-phase system. Immunivest Corporation, Dann Dorfman Herrell and Skillman, July 30, 1996: US05541072 (146 worldwide citation)

Methods and devices are provided for separation of magnetic particles and/or magnetic-associated substances from non-magnetic associated substances and media. The methods are specifically applicable to biological separation, and utilize a phase phenomenon arising from mutual interactions between sus ...


4
Paul A Liberti, Galla C Rao, Joseph N Chiarappa: Methods for the manufacture of magnetically responsive particles. Immunivest Corporation, Dann Dorfman Herrell and Skillman, December 16, 1997: US05698271 (127 worldwide citation)

The invention relates to an improved method for the manufacture of magnetically responsive particles, also called ferrofluids. The improved method involves a heat treatment step, which may occur at various times during the preparation of the materials, including during subdivision of the magnetic st ...


5
Leon W M M Terstappen, Galla C Rao, Dhanesh I Gohel, Brian P Feeley, Steven Gross, Ellen S Church, Paul A Liberti: Affinity-binding separation and release of one or more selected subset of biological entities from a mixed population thereof. Immunivest Corporation, Dann Dorfman Herrell and Skillman, July 8, 1997: US05646001 (124 worldwide citation)

A method for separation of a mixture of biological entities into at least three distinct, subpopulations. Different antibodies are provided, with each antibody bound to a solid support in a unique manner such that by a manipulation of the physical or chemical environment, the bonds between the antib ...


6
Leon W M M Terstappen, Galla Chandra Rao, Jonathan W Uhr, Emilian V Racila, Paul A Liberti: Methods and reagents for the rapid and efficient isolation of circulating cancer cells. Immunivest Corporation, Dann Dorfman Herrell and Skillman, November 11, 2003: US06645731 (106 worldwide citation)

A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater s ...


7
Paul A Liberti, Maria A Pino: Resuspendable coated magnetic particles and stable magnetic particle suspensions. Immunivest Corporation, Dann Dorfman Herrell and Skillman, January 28, 1997: US05597531 (103 worldwide citation)

Stable suspensions of coated magnetic particles, preferably resuspendable bioactive particles particularly useful in Magnetic Resonance Imaging, are produced by disrupting, what are presumed to be, crystalline agglomerates of a parent particulate magnetic starting material in the presence of a coati ...


8
Leon W M M Terstappen, Paul A Liberti: Methods for biological substance analysis employing internal magnetic gradients separation and an externally-applied transport force. Immunivest Corporation, Dann Dorfman Herrell and Skillman, January 11, 2000: US06013188 (99 worldwide citation)

A method of qualitative analysis of microscopic biological specimens is disclosed in which the specimens are rendered magnetically responsive by immunosspecific binding with feuromagnetic colloid. The specimens are placed in a vessel having a feuromagnetic capture structure supported on a transparen ...


9
Gerald J Dolan, Leon W M M Terstappen: Magnetic separation apparatus and methods employing an internal magnetic capture gradient and an external transport force. Immunivest Corporation, Dann Dorfman Herrell and Skillman, November 16, 1999: US05985153 (79 worldwide citation)

The present invention relates to apparatus and methods for separating, immobilizing, and quantifying biological substances from within a fluid medium. Biological substances are observed by employing a high internal gradient magnetic capture structure formed within a vessel, in conjunction with an ex ...


10
Leon W M M Terstappen, Paul A Liberti: Quantitative cell analysis methods employing magnetic separation. Immunivest Corporation, Dann Dorfman Herrell and Skillman, November 30, 1999: US05993665 (76 worldwide citation)

A method of quantitative analysis of microscopic biological specimens in a fluid medium is disclosed in which the specimens are rendered magnetically responsive by immunospecific binding with ferromagnetic colloid. A known quantity of magnetically-responsive marker particles are added to the fluid m ...