1
Paul E Baker: Serum-free cell culture medium and process for making same. Immunex Corporation, Christensen O Connor Johnson & Kindness, December 24, 1985: US04560655 (198 worldwide citation)

A defined serum-free medium that is capable of growing a wide range of suspension and monolayer cells includes a serum substitute composed of fetuin, transferrin, phosphatidylcholine, e.g., 1-oleoyl-2-palmitoyl-phosphatidylcholine, linoleic acid and cholesterol. The medium also includes various inor ...


2
Benson M Curtis, Linda S Park, David J Cosman: Fusion proteins comprising GM-CSF and IL-3. Immunex Corporation, Christopher L Wight, December 17, 1991: US05073627 (189 worldwide citation)

A fusion protein is disclosed which comprises GM-CSF and IL-3. Such fusion proteins more biologically active than GM-CSF or IL-3 alone or GM-CSF and IL-3 combined.


3
Cindy A Jacobs, Craig A Smith: Methods of lowering active TNF-.alpha. levels in mammals using tumor necrosis factor receptor. Immunex Corporation, Stephen L Malaska, February 25, 1997: US05605690 (171 worldwide citation)

A method for treating TNF-dependent inflammatory diseases in a mammal by administering a TNF antagonist, such as soluble TNFR.


4
Steven Gillis: Method for improving autologous transplantation. Immunex Corporation, Christopher L Wight, April 6, 1993: US05199942 (151 worldwide citation)

There is disclosed a method for autologous hematopoietic cell transplantation of patients receiving cytoreductive therapy, comprising: (1) obtaining hematopoietic progenitor cells from bone marrow or peripheral blood from a patient prior to cytoreductive therapy; (2) expanding the hematopoietic prog ...


5
Thomas P Hopp, Kathryn S Prickett: Hybridoma and monoclonal antibody for use in an immunoaffinity purification system. Immunex Corporation, Scott G Hallquist, Christopher L Wight, April 30, 1991: US05011912 (144 worldwide citation)

A particular calcium-dependent monoclonal antibody, 4E11, is produced from a murine hybridoma cell line and is useful for purifying a recombinant fusion protein having an N-terminal identification peptide DYKDDDDK to which the monoclonal antibody binds.


6
Jacques H Bertoglio Matte: Immediate ligand detection assay. Immunex Corporation, Christensen O Connor Johnson & Kindness, February 4, 1986: US04568649 (125 worldwide citation)

A test kit and assay for detecting the presence of minute amounts of an organic reactant in a test sample includes a plurality of beads or other types of support structures that are impregnated with a fluorescer and coated with a ligand that specifically binds to the organic reactant being investiga ...


7
Raymond G Goodwin, Craig A Smith, Richard J Armitage, Hans Juergen Gruss: CD30 ligand. Immunex Corporation, Kathryn A Anderson, January 2, 1996: US05480981 (114 worldwide citation)

There is disclosed a polypeptide (CD30-L) and DNA sequences, vectors and transformed host cells useful in providing CD30-L polypeptides. The CD30-L polypeptide binds to the receptor known as CD30, which is expressed on a number of cell types, among which are Hodgkin's Disease tumor cells, large cell ...


8
Michael C Deeley, Steven D Gimpel, Virginia L Price: Analogs of human granulocyte-macrophage colony stimulating factor. Immunex Corporation, Foley & Lardner, July 20, 1993: US05229496 (100 worldwide citation)

Amplified expression of recombinant DNA products is achieved in hosts expressing protease that cleave at multi-basic amino acid residues. To this end, wild-type genes encoding the desired protein products are mutated by substituting codons or eliminating codons encoding multi-basic amino acid residu ...


9
Michael C Deeley, Virginia L Price: DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues. Immunex Corporation, Foley & Lardner, February 21, 1995: US05391485 (95 worldwide citation)

Amplified expression of recombinant DNA products is achieved in hosts expressing proteases that cleave at multi-basic amino acid residues. To this end, cDNAs encoding granulocyte-macrophage colony stimulating factor (GM-CSF) are mutated such that one or both of the arginine residues at positions 23 ...


10
Michael C Deeley, Virginia L Price: Analogs of human granulocyte-macrophage colony stimulating factor. Immunex Corporation, Foley & Lardner, February 28, 1995: US05393870 (95 worldwide citation)

Amplified expression of recombinant DNA products is achieved in hosts expressing proteases that cleave at multi-basic amino acid residues. To this end, cDNAs encoding granulocyte-macrophage colony stimulating factor (GM-CSF) are mutated such that one or both of the arginine residues at positions 23 ...