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Hu Zhihao, Valle Fernando: Enhanced production of fatty acid derivatives. Ls9, Hu Zhihao, Valle Fernando, SONG Victor L, October 2, 2008: WO/2008/119082 (71 worldwide citation)

Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use. The products are particularly useful as biofuels.


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GREENFIELD Derek L, HOM Louis G, SANCHEZ RIERA Fernando A, HU Zhihao, ARLAGADDA Vikranth, GROBAN Eli S, FRYKMAN Scott A: PROCÉDÉS ET COMPOSITIONS POUR UNE PRODUCTION AMÉLIORÉE DES ACIDES GRAS ET LEURS DÉRIVÉS, METHODS AND COMPOSITIONS FOR IMPROVED PRODUCTION OF FATTY ACIDS AND DERIVATIVES THEREOF. LS9, GREENFIELD Derek L, HOM Louis G, SANCHEZ RIERA Fernando A, HU Zhihao, ARLAGADDA Vikranth, GROBAN Eli S, FRYKMAN Scott A, JUDGE Linda R, November 15, 2012: WO/2012/154329 (2 worldwide citation)

The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and ...


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Hutchinson C Richard, Reid Ralph C, Hu Zhihao, Rascher Andreas, Schirmer Andreas, Mcdaniel Robert: Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthases and accessory proteins, and uses thereof. Kosan Biosciences, Hutchinson C Richard, Reid Ralph C, Hu Zhihao, Rascher Andreas, Schirmer Andreas, Mcdaniel Robert, APPLE Randolph T, December 24, 2003: WO/2003/106653 (1 worldwide citation)

Abstract The invention relates to recombinant polyketide synthase enzymes, polyketide modifying proteins, and other proteins involved in polyketide biosynthesis or function. The invention provides domains of geldanamycin and herbimycin polyketide synthases, polynucleotides that encode such enzymes, ...


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HU Zhihao, LEE Grace J, SCHIRMER Andreas, ZAKHARYEVICH Kseniya, GREENFIELD Derek L, BARON Tarah S, HOLDEN Kevin: PRODUCTION DACIDES GRAS À CHAÎNE RAMIFIÉE ET DE LEURS DÉRIVÉS DANS DES CELLULES MICROBIENNES RECOMBINANTES, PRODUCTION OF BRANCHED CHAIN FATTY ACIDS AND DERIVATIVES THEREOF IN RECOMBINANT MICROBIAL CELLS. LS9, HU Zhihao, LEE Grace J, SCHIRMER Andreas, ZAKHARYEVICH Kseniya, GREENFIELD Derek L, BARON Tarah S, HOLDEN Kevin, KILYK JR John, July 19, 2012: WO/2012/096686 (1 worldwide citation)

Recombinant microbial cells are provided which have been engineered to produce branched chain products such as branched fatty acid derivatives by the fatty acid biosynthetic pathway, and methods of making branched fatty acid derivatives using the recombinant microbial cells.


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Reid Ralph C, Hu Zhihao, Tang Li: Gene cluster for fostriecin biosynthesis. Kosan Biosciences, Reid Ralph C, Hu Zhihao, Tang Li, APPLE Randolph Ted, March 3, 2005: WO/2005/019426

Domains of fostriecin polyketide synthase and modification enzymes and polynucleotides encoding them are provided. Methods to prepare fostriecin in pharmaceutically useful quantities are described, as are methods to prepare fostriecin analogs and other polyketides using the polynucleotides encoding ...


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Hu Zhihao, Hutchinson Richard C: Methods and cells for improved production of polyketides. Kosan Biosciences, Hu Zhihao, Hutchinson Richard C, APPLE Randolph Ted, December 24, 2003: WO/2003/106638

Described are host cells that contain a polyketide synthase gene and a thioesterase II gene, where the polyketide synthase gene has been modified to prevent utilization of its native starter unit for its expressed polyketide synthase. Also described are host cells containing a polyketide synthase ge ...


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Katz Leonard, Reid Ralph C, Hu Zhihao, Schirmer Andreas, Ward Shannon L, Reeves Christopher: Recombinant chalcomycin polyketide synthase and modifying genes. Kosan Biosciences, Katz Leonard, Reid Ralph C, Hu Zhihao, Schirmer Andreas, Ward Shannon L, Reeves Christopher, APPLE Randolph Ted, March 4, 2004: WO/2004/018703

Domains of chalcomycin polyketide synthases and modification enzymes and polynucleotides encoding them are provided. Methods to prepare chalcomycin in pharmaceutically useful quantities axe described, as are methods to prepare chalcomycin analogs and other polyketides using the polynucleotides encod ...


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Hutchinson Richard C, Katz Leonard, Reid Ralph, Hu Zhihao, Gramajo Hugo: Recombinant genes for polyketide modifying enzymes. Kosan Biosciences, Hutchinson Richard C, Katz Leonard, Reid Ralph, Hu Zhihao, Gramajo Hugo, APPLE Ted, January 8, 2004: WO/2004/003169

Materials and methods to produce modified polyketides are disclosed. The biosynthesis, transfer and regulator genes for various sugars to effectuate polyketide modification are disclosed.



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