1
Belleau Bernard, Belleau Pierette, Nguyen Ba Nghe: Substituted -1,3-oxathiolanes with antiviral properties.. Iaf Biochem Int, August 16, 1990: EP0382526-A2 (123 worldwide citation)

Disclosed are compounds of the formula wherein R1 is hydrogen; R2 is a purine or pyrimidine base or an analogue or derivative thereof; Z is S, S=O or SO2; and pharmaceutically acceptable derivatives thereof. Also described are use of the compounds as antiviral agents, pharmaceutical formulations, an ...


2
Belleau Bernard, Dixit Dilop, Nguyen Ba Nghe: 2-substituted-4-substituted-1,3-dioxolanes, synthesis and use thereof.. Iaf Biochem Int, October 18, 1989: EP0337713-A2 (103 worldwide citation)

There is provided novel 2-substituted-4-substituted-1,3-dioxolanes which are particularly useful as antiviral agents.


3
Mansour Tarek, Hin Haolun, Tse Allan H L, Siddiqui Arshad M: Processes for the diastereo-selective synthesis of nucleosides.. Iaf Biochem Int, November 25, 1992: EP0515156-A1 (88 worldwide citation)

The present invention relates to highly diastereoselective processes for production of cis-nucleotides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.


4
Belleau Bernard, Nguyen Ba Nghe: Use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis b.. Iaf Biochem Int, July 8, 1992: EP0494119-A1 (87 worldwide citation)

Use of a compound of formula (I) or a pharmaceutically acceptable derivative thereof in the manufacture of a medicament for the treatment of hepatitis B is disclosed.


5
Belleau Bernard, Nguyen Ba Nghe: 1,3-oxathiolanes useful in the treatment of hepatitis.. Iaf Biochem Int, November 25, 1992: EP0515144-A1 (67 worldwide citation)

The present invention relates to the use of nucleoside analogues in the treatment of viral infections. More specifically it is concerned with the use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis, in particular hepatitis B.


6
Mansour Tarek, Jin Haolun, Tse Allan H L, Siddiqui Arshad M: Processes for the diastereoselective synthesis of nucleosides.. Iaf Biochem Int, November 25, 1992: EP0515157-A1 (59 worldwide citation)

The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.


7
Dionne Gervais: 1,3-oxathiolane nucleoside analogues.. Iaf Biochem Int, February 3, 1993: EP0526253-A1 (52 worldwide citation)

The invention relates to 1,3-oxathiolane nucleoside analogues and their use in the treatment of viral infections. More specifically, this invention relates to (-)-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyri midin-2-one and pharmaceuticall acceptable derivatives and pharmaceuti ...


8
Schiller Peter W: Dermorphin analogs, their methods of preparation, pharmaceutical compositions, and methods of therapeutic treatment using the same.. Iaf Biochem Int, January 10, 1990: EP0350221-A2 (12 worldwide citation)

Peptides are provided which are suitable for the treatment of pain and gastro-intestinal disorders, such as diarrhea, and are represented by the structure: where values for the substituents and n are disclosed herein. Methods for preparing these peptides by solution and solid phase syntheses are als ...


9
Belleau Bernard, Nguyen Ba Nghe, Belleau Pierette: Substituted-1,3-oxathiolanes with antiviral properties. Iaf Biochem Int, May 15, 1996: EP0711771-A2 (11 worldwide citation)

Disclosed are compounds of the formula wherein R1 is hydrogen; R2 is a purine or pyrimidine base or an analogue or derivative thereof; Z is S, S=O or SO2; and pharmaceutically acceptable derivatives thereof. Also described are use of the compounds as antiviral agents, pharmaceutical formulations, an ...


10
Bellini Francesco, Dionne Gervais, Lacroix Martial: Synthetic peptides and mixtures thereof for detecting hiv antibodies.. Iaf Biochem Int, August 2, 1989: EP0326490-A2 (9 worldwide citation)

There is provided cyclic peptides of the general formula wherein x represents the amino terminus, one amino acid or amino acid sequence starting with amino acid 604 and going back as far as amino acid 586 (gp41-HIV-1); and y represents the carboxy terminus, an amino acid or amino acid sequence start ...