1
Evan C Unger, David W Yellowhair: Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously. ImaRx Pharmaceutical, Woodcock Washburn Kurtz Mackiewicz & Norris, September 24, 1996: US05558092 (406 worldwide citation)

Methods and apparatus for performing diagnostic ultrasound simultaneously with the application of therapeutic ultrasonic waves are disclosed. The methods and apparatus are particularly advantageous in performing ultrasonic imaging of a region of a patient while simultaneously applying therapeutic ul ...


2
Evan C Unger, Thomas A Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu: Therapeutic drug delivery systems. ImaRx Pharmaceutical, Woodcock Washburn Kurtz Mackiewicz & Norris, December 3, 1996: US05580575 (298 worldwide citation)

Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug a ...


3
Evan C Unger, Terry O Matsunaga, David Yellowhair: Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles. ImaRx Pharmaceutical, Woodcock Washburn Kurtz Mackiewicz & Norris, March 31, 1998: US05733572 (255 worldwide citation)

Gas and gaseous precursor filled microspheres, and foams thereof, provide novel topical and subcutaneous delivery vehicles for various active ingredients, including drugs and cosmetics.


4
Evan C Unger, Thomas A Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu: Method of preparing gas and gaseous precursor-filled microspheres. ImaRx Pharmaceutical, Woodcock Washburn Kurtz Mackiewicz & Norris, December 17, 1996: US05585112 (215 worldwide citation)

Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.


5
Evan C Unger, Thomas A Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu: Therapeutic drug delivery systems. ImaRx Pharmaceutical, Woodcock Washburn Kurtz Mackiewicz & Norris, June 23, 1998: US05770222 (211 worldwide citation)

Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug a ...


6
Evan C Unger: Charged lipids and uses for the same. ImaRx Pharmaceutical, Woodcock Washburn Kurtz Mackiewicz & Norris, September 19, 2000: US06120751 (173 worldwide citation)

The present invention is directed to charged lipids, compositions comprising charged lipids, and the use of these compositions in drug delivery, targeted drug delivery, therapeutic imaging and diagnostic imaging, as well as their use as contrast agents.


7
Evan C Unger, Thomas A Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu: Targeted gas and gaseous precursor-filled liposomes. ImaRx Pharmaceutical, Woodcock Washburn Kurtz Mackiewicz & Norris, June 6, 2000: US06071495 (160 worldwide citation)

Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.


8
Evan C Unger: Low density microspheres and their use as contrast agents for computed tomography, and in other applications. Imarx Pharmaceutical, Woodcock Washburn Kurtz Mackiewicz & Norris, August 20, 1996: US05547656 (128 worldwide citation)

Substantially homogeneous aqueous suspensions of low density microspheres are presented as contrast media for imaging the gastrointestinal tract and other body cavities using computed tomography. In one embodiment, the low density microspheres are gas-filled. With computed tomography, the contrast m ...


9
Evan C Unger: Prodrugs comprising fluorinated amphiphiles. Imarx Pharmaceutical, Woodcock Washburn Kurtz Mackiewicz & Norris, February 22, 2000: US06028066 (125 worldwide citation)

The present invention describes, inter alia, novel prodrugs comprising fluorinated amphiphiles, compositions comprising the novel prodrugs, and methods of use of the prodrugs and compositions.


10
Evan C Unger: Methods for diagnostic imaging using a renal contrast agent and a vasodilator. ImaRx Pharmaceutical, Woodcock Washburn Kurtz Mackiewicz & Norris, December 8, 1998: US05846517 (116 worldwide citation)

A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator ...